Integrating network pharmacology and multi-omics to explore the mechanism of Callicarpa kwangtungensis Chun in ameliorating Alzheimer's disease pathology in APP/PS1 mice.

Ethnopharmacological Relevance: Callicarpa kwangtungensis Chun (CK) is a traditional herb for the treatment of blood stasis, hemostasis, anti-inflammation, and antidepressant. Previous studies have showen that CK extract has significant anti-neuroinflammatory activity. However, the mechanism by which it treats AD is still unclear.

Ecological risk of Cd and Cr in the black rock series should be noticed: Based on the study of enrichment mechanism, occurrence form in the Lower Cambrian Lujiaping formation.

The heavy metals in soils developed from the black rock series originate from the parent rock, but their sources and enrichment mechanisms in the parent rock remain unclear. This study explores the enrichment mechanisms, occurrence forms, and ecological environmental effects of cadmium (Cd) and chromium (Cr) in the black rock series. Results revealed average concentrations of 1.

Genetic polymorphisms of BACH2, a key gene regulating Th2 immune response, increasing risk of allergic rhinitis.

Background: Allergic rhinitis (AR) is an allergic disease characterized by the dominant differentiation of T helper cell 2 (Th2). BACH2 plays a key role in regulating Th2 immune response. This study aimed to explore the association between BACH2 single nucleotide polymorphism (SNPs) and susceptibility to AR.

Stratum affects the distribution of soil selenium bioavailability by modulating the soil physicochemical properties: A case study in a Se-enriched area, China.

The soil selenium (Se) content and bioavailability are important for human health. In this regard, knowing the factors driving the concentration of total Se and bioavailable Se in soils is essential to map Se, enhance foodstuffs' Se content, and improve the Se nutritional status of humans. In this study, total Se and Se bioavailability (i.

The prevalence of obesity and relationship between obesity indicators and chronic diseases in Northern Shaanxi, China.

Introduction: Obesity not only affects human health but also is an important risk factor for a variety of chronic diseases. Therefore, it is particularly important to analyse the epidemic trend of obesity and actively carry out the prevention and control of obesity in the population.

Material And Methods: A total of 4565 adults were selected by multi-stage stratified random sampling in Shenmu, Shaanxi Province, China.

Prevalence and factors associated with overweight, obesity and central obesity among adults in Shenmu City, Shaanxi Province, China.

Objectives: This research aimed to explore the prevalence and determinants of overweight, obesity, and central obesity in Shenmu City, Shaanxi Province, China and to offer guidance for preventative health measures.

Methods: We conducted a multi-stage, stratified random sampling survey among 4,565 residents of Shenmu City. Data collection included questionnaires and anthropometric assessments to gather socio-demographic data and to identify cases of overweight, obesity, and central obesity.

Blood Lipid Metabolic Profiles and Causal Links to Site-Specific Cancer Risks: A Mendelian Randomization Study.

Observational and Mendelian randomization (MR) studies have established links between dyslipidemia and select cancer susceptibilities. However, there is a lack of comprehensive exploration of causal relationships spanning diverse cancer types. Here, we conducted a two-sample MR analysis to elucidate the causative connections between 9 blood lipid metabolic profiles (namely, adiponectin, leptin, lipoprotein A, apolipoprotein A1, apolipoprotein B, cholesterol, triglycerides, LDL-cholesterol, and HDL-cholesterol) and 21 site-specific cancer risks.

Simulation and prediction for the spatial heterogeneity of soil selenium bioavailability at different stratigraphic scales.

Stratigraphic lithology strongly influences the spatial heterogeneity of soil available selenium (ASe), however, it is often neglected in regional simulation. Therefore, taking the Jiangjin District, where the soil is richer in selenium (Se), as the research area, the changes of soil ASe at different spatial scales have been simulated by combining Geodetector and three popular models (Multiple linear regression (MLR), Random forest (RF) and BP neural network (BPN)). The results showed that modelling with 'Formation' as the spatial scale could reduce the influence of stratum lithology difference on the spatial heterogeneity of soil ASe and improve the model's prediction accuracy.

