Co-existence of :: fusion and variant in a pediatric case with acute myeloid leukemia: a case report and literature review.

The lysine(K)-specific methyltransferase 2A gene (), previously known as mixed lineage leukemia (), frequently rearranged in acute leukemia, belongs to one of the most promiscuous genes and has been found fused to more than 80 different partners. :: fusion is a relatively uncommon rearrangement observed in pediatric acute myeloid leukemia (AML) patients, some of which may harbor other mutations. We herein report a case of AML-M4-infant with :: fusion and variant.

MicroRNAs as Biomarkers and Therapeutic Targets for Nonalcoholic Fatty Liver Disease: A Narrative Review.

Purpose: Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in the world. However, biomarkers for NAFLD diagnosis and liver-specific drugs for treatment are lacking. This article reviews the possibility of circulating miRNAs in the diagnosis and treatment of NAFLD diseases and focuses on several well-studied miRNAs to provide preclinical data for subsequent related studies.

[Application Value of Plasma vWF and ADAMTS-13 in Evaluating Postoprative Vascular Endothelial Injury and Prognosis in Children with VSD].

Objective: To dynamically observe the levels and activities of von Willebrand factor (vWF) and ADAMTS-13 (a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13) in plasma of children with congenital ventricular septal defect (VSD) during perioperative period, and explore the value of plasma vWF antigen (vWF:Ag) and ADAMTS-13 activity (ADAMTS-13: AC) in evaluating vascular endothelial injury and prognosis in children with VSD.

Methods: In this cross-sectional study, a total of 74 children with VSD who underwent surgical treatment in TEDA International Cardiovascular Hospital from September 2018 to March 2019 were enrolled in the observation group. Among them, there were 28 cases of pure VSD, 32 cases of VSD combined with pulmonary hypertension, and 14 cases of VSD combined with valvular heart disease.

S878G, G116S, A536T, and S3708R tetramutation co-contribute to a pediatric acute myeloid leukemia: Case report and literature review.

Acute myeloid leukemia (AML) is a clinically, morphologically, and genetically heterogeneous group of malignancies characterized by a wide range of genomic alterations responsible for defective regulation of the differentiation and self-renewal programs of hematopoietic stem cells. Here, we report a 4-month-old boy who had acute onset with leukocytosis and abdominal mass. The morphological analysis of bone marrow (BM) smear revealed extremely marrow hyperplasia, large quantities of immature cells, and primary and immature monocytic hyperplasia accounting for 57.

TiCT MXene/urchin-like PANI hollow nanosphere composite for high performance flexible ammonia gas sensor.

Ammonia (NH) has been used as a typical indicator to monitor food spoilage, human health, and air quality. However, the development of flexible NH sensors with high response, excellent selectivity and low cost remains a huge challenge. Herein, a high performance NH sensor based on TiCT MXene nanosheet/urchin-like PANI hollow nanosphere composite (MP) was fabricated through template method and in situ polymerization.

High discharge intensified low net ecosystem productivity, hypoxia, and acidification at three outlets of the Pearl River Estuary, China.

Clarifying the influence of hydrological variations on ecological function is a topic of considerable interest in watershed ecological flow assessment and water resource management. Net ecosystem productivity (NEP) is a useful composite indicator of ecosystem function, reflecting material cycling and energy flow. However, the effects of hydrological variations on NEP, especially the influence mechanism, remain unclear due to the complex environmental characteristics in estuaries.

Integrative analysis of key candidate genes and signaling pathways in ovarian cancer by bioinformatics.

Background: Ovarian cancer is one of the most common gynecological tumors, and among gynecological tumors, its incidence and mortality rates are fairly high. However, the pathogenesis of ovarian cancer is not clear. The present study aimed to investigate the differentially expressed genes and signaling pathways associated with ovarian cancer by bioinformatics analysis.

Serum IgA/C3 ratio and glomerular C3 staining predict progression of IgA nephropathy in children.

Background: This retrospective study aimed to evaluate the significance of serum immunoglobulin A/complement 3 (IgA/C3) ratio and glomerular C3 staining at the onset of disease for predicting progression of IgA nephropathy in children.

Methods: A total of 41 children with IgA nephropathy were allocated to two groups according to proteinuria (proteinuria <50 mg/kg/day group and proteinuria ≥50 mg/kg/day group) to compare their clinical data. Receiver operating characteristic (ROC) curves were used to evaluate the optimal cutoff value of serum IgA/C3 ratio in two groups.

Enhanced peroxymonosulfate activation via complexed Mn(II): A novel non-radical oxidation mechanism involving manganese intermediates.

In recent years, the activation of persulfates (peroxydisulfate (PDS) and peroxymonosulfate (PMS)) via transition metal ions for contaminants degradation has received extensive attention in water treatment. There has been growing interest on the mechanism (radical versus non-radical pathway) of activation processes. Interestingly, in contrast to copper, iron or cobalt ions regarded as effective activators for persulfates, manganese ion (Mn(II)) is inefficient for persulfates activation.

A comparison study of levofloxacin degradation by peroxymonosulfate and permanganate: Kinetics, products and effect of quinone group.

Permanganate (Mn(VII)) as a selective oxidant has been widely used in water treatment process. Recently, peroxymonosulfate (PMS) was recognized as an emerging selective oxidant, which showed appreciable reactivity toward organic compounds containing electron-rich functional groups. In this study, the oxidation of a model fluoroquinolone antibiotic levofloxacin (LEV) by Mn(VII) and PMS was comparatively investigated.

A systematic review and meta-analysis of children with coronavirus disease 2019 (COVID-19).

To provide a comprehensive and systematic analysis of demographic characteristics, clinical symptoms, laboratory findings, and imaging features of coronavirus disease 2019 (COVID-19) in pediatric patients. A meta-analysis was carried out to identify studies on COVID-19 from 25 December 2019 to 30 April 2020. A total of 48 studies with 5829 pediatric patients were included.

Enhanced photocatalytic degradation of perfluorooctanoic acid by TiC MXene-derived heterojunction photocatalyst: Application of intercalation strategy in DESs.

In-situ construction of heterojunction photocatalyst on two-dimensional (2D) TiC MXene substrate has been proved to be a feasible method to enhance the photocatalytic degradation of organic pollutants. However, the limited interlayer spacing of 2D TiC hinders the in-situ growth of TiO photocatalyst. Herein, the intercalation strategy was developed in deep eutectic solvents (DESs) method to achieve interlayer expansion of TiC and improve TiC-derived photocatalyst performance.

Children with coronavirus disease 2019: A review of demographic, clinical, laboratory, and imaging features in pediatric patients.

There is a current outbreak of coronavirus disease 2019 (COVID-19), with a global spread. With the rapid increase in the number of infections, an increase is observed in the number of children with COVID-19. Most research findings are regarding adult cases, which are not always transferrable to children.

Component-Resolved Diagnostic Study of Egg Allergy in Northern Chinese Children.

Background: Egg component-specific IgE can be useful to evaluate and diagnose egg allergy, but their prevalence and clinical significance remain unclear in the local population. Previous studies have led to contradictory results regarding the value of specific IgG and specific IgG4 in sensitization.

Objective: We aimed to determine the level of specific IgE, IgG, and IgG4 antibodies to the major egg allergens in egg-allergic children.

Are free radicals actually responsible for enhanced oxidation of contaminants by Cr(VI) in the presence of bisulfite?

Recently, the technology for the remediation of Cr(VI) pollutant via bisulfite has been found to be effective for fast elimination of co-contaminants especially in acidic solution, where free radicals (i.e., sulfate and/or hydroxyl radicals) are proposed to act as dominant oxidants.

Carbon Materials Inhibit Formation of Nitrated Aromatic Products in Treatment of Phenolic Compounds by Thermal Activation of Peroxydisulfate in the Presence of Nitrite.

Recent studies have reported that toxic nitrated aromatic products are generated during treatment of phenolic compounds by thermally activated peroxydisulfate (thermal/PDS) in the presence of nitrite (NO). This work explored the potential of carbon materials on controlling the formation of nitrated aromatic products using phenol as a model compound. In the presence of selected carbon materials including diverse carbon nanotubes (CNT) and powdered activated carbon (PAC), the transformation kinetics of phenol was significantly enhanced, primarily attributed to nonradical activation of PDS by carbon materials.

New Insights into the Combination of Permanganate and Bisulfite as a Novel Advanced Oxidation Process: Importance of High Valent Manganese-Oxo Species and Sulfate Radical.

Recently, it has been reported that the combination of permanganate (Mn(VII)) and bisulfite can lead to a rapid degradation of organic contaminants, where soluble Mn(III) is proposed to be responsible. Interestingly, in this work, we demonstrated the involvement of high-valent Mn-oxo species (possibly Mn(V)) as well as sulfate radical in the Mn(VII)/bisulfite system, by using methyl phenyl sulfoxide (PMSO) as a chemical probe. It was found that the combination of Mn(VII) and bisulfite resulted in appreciable degradation of PMSO under various conditions, while negligible PMSO was degraded by manganese dioxide (MnO) in the presence of bisulfite under similar conditions.

Health effects of physical activity as predicted by particle deposition in the human respiratory tract.

Although health benefits of physical activity are well known, the risk of physical activity in polluted air is unclear. Our objective is to investigate health effects resulting from physical activity in polluted air by looking at particle deposition in human tracheobronchial (TB) airways. Airflow and particle deposition in TB airways were investigated using a computational fluid dynamics (CFD) method.

Prenatal exposure to ambient temperature variation increases the risk of common cold in children.

Background: Common cold is a frequent upper respiratory tract infection, but the role of ambient temperature in the infection is unclear.

Objective: We investigated the role of prenatal exposure to diurnal temperature variation (DTV), the difference between the daily maximal and minimal temperatures, in the risk of common cold in children.

Methods: We conducted a cohort study of 2598 preschool children in Changsha, China.

Maternal exposure to ambient air temperature during pregnancy and early childhood pneumonia.

Background: Pneumonia has been widely recognized as the leading cause of death in children worldwide, but its etiology still remains unclear.

Objective: We examined the association between maternal exposure to ambient air temperature during pregnancy and lifetime pneumonia in the offspring.

Methods: We conducted a cohort study of 2598 preschool children aged 3-6 years in Changsha, China.

Macular laser photocoagulation with or without intravitreal triamcinolone pretreatment for diabetic macular edema: a result from five randomized controlled trials.

Aim: To assess possible benefits of intravitreal triamcinolone acetonide (IVTA) injection as pretreatment for macular laser photocoagulation (MLP) in patients with diabetic macular edema (DME).

Methods: Published randomized controlled trials (RCTs) concerning MLP with or without IVTA pretreatment for DME were retrieved from databases CNKI, Medline, EMbase, Web of Science, and the Cochrane Library. A Meta-analysis on eligible studies was conducted using RevMan 5.

Polymorphisms in FZD3 and FZD6 genes and risk of neural tube defects in a northern Han Chinese population.

Neural tube defects (NTDs) are the most common and severe malformations of the central nervous system. The association of single nucleotide polymorphisms (SNPs) of the Frizzled 3 (FZD3) and Frizzled 6 (FZD6) genes and NTDs in the Han population of northern China was principally studied. One synonymous SNP (rs2241802) in FZD3 gene and three nonsynonymous SNPs (rs827528, rs3808553 and rs12549394) in FZD6 gene were analyzed by polymerase chain reaction (PCR) and sequencing methods in 135 NTD patients and 135 normal controls.

A new kind CO2/CH4 separation material: open ended nitrogen doped carbon nanotubes formed by direct pyrolysis of metal organic frameworks.

Unprecedented open ended nitrogen doped carbon nanotubes prepared by direct pyrolysis of [Co(HTTG)(H(2)O)(2)](n) (TTG = N,N',N''-1,3,5-triazine-2,4,6-triyltris-glycine) show among the largest surface area of multiwalled nanotubes and high CO(2)/CH(4) adsorption selectivity which increases with increasing of nitrogen content.

Experimental study on pollutant movement in surf zone.

The experiments on pollutant movement in surf zone were conducted on the two gentle beaches (with slope of 1:100 and 1:40, respectively), for diverse wave cases. The movement contours and direction of pollutants, under the action of regular and random waves with diverse wave amplitudes, were provided and studied in this paper. It was shown that, due to complicated hydrodynamics in surf zone, the pollutant movement state is quite complicated and different from that in pure current zone.

Numerical model of flow and pollutant transportation in non-orthogonal curvilinear coordinates.

The planar 2D k-epsilon double equations' turbulence model was adopted and transformed into non-orthogonal curvilinear coordinates. The concentration convection-diffusion was introduced to planar 2D SIMPLEC algorithm of flow in non-orthogonal curvilinear coordinates. The numerical model of pollutant transportation in non-orthogonal curvilinear coordinates was constructed.