Design of a High-Power Nanosecond Electromagnetic Pulse Radiation System for Verifying Spaceborne Detectors.

The Spaceborne Global Lightning Location Network (SGLLN) serves the purpose of identifying transient lightning events occurring beneath the ionosphere, playing a significant role in detecting and warning of disaster weather events. To ensure the effective functioning of the wideband electromagnetic pulse detector, which is a crucial component of the SGLLN, it must be tested and verified with specific signals. However, the inherent randomness and unpredictability of lightning occurrences pose challenges to this requirement.

Clustering index analysis on EMG-Torque relation-based representation of complex neuromuscular changes after spinal cord injury.

Spinal cord injury (SCI) resulting in complex neuromuscular pathology is not sufficiently well understood. To better quantify neuromuscular changes after SCI, this study uses a clustering index (CI) method for surface electromyography (sEMG) clustering representation to investigate the relation between sEMG and torque in SCI survivors. The sEMG signals were recorded from 13 subjects with SCI and 13 gender-age matched able-bodied subjects during isometric contraction of the biceps brachii muscle at different torque levels using a linear electrode array.

Comparison of OPPO Watch Sleep Analyzer and Polysomnography for Obstructive Sleep Apnea Screening.

Objective: To evaluate the clinical performance of the OPPO Watch (OW) Sleep Analyzer (OWSA) on OSA screening with polysomnography reference.

Methods: We recruited 350 participants using OWSA and PSG simultaneously in a sleep laboratory. The respiratory event index (REI) derived from OWSA and the apnea-hypopnea index (AHI) provided by PSG were compared.

High-Efficiency Pure Blue Circularly Polarized Phosphorescence from Chiral -Heterocyclic-Carbene-Stabilized Copper(I) Clusters.

Circularly polarized luminescence (CPL) materials have attracted considerable attention for their promising applications in encryption, chiral sensing, and three-dimensional (3D) displays. However, the preparation of high-efficiency, pure blue CPL materials remains challenging. In this study, we reported an enantiomeric pair of triangle copper(I) clusters (/) rigidified by employing chiral -heterocyclic carbene (NHC) ligands with two pyridine-functionalized wingtips.

Constructing Highly Reliable and Adaptive Primary Explosive Composites for Micro-Initiator Assisting by a Hybrid Template of Metal-Organic Frameworks and Cross-Linked Polymers.

Primary explosive, as a reliable initiator for secondary explosives, is the central component of micro-initiators for modern aerospace systems and military operations. However, they are typically prepared as powders, posing potential safety risks because of the inevitable particles scattering issues in the actual working environments. Here, the fabrication of a highly adaptive bulk material of copper azide (CA)-based safe primary explosive for micro-initiators is demonstrated.

Validation of a wearable forehead sleep recorder against polysomnography in sleep staging and desaturation events in a clinical sample.

Study Objectives: Wearable sleep recording devices may be a helpful alternative method for polysomnography (PSG) due to their higher accessibility and comfort as well as lower cost, but their validities need to be examined. The aim of this study was to evaluate the accuracy of a novel single-channel, electroencephalography-based wearable forehead sleep recorder (UMindSleep) to assess sleep staging and oxygen desaturation.

Methods: Two hundred and three Chinese adults recruited from a sleep medicine center underwent an overnight study wearing UMindSleep and PSG simultaneously.

Ketone Body Improves Neurological Outcomes after Cardiac Arrest by Inhibiting Mitochondrial Fission in Rats.

Ketone bodies including -hydroxybutyrate (-HB) have been proved the therapeutic potential in diverse neurological disorders. However, the role of -HB in the regulation of neurological injury after cardiac arrest (CA) remains unclear. We investigated the effect of -HB on brain mitochondrial dysfunction and neurological function after CA.

Protective Effect of Willd. Ethanol Extract on Isoniazid-Induced Liver Injury in the Zebrafish Model.

Objective: This study aims to investigate the hepatoprotective effect and molecular mechanism of Willd. ethanol extract (HDWE) against isoniazid (INH)-induced liver injury in the zebrafish model.

Methods: INH-induced liver injury model was established by adding an immersion bath of INH in 3 days post-fertilisation (dpf) healthy transgenic zebrafish with liver-specific fluorescence (L-FABP: EGFP).

Aminal-Linked Porphyrinic Covalent Organic Framework for Rapid Photocatalytic Decontamination of Mustard-Gas Simulant.

Covalent organic frameworks (COFs) are appealing photocatalysts for toxic chemical degradation. Great efforts have been devoted to regulate the photocatalytic performance of COFs by tuning their organic building blocks, but the relationship between COF linkage and photochemical properties has rarely been explored. Herein, we report the synthesis and characterisation of a novel aminal-linked porphyrinic COF, namely Por-Aminal-COF.

Plasma and Intrapulmonary Pharmacokinetics, and Dosage Regimen Optimization of Linezolid for Treatment of Gram-Positive Cocci Infections in Patients with Pulmonary Infection After Cerebral Hemorrhage.

Purpose: The objective of this study was to perform pharmacokinetics/pharmacodynamics (PK/PD) analysis of linezolid in patients with intracerebral hemorrhage and to provide suggestions regarding dosing and treatment regimens.

Patients And Methods: Ten patients with cerebral hemorrhage and pulmonary infection were enrolled in this study. Plasma and sputum samples were obtained at specific time points after the seventh infusion.

Brain-derived Neurotrophic Factor and Its Applications through Nanosystem Delivery.

Brain-derived neurotrophic factor () is a protein that performs a neurotrophic function. and its receptors are widely expressed in the nervous system and can promote the growth of neurons and the formation of neuronal synapses in the brain. Studies have shown that a lack of can lead to impairment of memory and cognitive functions, indicating that plays an important role in mental illness and neurodegenerative diseases.

