Publications by authors named "Yonglu Gong"
Article Synopsis
- - Research has found links between lipids, cerebrospinal fluid (CSF) metabolites, and Late-Onset Alzheimer's Disease (LOAD), but how they causally interact is still uncertain.
- - Using statistical data from GWAS, the study examined the causal relationship between lipids and LOAD, revealing that predicted cholesterol decreases LOAD risk, while a specific type of phosphatidylcholine increases it, with a CSF metabolite identified as a potential mediator.
- - The results emphasize the importance of CSF metabolites in understanding how lipids contribute to LOAD, suggesting they could serve as valuable biomarkers for diagnosis and prevention.
Objectives: Previous studies have indicated a correlation between cytokines and autoimmune diseases. yet the causality remains uncertain. Through Mendelian Randomization (MR) analysis, we aimed to investigate the causal relationships between genetically predicted levels of 91 cytokines and three autoimmune diseases: Multiple Sclerosis (MS), Systemic Lupus Erythematosus (SLE), and Hashimoto's Thyroiditis (HT).
View Article and Find Full Text PDFIn the germinal center (GC), follicular helper T (TFH) cells interact with B cells and undergo a series of GC reactions to ultimately produce high-affinity antibodies and memory plasma cells. Recent studies have found a subpopulation of regulatory T cells called follicular regulatory T (TFR) cells. TFR cells can inhibit TFH cells and/or B cells in a variety of ways to specifically regulate GC reactions.
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