FGFR2 modulates the Akt/Nrf2/ARE signaling pathway to improve angiotensin II-induced hypertension-related endothelial dysfunction.

Background: Fibroblast growth factor receptor (FGFR)2 expression was decreased in hypertension patients while its role in hypertension was not explored. This experiment aimed to investigate the expression ofFGFR2 in angiotensin II (Ang II)-induced human umbilical vein endothelial cells (HUVECs) and the role of FGFR2 in improving AngII-induced hypertension-related endothelial dysfunction.

Methods: AngII-induced HUVECs simulated the hypertension model in vitro.

Metabolic-Related Index to Predict Post-Transplantation Diabetes Mellitus After Kidney Transplantation.

Metabolic-related markers are novel tools for assessing insulin resistance. Early identification of post-transplantation diabetes mellitus (PTDM) before hyperglycemia can be helpful to attenuate the rapid development of diabetic complications. This article aims to explore the convenient and inexpensive values of metabolic-related markers, including TyG, TyG-BMI, TG/HDL-C, and non-HDL-C/HDL-C for predicting PTDM.

Face detection for rail transit passengers based on single shot detector and active learning.

COVID-19 spreads rapidly among people, so that more and more people are wearing masks in rail transit stations. However, the current face detection algorithms cannot distinguish between a face wearing a mask and a face not wearing a mask. This paper proposes a face detection algorithm based on single shot detector and active learning in rail transit surveillance, effectively detecting faces and faces wearing masks.

Impact of COVID-19 on domestic air transportation in China.

Assessing the impact of the coronavirus disease 2019 (COVID-19) on air transportation is essential for policymakers and airlines to prevent their widespread shutdown. The panel data observed from January 20, 2020, to April 30, 2020, were used to identify the impact of COVID-19 and the relevant control measures adopted on China's domestic air transportation. Hybrid models within negative binomial models were employed to separate the temporal and spatial effects of COVID-19.

Synthesis and pharmacological validation of fluorescent diarylsulfonylurea analogues as NLRP3 inhibitors and imaging probes.

The NOD-like receptor family pyrin domain-containing protein 3 (NLRP3) is a key cytosolic pattern recognition receptor that senses diverse pathogen- and host-originated threat signals. Aberrant activation of NLRP3 inflammasomes is closely associated with the pathogenesis of various complex inflammatory diseases. Nevertheless, the detailed regulation mechanism of NLRP3 inflammasome and its pathogenic roles in the inflammation progression remain to be fully elucidated.

Attract-Repel Encoder: Learning Anomaly Representation Away From Landmarks.

Anomaly detection (AD) has attracted great interest in the data mining community. With the development of deep learning, various deep autoencoders have been used and modified to solve AD problems due to their efficient data coding and reconstruction mechanisms. However, such methods still suffer challenges when solving some practical AD tasks.

The Properties of Different Healing Agents Considering the Micro-Self-Healing Process of Asphalt with Encapsulations.

Improving the self-healing performance of asphalt by employing encapsulation technology is a topic of wide interest. This study investigated the performance of sunflower oil, engine oil, and waste cooking oil based on the microhealing mechanism of asphalt with compartmented polymeric fiber. Capillary flow, contact angle, Brookfield viscosity, bar thin layer chromatography, and fatigue-recovery-fatigue tests were conducted to characterize the capillary flow capacity, wetting ability, viscosity reduction ability, suitability of components, and performance restoration ability of the different kinds of healing agents.

Palmatine-loaded electrospun poly(ε-caprolactone)/gelatin nanofibrous scaffolds accelerate wound healing and inhibit hypertrophic scar formation in a rabbit ear model.

Hypertrophic scar (HS) has been considered as a great concern for patients and a challenging problem for clinicians as it can cause functional debility, cosmetic disfigurement and psychological trauma. Although many methods have been developed to prevent and treat HS, the scarless healing is still a worldwide medical problem. In this study, palmatine-loaded poly(-caprolactone)/gelatin nanofibrous scaffolds (PCL/GE/PALs) were fabricated by electrospinning, and their effects on wound healing and HS formation were investigated.

Evaluating heavy metal accumulation and potential risks in soil-plant systems applied with magnesium slag-based fertilizer.

Two typical Chinese soils including southern paddy soil and northern calcareous soils were used in a pot experiment to evaluate the effect of magnesium slag-based fertilizer on heavy metal accumulation and health risk in soil-plant system. The results indicated that magnesium slag-based fertilizer promoted the growth of maize plants. The concentrations of Cr, Cu, Pb and Zn in both soils amended with magnesium slag-based fertilizer were qualified for the second level criterion of Standard of Soil Environment (GB 15618-2009).

Is exposure to aluminium adjuvants associated with social impairments in mice? A pilot study.

Background: Our group has shown that significant correlations exist between rates of Autism Spectrum Disorder (ASD) and total aluminum adjuvants given to children through vaccines in several Western countries. These correlations satisfied eight out of nine Hill criteria for causality. Experimental studies have demonstrated a range of behavioural abnormalities in young mice after postnatal exposure to aluminium.

RETRACTED: Subcutaneous injections of aluminum at vaccine adjuvant levels activate innate immune genes in mouse brain that are homologous with biomarkers of autism.

This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our-business/policies/article-withdrawal).