Isolation, purification, structural characteristics, pharmacological activities, and combined action of Hedyotis diffusa polysaccharides: A review.

Hedyotis diffusa polysaccharides, as the main component and an important bioactive substance of Hedyotis diffusa, are effective immunomodulators with various pharmacological activities, including antitumour, anti-inflammatory, antioxidant, anti-fatigue and immunity-enhancing activities. The total polysaccharides extracted from Hedyotis diffusa and Scutellaria barbata have great effects in treating liver cancer, gastric cancer, rectal cancer, glioma and nasopharyngeal carcinoma. Moreover, different materials and extraction methods result in differences in the structure and bioactivity of Hedyotis diffusa polysaccharides.

Knockdown of miR-203a-3p alleviates the development of bronchopulmonary dysplasia partly via the up-regulation of vascular endothelial growth factor A.

Bronchopulmonary dysplasia (BPD) is characterized by impaired vascular and alveolar development, and the underlying molecular mechanisms have remained elusive. MicroRNAs are important players in various biological functions including the pathogenesis of BPD. The present study aimed to examine the expression of miR-203a-3p in the peripheral blood of BPD patients and elucidate the mechanisms underlying miR-203a-3p-mediated progression of BPD.

A viologen-based multifunctional Eu-MOF: photo/electro-modulated chromism and luminescence.

A novel viologen-based multifunctional Eu-MOF was obtained by integrating a luminescent component Eu(NO)·6HO and a viologen-functionalized ligand. The Eu-MOF not only exhibited reversible photochromic and electrochromic properties, but also displayed photoluminescent and electroluminochromic properties.

Polysaccharides from Hedyotis diffusa enhance the antitumor activities of cytokine-induced killer cells.

Hedyotis diffusa is a well-known traditional Chinese herbal medicine. The polysaccharides extracted from H. diffusa (HDP) exhibit a range of pharmacological activities.

One-step MOF-derived Co/CoS nanoparticles embedded in nitrogen, sulfur and oxygen ternary-doped porous carbon: an efficient electrocatalyst for overall water splitting.

Co/Co9S8 nanoparticles encapsulated in a N, S, and O ternary-doped carbon matrix were synthesized utilizing a Co-NSOMOF as a single precursor, and they exhibited excellent bifunctional electrocatalytic activity for the OER and HER. Impressively, the water splitting cell exhibited a low cell voltage of 1.56 V at 10 mA cm-2.

Diverse dissolution-recrystallization structural transformations and sequential Förster resonance energy transfer behavior of a luminescent porous Cd-MOF.

Metal-organic frameworks (MOFs) with light-harvesting building blocks provide an excellent platform to study energy transfer in networks with well-defined structures. Here, we report the synthesis, dissolution-recrystallization structural transformation (DRST) and the Förster resonance energy transfer (FRET) properties of a 2D microporous MOF {[Cd(L)(Hdabco)]·5DMAc·6HO} (Cd-MOF, 1). Complex 1 can be dissolved in water and three other products with different dimensions recrystallized from the aqueous solution under diverse reaction conditions were obtained.

Association between IFN-γ genetic polymorphisms and susceptibility to hepatitis B virus infection: A meta-analysis.

Background: Hepatitis B virus (HBV) infection has become a global health burden because of its contagious mode of transmission and the resultant long-term liver damage.

Aim: To investigate how the polymorphisms of the IFN-γ gene, particularly the IFN-γ +874T/A (rs2430561) single nucleotide polymorphism (SNP), influence susceptibility to HBV infection.

Subjects And Methods: Relevant articles were identified by a comprehensive literature search covering the following computerised bibliographic databases.

Clinical and virological profiling of sporadic hepatitis E virus infection in China.

Objectives: Recently, genotype 4 HEV (HEV-4) associated hepatitis E has overtaken HEV-1 infections in China, but few studies reported the clinical and virological features of HEV-4 infection.

Methods: Sixty-two patients with acute hepatitis E (AHE) were enrolled from three hospitals in China. Clinical profiles and epidemiological records were analyzed.

Serum transforming growth factor beta 3 predicts future development of nonalcoholic fatty liver disease.

Transforming growth factor beta 3 (TGFb3) was mainly expressed by liver satellite cells in the normal liver, but it may be expressed by various liver cells during liver diseases, e.g. hepatitis and cirrhosis.

[Advances in study of dioscin--a natural product].

Dioscin, a typical saponin, is widely present in the family of Dioscoreaceae, Liliaceae, Caryophyllaceae and Rosaceae, especially in Dioscoreaceae, including Discorea nipponica Makino, Dioscorea zingiberensis C. H. Wright and Dioscorea panthaica Prain et Burkill.

A meta-analysis of the correlation between the HLA-DRB1*03 allele and chronic hepatitis B in the Han Chinese population.

Objective: This study sought to use a meta-analysis approach to comprehensively evaluate correlations between the human leukocyte antigen-DR beta 1 (HLA-DRB1)*03 allele and chronic hepatitis B (CHB) in the Han Chinese population.

Methods: The China Biomedical Literature database (CBMdisc), the Chongqing VIP database (VIP), and the PubMed database were searched. Using the inclusion and exclusion criteria of this study, all relevant case-control studies retrieved in these searches that satisfied the conditions of this investigation were collected.

A multifunctional 3D chiral porous ferroelectric metal-organic framework for sensing small organic molecules and dye uptake.

A flexible aromatic multicarboxylate ligand and Cd(II) ions assemble into a chiral multihelical porous metal-organic framework with second-order nonlinear optical and ferroelectric properties. The obtained guest-free form highly selectively senses small organic molecules and adsorbs large dye molecules.