HPV16 infection promotes the malignant transformation of the esophagus and progression of esophageal squamous cell carcinoma.

Esophageal squamous cell carcinoma (ESCC) may be correlated with HPV infection, and the mechanism underlying the ESCC formation induced by HPV16 infection remains elusive. Here, we overexpressed HPV16 E6 and E7 and coordinated the overexpression of these two genes in EPC2 and ESCC cells. We found that E7 and coordinated expression of E6 and E7 promoted the proliferation of EPC2 cells, and upregulation of shh was responsible for cell proliferation since the use of vismodegib led to the failure of organoid formation.

Extensively infarcted giant solitary hamartomatous polyp treated with endoscopic full-thickness resection: A case report.

Background: Solitary hamartomatous polyps (SHPs) are rare lesions. Endoscopic full-thickness resection (EFTR) is a highly efficient and minimally invasive endoscopic procedure that benefits from complete lesion removal and high safety.

Case Summary: A 47-year-old man was admitted to our hospital after experiencing hypogastric pain and constipation for over fifteen days.

Functional Bimetal/Carbon Composites Co/Zr@AC for Pesticide Atrazine Removal from Water.

Atrazine is a toxic and refractory herbicide that poses threats to human health and the ecological environment. In order to efficiently remove atrazine from water, a novel material, Co/Zr@AC, was developed. This novel material is prepared by loading two metal elements, cobalt and zirconium, onto activated carbon (AC) through solution impregnation and high-temperature calcination.

Association of Gut Microbiota With Intestinal Ischemia/Reperfusion Injury.

Intestinal ischemia/reperfusion (II/R) is a common acute and critical condition in clinical practice with a high mortality rate. However, there is still a lack of effective prevention and treatment measures for II/R injury. The role of the gut microbiota in II/R has attracted widespread attention.

Propionate alleviates myocardial ischemia-reperfusion injury aggravated by Angiotensin II dependent on caveolin-1/ACE2 axis through GPR41.

Myocardial ischemia/reperfusion (I/R) injury is still a lack of effective therapeutic drugs, and its molecular mechanism is urgently needed. Studies have shown that the intestinal flora plays an important regulatory role in cardiovascular injury, but the specific mechanism has not been fully elucidated. In this study, we found that an increase in Ang II in plasma was accompanied by an increase in the levels of myocardial injury during myocardial reperfusion in patients with cardiopulmonary bypass.

StructADMM: Achieving Ultrahigh Efficiency in Structured Pruning for DNNs.

Weight pruning methods of deep neural networks (DNNs) have been demonstrated to achieve a good model pruning rate without loss of accuracy, thereby alleviating the significant computation/storage requirements of large-scale DNNs. Structured weight pruning methods have been proposed to overcome the limitation of irregular network structure and demonstrated actual GPU acceleration. However, in prior work, the pruning rate (degree of sparsity) and GPU acceleration are limited (to less than 50%) when accuracy needs to be maintained.

Large depth-of-field three-dimensional shape measurement with the focal sweep technique.

Three-dimensional (3D) shape measurement based on the fringe projection technique has been extensively used for scientific discoveries and industrial practices. Yet, one of the most challenging issues is its limited depth of field (DOF). This paper presents a method to drastically increase DOF of 3D shape measurement technique by employing the focal sweep method.

A Review on Recent Treatment Technology for Herbicide Atrazine in Contaminated Environment.

Atrazine is a kind of triazine herbicide that is widely used for weed control due to its good weeding effect and low price. The study of atrazine removal from the environment is of great significance due to the stable structure, difficult degradation, long residence time in environment, and toxicity on the organism and human beings. Therefore, a number of processing technologies are developed and widely employed for atrazine degradation, such as adsorption, photochemical catalysis, biodegradation, etc.

Investigation and Modeling of Multi-Node Body Channel Wireless Power Transfer.

Insufficient power supply is a huge challenge for wireless body area network (WBAN). Body channel wireless power transfer (BC-WPT) is promising to realize multi-node high-efficiency power transmission for miniaturized WBAN nodes. However, the behavior of BC-WPT, especially in the multi-node scenario, is still lacking in research.

Big End Double-Layer Stents for the Treatment of Gastric Outlet Obstruction Caused by Stomach Cancer.

Objectives: This study is aimed at evaluating the efficacy and safety of the big end double-layer uncovered self-expanding metal stents (SEMS) for the treatment of gastric outlet obstruction (GOO) caused by distal stomach cancer.

Methods: Seventy three patients receiving big end double-layer uncovered SEMS for the treatment of GOO caused by distal gastric cancer will be included in this multicenter prospective clinical trial. The main outcome measures included the functional outcome, the complications, the reinterventional rates, the average treatment charges, and the mean survival time.

An Auto Loss Compensation System for Capacitive-Coupled Body Channel Communication.

This paper proposes an auto loss compensation (ALC) system to attenuate the time-variant path loss for capacitive-coupled body channel communication (CC-BCC). The system employs a time-division gradient indicator to continuously monitor the compensation conditions, and dynamically adjust the compensation inductor through a proportional integral (PI) controller. With the closed-loop topology, the proposed ALC system has two major advantages: first, the path loss induced by the backward coupling effect can be compensated without calibration; second, this system can dynamically attenuate the path loss, even when the channel characteristics vary with time.

Effects of Ca and fulvic acids on atrazine degradation by nano-TiO: Performances and mechanisms.

In this study, the adsorption and UV photocatalytic degradation of atrazine using nano-TiO particles were studied systematically, and the colloidal stability of nano-TiO particles in solution was also investigated to reveal the removal mechanism. Experiments which contained the first 6.0 hours darkness and 4.

Dynamic Channel Modeling and OFDM System Analysis for Capacitive Coupling Body Channel Communication.

Body channel communication (BCC) has the potential to achieve better energy efficiency over other conventional wireless communication schemes, thus becomes a promising solution for the wireless body area network. To deal with the fading and dynamic variation challenges of BCC, the technique of orthogonal frequency-division multiplexing (OFDM) is a promising candidate. However, some basic issues in OFDM including the pilot design and the modulating methods have not been analyzed for BCC.

Dexmedetomidine Preconditioning Protects Cardiomyocytes Against Hypoxia/Reoxygenation-Induced Necroptosis by Inhibiting HMGB1-Mediated Inflammation.

Myocardial ischemia/reperfusion (I/R) injury is a serious threat to the health of people around the world. Recent evidence has indicated that high-mobility group box-1 (HMGB1) is involved in I/R-induced inflammation, and inflammation can cause necroptosis of cells. Interestingly, dexmedetomidine (DEX) has anti-inflammatory properties.

Comparison of big funnel and individualized stents for management of stomach cancer with gastric outlet obstruction.

Background: Previous studies reported a similar rate of complications, including stent migration and obstruction, between individualized stents and the standard uncovered stents in gastric outlet obstruction (GOO) caused by distal stomach cancer. The objective of this study was to evaluate the efficacy and safety of funnel stents for management of GOO caused by distal stomach cancer.

Methods: This study was designed as a multicenter, controlled, prospective, and randomized clinical trial involving 4 hospitals.

Transfection of the CagA gene alters MUC5AC expression in human gastric cancer cells.

, the primary causative agent of stomach cancer, is known to affect gastric mucin expression. However, the underlying molecular mechanisms mediating this -dependent effect remain unknown. In the present study, the effect of exogenous expression of the virulence factor, CagA, on mucin 5AC oligomeric muscus/gel-forming (MUC5AC) expression was investigated using an model of the gastric mucosa.