Changing Patterns in Clinicopathological Characteristics of Breast Cancer and Prevalence of Mutations: Analysis in a Rural Area of Southern China.

Purpose: Although the burden of breast cancer remains especially high in rural China, data on the clinicopathological characteristics and prevalence of the breast cancer susceptibility gene 1/2 () mutations in patients with breast cancer remain limited. We investigated the clinicopathological characteristics, changing patterns, and prevalence of mutations in patients with breast cancer.

Patients And Methods: The clinicopathological characteristics of 3712 women with pathologically confirmed primary breast cancer treated at Meizhou People's Hospital between January 2005 and December 2018 were evaluated.

Diagnostic values of MMP-7, MMP-9, MMP-11, TIMP-1, TIMP-2, CEA, and CA19-9 in patients with colorectal cancer.

Objective: Colorectal cancer (CRC) is one of the most common and lethal malignancies. The identification of precise and noninvasive biomarkers is urgently needed to aid the early diagnosis and clinical management of CRC.

Methods: A total of 112 patients with CRC and 115 healthy control subjects were included in this study.

Detection of critical genes associated with poor prognosis in breast cancer via integrated bioinformatics analyses.

Purpose: To explore the potential prognostic differentially expressed genes (DEGs) in breast cancer (BC) via bioinformatic analysis and elucidate possible mechanisms underlying the effects on BC progression.

Methods: Three datasets (GSE21422, GSE31192 and GSE42568) were extracted from Gene Expression Omnibus (GEO) information bank. The GEO2R tool and Venn diagram softwares were used for data filtration, GO (Gene Ontology) and KEGG (Kyoto Encyclopedia of Genes and Genomes) analysis method were used to functionally annotate the selected DEGs.