Synthesis of a novel slow-release potassium fertilizer from modified Pidgeon magnesium slag by potassium carbonate.

Unlabelled: A novel slow-release potassium fertilizer (SPF) was synthesized using Pidgeon magnesium slag (PMS) and potassium carbonate, which could minimize fertilizer nutrient loss and PMS disposal problems. Orthogonal experiments were conducted to determine the optimum conditions for synthesis. The potassium (K)-bearing compounds of SPF existed mainly in the form of crystalline phases Ca1.

Upregulation of ATG3 contributes to autophagy induced by the detachment of intestinal epithelial cells from the extracellular matrix, but promotes autophagy-independent apoptosis of the attached cells.

Detachment of nonmalignant intestinal epithelial cells from the extracellular matrix (ECM) triggers their growth arrest and, ultimately, apoptosis. In contrast, colorectal cancer cells can grow without attachment to the ECM. This ability is critical for their malignant potential.

Parameter estimation of fractional-order chaotic systems by using quantum parallel particle swarm optimization algorithm.

Parameter estimation for fractional-order chaotic systems is an important issue in fractional-order chaotic control and synchronization and could be essentially formulated as a multidimensional optimization problem. A novel algorithm called quantum parallel particle swarm optimization (QPPSO) is proposed to solve the parameter estimation for fractional-order chaotic systems. The parallel characteristic of quantum computing is used in QPPSO.

Oxygen enrichment and its application to life support systems for workers in high-altitude areas.

Background: Workers coming from lowland regions are at risk of developing acute mountain sickness (AMS) when working in low oxygen high-altitude areas.

Objectives: The aim of this study was to improve the conditions that lead to hypoxia and ensure the safety of the high-altitude workers. We analyzed the influence of low atmospheric pressure on the oxygen enrichment process in high-altitude areas using an engineering method called low-pressure swing adsorption (LPSA).

[The combined application of dissociate skin flap and vacuum sealing drainage on the defect of the large neck neoplasms after surgical procedures].

Objective: To evaluate the effect of the combined application of dissociate skin flap and vacuum sealing drainage (VSD) for the repairing for defect after surgical management of huge neck neoplasms.

Method: Nineteen patients with huge neck malignant tumor involving the skin of the neck were given radical operation, making use of VSD covering the wound surface. After giving 6.

[Detection and correlation of lipopolysaccharide, vitamin D receptor and matrix metalloproteinase-9 in the middle ear cholesteatoma].

Objective: To investigate the expression and concentration of lipopolysaccharide (LPS) and matrix metalloproteinase-9 (MMP-9) in middle ear cholesteatoma and discuss their relations.

Method: Twenty-nine cases of middle ear cholesteatoma tissue, 18 cases of external auditory canal tissue were detected by limulus amebocyte lysate assay (LAL-assay), and expression of MMP-9 protein in formalin-fixed, paraffin-embedded tissues was detected by immunohistochemical method.

Result: The concentrations of LPS in cholesteatoma were higher than that in external auditory canal tissues.

[Expression of MEF2D on nasopharyngeal carcinoma tissues and its influence of prognostic].

Objective: To explore the expression of MEF2D in NPC tissues, study the relationship between the expression and prognostic.

Method: Specimens from 101 NPC patients who were follow-up visited 1 to 7 years were analyzed for MEF2D by using immunohistochemistry.

Result: (1) The expression of MEF2D was higher in the higher clinical stage.

Proteomic analysis of heterosis during maize seed germination.

Heterosis is observed for most phenotypic traits and developmental stages in many plants. In this study, the embryos, from germinating seeds after 24 h of soaking, for five elite maize hybrids and their parents were selected to unravel the genetic basis of heterosis using 2-D proteomic method. In total, 257 (80.

Oncogenic ras-induced down-regulation of autophagy mediator Beclin-1 is required for malignant transformation of intestinal epithelial cells.

Detachment of non-malignant epithelial cells from the extracellular matrix causes their growth arrest and, ultimately, death. By contrast, cells composing carcinomas, cancers of epithelial origin, can survive and proliferate without being attached to the extracellular matrix. These properties of tumor cells represent hallmarks of malignant transformation and are critical for cancer progression.

Peripheral projections of NESP55 containing neurons in the rat sympathetic ganglia.

The peripheral projections of neurons expressing neuroendocrine secretory protein 55 (NESP55), a novel member of the chromogranin family, were studied by retrograde tracing technique. It was found that NESP55 positive neurons in the rat superior cervical ganglion projected to a number of targets including the submandibular gland, the cervical lymph nodes, the forehead skin, the iris, but not to the thyroid. Among these NESP55 positive target-projecting neurons, a subpopulation contained neuropeptide Y (NPY), a vasoconstrictor.

Neuroendocrine secretory protein 55 (NESP55) in the spinal cord of rat: an immunocytochemical study.

The immunohistochemical expression of a novel chromogranin-like protein, neuroendocrine secretory protein 55 (NESP55), in the rat spinal cord was investigated. NESP55-immunoreactive cells were detected in the ventral horn, intermediate laminae, and deep dorsal horn, comprising motoneurons, autonomic neurons, and interneurons throughout all spinal segments. Within laminae I-II of the dorsal horn, one or two NESP55-positive cells were often seen.