Modeling sarcoplasmic reticulum Ca in rat cardiomyocytes.

The sarcoplasmic reticulum (SR) primarily serves as the intracellular Ca store in cardiac myocytes, mediating cellular function under cardiac physiology and diseases. However, the properties of cardiac SR Ca have not yet been fully determined, particularly in rats and mice, which are the most commonly used experimental species in studies on cardiac physiology and diseases. Here, we developed a spatially detailed numerical model to deduce Ca movements inside the junctional SR (jSR) cisternae of rat cardiomyocytes.