Publications by authors named "Yongjun Wu"

Lead-free BiFeO-based (BF) materials with colossal spontaneous polarization and high Curie temperatures exhibit considerable potential for groundbreaking developments in dielectric capacitors. However, their inherent limitations, such as restricted breakdown strength (E) and pronounced remanent polarization, critically restrict advancements in energy storage capabilities. Herein, we achieve an exceptional recoverable energy density of 12.

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Introduction: Allergic rhinitis (AR) is a systemic immune inflammatory response disease of the nasal mucosa. Current treatment strategies for AR are limited, owing to a lack of safety and the inability to cure the condition completely. Xiaoqinglong decoction (XQLD), a classical chinese medicine prescription, is widely used to treat AR with a good curative effect.

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H. Lév. & Vaniot () is a perennial herb belonging to the Asteraceae family and is a medicinal plant widely used in traditional medicine.

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The AP2/ERF transcription factor CaERF2 in pepper enhanced salt tolerance by scavenging reactive oxygen species. The effects of salt stress on plant development and progression are substantial. Ethylene response factor transcription factors (TFs) play a crucial role in responses to salt stress.

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Circular RNAs (circRNAs), as a class of noncoding RNA molecules with a circular structure exhibit high stability and spatiotemporal-specific expression, making them ideal cancer biomarkers for liquid biopsy. Herein, a new photoelectrochemical (PEC) biosensor for a highly sensitive circRNA assay in the whole blood of lung cancer patients was designed based on CRISPR/Cas13a-programmed Cu nanoclusters (Cu NCs) and a -scheme covalent organic framework/silver sulfide (T-COF/AgS) composite. This -scheme T-COF/AgS composite accelerates electron transfer and produces an excellent initial photocurrent.

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Background: Accurate preoperative prediction of vascular invasion in breast cancer is crucial for surgical planning and patient management. MRI radiomics has shown promise in enhancing diagnostic precision. This study aims to evaluate the effectiveness of integrating MRI radiomic features with clinical data using a deep learning approach to predict vascular invasion in breast cancer patients.

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Background: DNA methylation catalyzed by various DNA methyltransferases (DNA MTases) is one of the important epigenetic regulations in both eukaryotes and prokaryotes. Therefore, the detection of DNA MTase activity is a vital target and direction in the study of methylation-related diseases.

Results: In this study, an ultrasensitive and robust strategy was developed for DNA MTase activity sensing based on bifunctional probe propelling multipath strand displacement amplification and CRISPR/Cas12a techniques.

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The composition in ferroelectric oxide films is decisive for optimizing properties and device performances. Controlling a composition distribution in these films by a facile approach is thus highly desired. In this work, we report a solution epitaxy of PbZrTiO films with a continuous gradient of Zr concentration, realized by a competitive growth at ~220 °C.

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Chemotherapy-induced diarrhea (CID) is a common and harmful side effect of chemotherapy, greatly impacting patients' quality of life and potentially compromising their chances of survival. Disruption of the balance in intestinal microbiota and compromised integrity of the intestinal barrier are key factors contributing to CID caused by mucositis. This paper investigated the mechanism through which intestinal microbiota activate Toll-like receptors and STING pathways to mediate intestinal mucosal inflammation resulting from immune responses in the gut, uncovering a novel mechanism of intestinal microbiota in chemotherapy-induced diarrhea, and suggesting innovative approaches for the prevention and management of CID.

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Article Synopsis
  • Detecting circulating tumor cells (CTCs) is tough because they are present in low numbers and vary in characteristics, with traditional methods struggling for those with low EpCAM expression.
  • This study introduces a new approach using silica-coated magnetic nanobeads with streptavidin for better CTC capture.
  • The new method showed higher capture rates for specific cancer cell lines, especially those with low EpCAM expression, indicating its potential for improving CTC detection compared to existing commercial options.
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The identification of DNA methylation at specific sites is crucial for the early detection of cancer since DNA methylation is intimately associated to the occurrence and development of cancer. Herein, two types of sensors that can detect site-specific DNA methylation were developed to meet practical requirements using methylation sensitive restriction endonuclease and CRISPR/Cas12a. To accomplish rapid detection of target, an AciI-mediated CRISPR/Cas12a assay was developed by coupling AciI to recognize DNA methylation with Cas12a to identify site-specific DNA.

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Exotic polar topologies such as polar skyrmions have been widely observed in ferroelectric superlattice systems. The dynamic motion of polar skyrmions under external forces holds promise for applications in advanced electronic devices such as race-track memory. Meanwhile, the polar skyrmion motion has proven to be challenging due to the strong skyrmion-skyrmion interaction and a lack of a mechanism similar to the spin-transfer torque.

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The oxygen evolution reaction (OER) plays a crucial role in water electrolysis and renewable energy conversion processes. Descriptors are utilized to elucidate the structure-performance relationships of OER catalytic materials, yet each descriptor exhibits specificity to particular systems. Currently, there is a lack of effective descriptors to describe the relationship between electronic structure and OER performance in ionic systems.

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The gene, a member of the (xyloglucan endotransglycosylase/hydrolase) family, plays a crucial role in plant responses to environmental stress. In this study, we heterologously expressed the melon gene in to generate overexpressing transgenic lines, thereby elucidating the regulatory role of in water stress tolerance. Using these lines of (OE1 and OE2) and wild-type (WT) as experimental materials, we applied water stress treatments (including osmotic stress and soil drought) and rewatering treatments to investigate the response mechanisms of melon in under drought stress from a physiological and biochemical perspective.

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In this study, 12 pairs of tautomeric flavonol derivatives containing quinoxaline were synthesized. The results of antifungal activity showed that in the enol-keto tautomerism, the target compounds containing keto ( series) had better inhibitory activity against (.) than compounds containing enol ( series).

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Article Synopsis
  • A new fluorescent aptasensor technique using nicking endonuclease signal amplification (NESA) allows for the simultaneous detection of carcinoembryonic antigen (CEA) and alpha fetoprotein (AFP) from a single sample.
  • The method utilizes two specific aptamers linked to magnetic nanoparticles, which, when CEA and AFP bind, release DNA that triggers a fluorescence signal, allowing researchers to measure concentrations of these biomarkers.
  • The aptasensor demonstrated a wide detection range and low limits of detection for both CEA (0.7 ng/mL) and AFP (2 ng/mL), showing promise for early cancer screening through the simultaneous measurement of multiple tumor markers.
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Purpose: Non-alcoholic fatty liver disease (NAFLD) represents a significant global health burden, exhibiting a strong correlation with insulin resistance, obesity, and type 2 diabetes (T2DM). Despite the severity of hepatic steatosis in T2DM patients, no specific drugs have been approved for clinical treatment of the disease. