Investigation of the Temperature Actions of Bridge Cables Based on Long-Term Measurement and the Gradient Boosted Regression Trees Method.

Cable-stayed bridges have been commonly used on high-speed railways. The design, construction, and maintenance of cable-stayed bridges necessitate an accurate assessment of the cable temperature field. However, the temperature fields of cables have not been well established.

Model predictive control of three-phase voltage-source converters with improved tracking performance.

The conventional finite control set-model predictive control (FCS-MPC) has not been completely embraced by the power industry because of large tracking errors and the high required sampling frequency. Therefore, the double-vector-based model predictive control (DVB-MPC), which enfolds the deadbeat control (DBC) theory, has gradually crept into researchers' horizons in recent years. In the universal DVB-MPC (UDVB-MPC) scheme, selecting two operation vectors in a single sector is a major obstacle to achieving satisfactory tracking performance.

Phytochemical Constituents of Propolis Flavonoid, Immunological Enhancement, and Anti-porcine Parvovirus Activities Isolated From Propolis.

Propolis is widely used in health preservation and disease healing; it contains many ingredients. The previous study had revealed that the ethanolic or water extracts of propolis have a wide range of efficacy, such as antiviral, immune enhancement, anti-inflammatory, and so on, but its antiviral components and underlying mechanism of action remain unknown. In this study, we investigated the chemical composition, anti-porcine parvovirus (PPV) effectiveness, and immunological enhancement of propolis flavone ethanolic extracts.

Macrophage immunomodulatory activity of nanoemulsion via activation of P65/JNK/ikkαsignaling pathway and regulation of Th1/Th2 Cytokines.

Nanoemulsions (NE) are used widely in pharmaceutical drug formulations and vaccine preparation, and (ASPS) is a natural bioactive compound with immunostimulatory activity. Therefore, NE-loaded ASPS is expected to provide immunological enhancement for effective treatment. In the present study, (ASPS was encapsulated into nanoemulsions, the resultant ASPS-NE were coated with a negative charge, and the immune enhancement mechanism of these ASPS-NE formulations was analyzed.

Sodium fluoride activates the extrinsic apoptosis via regulating NOX4/ROS-mediated p53/DR5 signaling pathway in lung cells both in vitro and in vivo.

An extensive body of research has demonstrated that pulmonary toxicity induced by fluoride is related to cell apoptosis. Although induction of death receptor-initiated extrinsic apoptosis by sodium fluoride (NaF) has been reported, its mechanism of action is still not clearly defined. Herein, we found that NaF treatment induced activation of caspase-8 in BEAS-2B cells, resulting in apoptosis, which was markedly reduced by blocking caspase-8 using small interfering RNA (siRNA).

Carboxylated nanodiamond-mediated NH-PLGA nanoparticle-encapsulated fig polysaccharides for strongly enhanced immune responses in vitro and in vivo.

Nanodiamonds (NDs), which are safe carbon nanomaterials, have been used for the transmission of DNA, proteins and drugs. The feasibility of utilizing NDs to deliver NH-PLGA nanoparticle-encapsulated fig polysaccharides for strongly enhanced immune responses has not been clearly studied. In this study, we aimed to use NDs as carriers to deliver NH-PLGA nanoparticle-encapsulated fig polysaccharides for strongly enhanced immune responses.

PEI-modified macrophage cell membrane-coated PLGA nanoparticles encapsulating Dendrobium polysaccharides as a vaccine delivery system for ovalbumin to improve immune responses.

Recently, nanoparticles have been widely used in drug and vaccine adjuvant delivery. Dendrobium devonianum Polygonatum (DP), a main biologically active ingredient isolated from Dendrobium devonianum, has been widely used in the clinic as an immunostimulant to stimulate and improve immune responses, contributing to its excellent biological activity. To increase the immune efficacy of DP, macrophage cell membrane-coated drug nanocrystals featuring homologous immune escape, targeting ability and low toxicity are in high demand.

Ferulic Acid Protects against Porcine Parvovirus Infection-Induced Apoptosis by Suppressing the Nuclear Factor-B Inflammasome Axis and Toll-Like Receptor 4 via Nonstructural Protein 1.

Background: Porcine parvovirus (PPV) infection-induced apoptosis was recently identified as an important pathological factor in PPV-induced placental tissue damage, resulting in reproduction failure. In the present study, we demonstrate the possible involvement of toll-like receptor (TLR) 4 and nuclear factor (NF)-B inflammasome activation in PPV infection-induced apoptosis and the protective potential of ferulic acid (FA). PPV infection significantly activated the expression levels of TLR4, NF-B, MyD88, and interleukin (IL)-6.

Ferulic acid isolated from propolis inhibits porcine parvovirus replication potentially through Bid-mediate apoptosis.

Propolis from honeybee hives, which is a traditional Chinese medicine, is widely used in veterinary clinics. Many compounds have been identified and isolated from propolis. Ferulic acid (FA), one of the propolis components, previous studies have proven that it has antiviral effects.

The anti-porcine parvovirus activity of nanometer propolis flavone and propolis flavone in vitro and in vivo.

Objectives. The present study was conducted to evaluate the activity of nanometer propolis flavone (NPF) on inhibiting porcine parvovirus (PPV) in vitro and in vivo. Methods.

Metal-mediated controllable creation of secondary, tertiary, and quaternary carbon centers: a powerful strategy for the synthesis of iron, cobalt, and copper complexes with in situ generated substituted 1-pyridineimidazo[1,5-a]pyridine ligands.

An efficient strategy for the synthesis of a wide variety of coordination complexes has been developed. The synthetic protocol involves a solvothermal in situ metal-ligand reaction of picolinaldehyde, ammonium acetate, and transition-metal ions, leading to the generation of 12 coordination complexes supported by a novel class of substituted 1-pyridineimidazo[1,5-a]pyridine ligands (L1-L5). The ligands L1-L5 were afforded by metal-mediated controllable conversion of the aldehyde group of picolialdehyde into a ketone and secondary, tertiary, and quaternary carbon centers, respectively.

Bis[2-(benzyl-imino-meth-yl)pyrrol-1-ido-κ(2)N,N']bis-(dimethyl-amido-κN)titanium(IV).

The mononuclear title complex, [Ti(C(2)H(6)N)(2)(C(12)H(11)N(2))(2)], was synthesized by the reaction of 1-phenyl-N-[(pyrrol-2-yl)methyl-idene]methanamine with Ti(NMe(2))(4). The Ti(IV) atom is coordinated in a distorted octa-hedral geometry by four N atoms from two derivatized methanamine ligands and two N atoms from two dimethyl-amide ions. The dihedral angles between the pyrrole and phenyl rings in the bidentate ligands are 62.