The Assessment of Gene Polymorphism Association with the Risk of Allergic Rhinitis in the Chinese Han Population from Northern China.

Background: Environmental factors and genetic predisposition can influence the occurrence and development of AR. Toll-like receptor 1 (TLR1) belongs to the TLR receptor family, which plays a fundamental role in the activation of innate immunity. This study aimed to explore the association between genetic loci and AR susceptibility in the Han Chinese from northern China.

Synthesis of acrylic resin and methacrylic resin microspheres by suspension polymerization.

The process of suspension polymerization was utilized to create acrylate resin microspheres with mesh numbers of 140-200 μm and particle sizes of 100 μm for implementation in mesh coating technology. The copolymer of methyl methacrylate (MMA) and methyl acrylate (MA) served as the primary polymer, with dibenzoyl peroxide (DBPO) functioning as the initiator, and a mixture of calcium carbonate and deionized water served as the dispersion medium. The surface morphology of the synthesized microspheres was analyzed through Fourier-transform infrared (FTIR) spectroscopy and scanning electron microscopy (SEM) to confirm successful synthesis.

[Analysis of Change and Driving Factors of River Environmental Quality in China from 2002 to 2020].

According to the river environmental quality, pollutant emission, and investment in environmental pollution control from 2002-2020, the change law and driving factors of river environmental quality in China were evaluated using canonical correlation analysis and the Spearman correlation coefficient to analyze the influence between environmental and pollutant emission/investment in environmental pollution control. The results indicated that the river environmental quality was improved significantly based on the proportion of Class Ⅰ-Ⅲ increasing from 29.1% to 87.

Hyperoside alleviates postmenopausal osteoporosis via regulating miR-19a-5p/IL-17A axis.

Problem: Postmenopausal osteoporosis (PMO) is a common osteoporosis. Hyperoside (Hyp), a natural flavonoid compound, has anti-osteoporotic effects, but the underlying mechanisms remain poorly understood. Inflammatory cytokine IL-17A is upregulated in PMO and plays vital roles in bone loss, but the upstream regulatory factors and mechanisms are still unknown.

Molecular Mechanism and Structure-activity Relationship of the Inhibition Effect between Monoamine Oxidase and Selegiline Analogues.

Introduction: To investigate the inhibition properties and structure-activity relationship between monoamine oxidase (MAO) and selected monoamine oxidase inhibitors (MAOIs, including selegiline, rasagiline and clorgiline).

Methods: The inhibition effect and molecular mechanism between MAO and MAOIs were identified via the half maximal inhibitory concentration (IC) and molecular docking technology.

Results: It was indicated that selegiline and rasagiline were MAO B inhibitors, but clorgiline was MAO-A inhibitor based on the selectivity index (SI) of MAOIs (0.

A rapid magnetic-based purification of Cd and Pb prior to portable electrochemical determination for grain.

How to quickly separate and detect cadmium (Cd) and lead (Pb) from solid samples is a difficult problem that needs to be solved. For this, FeO@agarose@iminodiacetic acid (IDA) was synthesized and used for rapid purification of Cd and Pb. This material can remove complex matrix interference completely within a short time of 15 min.

Emerging role of miRNAs, lncRNAs, and circRNAs in pregnancy-associated diseases.

Accumulating studies have demonstrated that non-coding RNAs (ncRNAs), functioning as important regulators of transcription and translation, are involved in the establishment and maintenance of pregnancy, especially the maternal immune adaptation process. The endometrial stromal cells (ESCs), trophoblast cells, and decidua immune cells that reside at the maternal-fetal interface are thought to play significant roles in normal pregnancy and pregnancy-associated diseases. Here, we reviewed the up-to-date evidence on how microRNA, long non-coding RNA, and circular RNA regulate ESCs, trophoblast cells, and immune cells and discussed the potential applications of these ncRNAs as diagnostic and therapeutic markers in pregnancy complications.

Association between polymorphisms of the gene and allergic rhinitis risk in the Chinese population: a case-control study.

Background: Allergic rhinitis (AR) is a great risk factor for developing asthma, and its pathogenesis is affected by various factors, such as gene and environment. is related to allergic diseases. Our purpose is to explore the correlation of single nucleotide polymorphisms (SNPs) in and AR risk in the Chinese population.

[Soil Heavy Metal Content, Pollution, and Influencing Factors in Typical Farming Area of Sichuan Basin].

In order to identify heavy metal contents, the pollution characteristics and influencing factors of soil in typical farming areas in the Sichuan basin were analyzed, with Jiangjin District of Chongqing City chosen as the study area. Two hundred and forty-seven topsoil samples were collected and analyzed using the Nemerow index (NPI), geographical information system (GIS), and geodetector method. The results demonstrated that: 1 the arithmetic means of Cd, Cu, and Zn in the topsoil were 1.

variants conferred a decreased risk to allergic rhinitis in the Chinese population.

Allergic rhinitis (AR) is a chronic respiratory disease. Hereditary factors played a key role in the pathogenesis of the AR. This study investigated the association between variants and AR risk in the Chinese population.

The emerging roles of TLR and cGAS signaling in tumorigenesis and progression of ovarian cancer.

Ovarian cancer is fatal to women and has a high mortality rate. Although on-going efforts are never stopped in identifying diagnostic and intervention strategies, the disease is so far unable to be well managed. The most important reason for this is the complexity of pathogenesis for OC, and therefore, uncovering the essential molecular biomarkers accompanied with OC progression takes the privilege for OC remission.

Automated and Rapid Easy-to-Use Magnetic Solid-Phase Extraction System for Five Heavy Metals in Cereals and Feeds.

A rapid, accurate, and ecofriendly pretreatment plays an extremely important role prior to ICP-MS for heavy metal analysis. In order to improve the pretreatment efficiency, a high-throughput and automatic magnetic solid-phase extraction of five heavy metals (Cd, Pb, Mn, Cu, and Zn) was carried out by a magnet-controlled pretreatment system with an ecofriendly diluted acid as an extracting agent and carboxyl-functionalized magnetic beads as a pretreatment material. Key conditions, including the pH, adsorption time, and eluent solution, were optimized.

Investigating genetic causal relationships between blood pressure and anxiety, depressive symptoms, neuroticism and subjective well-being.

Background: High blood pressure is a leading cardiovascular disease risk factor and considered to be associated with psychological factors. However, the causal relationships between blood pressure and anxiety, depressive symptoms, neuroticism and subjective well-being are not clear.

Aims: The current study explored the genetic causal relationships between blood pressure and anxiety, depressive symptoms, neuroticism and subjective well-being.

Integrating network pharmacology and an experimental validation strategy elucidates the protective effect and mechanism of callicarpa nudiflora against neuroinflammation.

Abnormal activation of microglia promotes neuroinflammation (NI) in Alzheimer's disease (AD). Callicarpa nudiflora Hook . (CN) is a traditional Chinese herb with a wide range of clinical applications and definite anti-inflammatory effects.

Evidence that the pituitary gland connects type 2 diabetes mellitus and schizophrenia based on large-scale trans-ethnic genetic analyses.

Background: Previous studies on European (EUR) samples have obtained inconsistent results regarding the genetic correlation between type 2 diabetes mellitus (T2DM) and Schizophrenia (SCZ). A large-scale trans-ethnic genetic analysis may provide additional evidence with enhanced power.

Objective: We aimed to explore the genetic basis for both T2DM and SCZ based on large-scale genetic analyses of genome-wide association study (GWAS) data from both East Asian (EAS) and EUR subjects.