Publications by authors named "Yongli Situ"
and as potential prognostic and therapeutic targets for adrenocortical carcinoma.
Cancer Biol Ther
December 2024
Article Synopsis
- Cadherin 2 (CDH2) and Cadherin 13 (CDH13) significantly influence the progression and prognosis of various cancers, but their specific roles in adrenocortical carcinoma (ACC) are not well understood.
- In a study of 75 ACC patients, CDH2 was found to be downregulated and CDH13 upregulated, affecting patient prognosis and showing a complex network of interactions with neighboring genes related to tumor development and metabolism.
- Moreover, CDH13 expression correlated positively with immune cell infiltration in ACC, and treatments like anti-PD1 immunotherapy were shown to alter its expression; thus, CDH2 and CDH13 may be viable targets for
Tri-Circulator (TC) is a product comprising coenzyme Q10 (CoQ10), Salvia miltiorrhiza, and Panax notoginseng. Individually, each of these constituents has demonstrated protective effects on myocardial injury. The purpose of this study is to evaluate the protective efficacy of TC on heart function and compare the differential effects between CoQ10 and TC.
View Article and Find Full Text PDFas a Potential Therapeutic Target for Renal Cell Carcinoma.
Front Biosci (Landmark Ed)
September 2023
Background: Serine hydroxymethyltransferase () is a serine-glycine-one-carbon metabolic enzyme in which and encode the cytoplasmic and mitochondrial isoenzymes, respectively. and are key players in cancer metabolic reprogramming, and thus are attractive targets for cancer therapy. However, the role of in patients with renal cell carcinoma (RCC) has not been fully elucidated.
View Article and Find Full Text PDFLiver cirrhosis following oxaliplatin-based adjuvant chemotherapy for rectal cancer.
J Oncol Pharm Pract
September 2023
Introduction: Oxaliplatin is a third-generation platinum-based antineoplastic drug that is widely used to treat patients with colorectal cancer. Reported adverse reactions include hepatic sinusoidal obstruction syndrome and liver fibrosis, but there are few reports of cirrhosis associated with chemotherapy. In addition, the pathogenesis of cirrhosis remains unclear.
View Article and Find Full Text PDFArticle Synopsis
- - The study investigates the role of the BET family (BRD2, BRD3, BRD4) in adrenocortical carcinoma (ACC), focusing on their expression levels, prognostic significance, and gene regulatory networks, revealing their potential as therapeutic targets.
- - Analysis using various online databases showed that BRD2 and BRD3 are significantly overexpressed in ACC patients, with their expression correlating with cancer stage and lower expression linked to better survival rates.
- - The research highlights the complex interactions between BRD family genes and their surrounding genetic network, indicating a significant frequency of alterations and potential pathways involved in ACC progression.
PYCR in Kidney Renal Papillary Cell Carcinoma: Expression, Prognosis, Gene Regulation Network, and Regulation Targets.
Front Biosci (Landmark Ed)
December 2022
Background: Pyrroline-5-carboxylate reductase (PYCR) includes three human genes encoding three isozymes, , , and (or ), which facilitate the final step in the conversion of glutamine to proline. These genes play important roles in regulating the cell cycle and redox homeostasis as well as promoting growth signaling pathways. Proline is abnormally upregulated in a variety of cancers, and as the last key enzyme in proline production, PYCR plays an integral role in promoting tumorigenesis and cancer progression.
View Article and Find Full Text PDFArticle Synopsis
- Tumor angiogenesis, driven by factors like CXC chemokines and VEGFA, is critical in the development and spread of colon adenocarcinoma (COAD), making understanding their regulatory network essential for treatment insights.
- A comprehensive analysis using various databases uncovered overexpressed and underexpressed genes within the CXC chemokine-VEGFA network in COAD, highlighting their correlation with tumor stages and patient survival outcomes.
- The study revealed a complex regulatory network and identified key transcription factors and miRNAs involved in gene regulation, emphasizing their potential as therapeutic targets in COAD management.
Background: Fragile histidine triad () is a strong tumor suppressor gene, and cells deficient in are prone to acquiring cancer-promoting mutations. Due to its location, deletions within are common in cancer. Over 50% of cancers show loss of expression.
View Article and Find Full Text PDFBackground: VEGFA is one of the most important regulators of angiogenesis and plays a crucial role in cancer angiogenesis and progression. Recent studies have highlighted a relationship between expression and renal cell carcinoma occurrence. However, the expression level, gene regulation network, prognostic value, and target prediction of in renal cell carcinoma remain unclear.
View Article and Find Full Text PDFObjectives: This study aimed to discover the active compounds of Sophora flavescens Ait. (SF), the anti-itch effects and underlying mechanisms of oxymatrine (OMT), one of the bioactive compounds from SF.
Methods: Dorsal root ganglion cell membrane immobilized chromatography was used to screen potential anti-pruritic active compounds from SF.