A novel peptide-based tau aggregation inhibitor as a potential therapeutic for Alzheimer's disease and other tauopathies.

Introduction: As aggregation underpins Tau toxicity, aggregation inhibitor peptides may have disease-modifying potential. They are therefore currently being designed and target either the VQIVYK aggregation-promoting hotspot found in all Tau isoforms or the VQIINK aggregation-promoting hotspot found in 4R isoforms. However, for any Tau aggregation inhibitor to potentially be clinically relevant for other tauopathies, it should target both hotspots to suppress aggregation of Tau isoforms, be stable, cross the blood-brain barrier, and rescue aggregation-dependent Tau phenotypes in vivo.

Hierarchical multi-task deep learning-assisted construction of human gut microbiota reactive oxygen species-scavenging enzymes database.

In the process of oxygen reduction, reactive oxygen species (ROS) are generated as intermediates, including superoxide anion (O), hydrogen peroxide (HO), and hydroxyl radicals (OH). ROS can be destructive, and an imbalance between oxidants and antioxidants in the body can lead to pathological inflammation. Inappropriate ROS production can cause oxidative damage, disrupting the balance in the body and potentially leading to DNA damage in intestinal epithelial cells and beneficial bacteria.

Corrigendum to "Giant squamous cell carcinoma of penis with rapid progression" [Urol. Case Rep. 34 (2021) 101496].

[This corrects the article DOI: 10.1016/j.eucr.

Corrigendum to "Basal cell carcinoma arising from the scrotum: An understated entity" [Urol Case Rep 33 (2020) 101332].

[This corrects the article DOI: 10.1016/j.eucr.

Correction to "Dynamic Control of Self-Assembly of Amphiphilic Conjugated Alkenes in Water by Reactions".

[This corrects the article DOI: 10.1021/acsomega.1c07026.

Dynamic Control of Self-Assembly of Amphiphilic Conjugated Alkenes in Water by Reactions.

Nature sets a great example of how to precisely control self-assembly to obtain distinct structures upon external stimuli and perform specific functions to sustain important biological tasks. In the present study, we report the design and control of self-assembly of an amphiphilic conjugated alkene in water. The morphologies of the self-assembled structures are highly dependent on the anions.

Comprehensive Analysis and Identification of an Immune-Related Gene Signature with Prognostic Value for Prostate Cancer.

Background: The tumor microenvironment (TME) has recently been proven to play a crucial role in the development and prognosis of tumors. However, the current knowledge on the potential of the TME in prostate cancer (PCa) remains scarce.

Purpose: This study aims to elucidate the value of TME-related genes for PCa prognosis by integrative bioinformatics analysis.

Tunica vaginalis testis metastasis as the first clinical manifestation of pancreatic adenocarcinoma: A case report.

Background: Metastases from pancreas or ampullary malignancies are common, but the spread to testicle and paratesticular tissue is exceedingly rare. To the best of our knowledge, fewer than 30 cases have been reported in the literature. More rarely, metastasis to tunica vaginalis testis occurs without involvement of the testes and epididymis.

Giant squamous cell carcinoma of penis with rapid progression.

A 65-year-old man presented with a giant ulcerative and malodorous genital mass rapidly growing for 5 months. On first presentation, he noticed a 3 cm × 2 cm cauliflower-like mass located in the penile dorsal shaft. But, he rejected any operation.

Basal cell carcinoma arising from the scrotum: An understated entity.

Basal cell carcinoma (BCC) is the most commonly occurring carcinoma among humans. Reports of this lesion on nonexposed areas, such as the scrotum, soles, vulva, groin, pubic region, and axilla, are relatively uncommon. We present the case of a male patient with BCC located in the scrotum with a duration of 12 years who was successfully treated by local excision.

The clinicopathological and prognostic value of CD44 expression in bladder cancer: a study based on meta-analysis and TCGA data.

CD44 is reported to be involved in tumor invasion and metastasis. However, the role of cancer stem cell marker CD44 in bladder cancer still remains controversial. Hence, the correlations between CD44 expression and the clinicopathological features and the prognosis of bladder cancer were investigated.

LncRNA Promotes Bladder Cancer Occurrence Via Protecting from Downregulation by Sponging .

As a subtype of human genitourinary system cancer, the morbidity of bladder cancer (BC) continues to rise. Because of the high potentiality of cell metastasis, the 5-year survival rate of BC is relatively low. Long noncoding RNAs (lncRNAs) have been verified by a large body of literature to engage in the tumorigenesis of a few cancers.

Noise-suppressing channel allocation in dynamic DWDM-QKD networks using LightGBM.

Integrating quantum key distribution (QKD) with existing optical networks is highly desired to reduce the deployment costs and achieve efficient resource utilization, and some point-to-point transmitting experiments have verified its feasibility. Nevertheless, there are still many problems in the realistic scenario where QKD coexists with dynamic data traffics. On the one hand, the conventional static channel allocation schemes cannot guarantee the quality of quantum channels in the presence of the time-varying noises.

A meta-analysis and The Cancer Genome Atlas data of prostate cancer risk and prognosis using epithelial cell adhesion molecule (EpCAM) expression.

Background: Epithelial cell adhesion molecule (EpCAM) expression has been reported in many types of cancer, including prostate cancer (PCa). However, the role of EpCAM expression remains inconsistent. We conducted a meta-analysis to assess the clinicopathological and prognostic significance of EpCAM expression in PCa.

Experimental wavelength-space division multiplexing of quantum key distribution with classical optical communication over multicore fiber.

We demonstrate quantum key distribution (QKD) with classical signals in a seven-core fiber using dense wavelength division multiplexing. Quantum signals are transmitted in an outer core separately and intercore crosstalk (IC-XT) is the main impairment of them. In order to alleviate IC-XT, we propose a quantum-classical interleave scheme.

Lower pole approach in retroperitoneal laparoscopic radical nephrectomy: a new approach for the management of renal vascular pedicle.

Background: The objective of this study was to examine the effectiveness and safety of lower pole (LP) approach in retroperitoneal laparoscopic radical nephrectomy (LRN).

Methods: One hundred thirty-two renal cancer patients were scheduled for selective retroperitoneal LRN. The surgery parameters and outcomes were compared.

The High Prevalence of Low HDL-Cholesterol Levels and Dyslipidemia in Rural Populations in Northwestern China.

Background: Dyslipidemia is a major health problem in China and an important modifiable cardiovascular disease (CVD) risk factor. This study aimed to describe the prevalence of dyslipidemia and low high density lipoprotein cholesterol (HDL-cholesterol) and associated risk factors among adults in rural northwest China.

Methods: In a cross-sectional analyses involving 2,980 adults aged >18 years, information on the demographics, cigarette smoking, alcohol consumption, education, and medical history was collected via face-to-face interviews.

Outdoor temperature, blood pressure, and cardiovascular disease mortality among 23 000 individuals with diagnosed cardiovascular diseases from China.

Introduction: Blood pressure is a major cause of cardiovascular disease (CVD) and both may increase as outdoor temperatures fall. However, there are still limited data about seasonal variation in blood pressure and CVD mortality among patients with prior-CVD.

Methods: We analysed data on 23 000 individuals with prior-CVD who were recruited from 10 diverse regions into the China Kadoorie Biobank during 2004-8.

[Effects of different feeding practices at 0-6 months and living economic conditions on anemia prevalence of infants and young children].

Objective: In order to understand the anemic prevalence in the infants and young children and its relation to the feeding pattern at 0-6 months and on economic income.

Methods: A questionnaire survey were used to collect the information on nutritional and health status of infants and young children (6 to 23 months) living in poverty-rural areas of Gansu Province, and hemoglobin concentration was measured.

Results: The prevalence of anemia was 58.

[The tendency of prevalence of hypertension in two countries in Gansu province from 1990 to 2012].

Objective: To study the variation tendency of hypertension in two rural areas in Gansu, and provide epidemiological evidence to evaluate the hypertension of rural residents.

Methods: Using equidistant random sampling method and cross-sectional sentinel monitoring, two remote natural villages, Yangzhuang and Xiangming, at Yellow river and Yangtze river valley were selected as hypertension monitoring site. From 1990 to 2012, clinical examination to the resident above 18 years old was carried out continuously for 23 years, 11 164 cases were included.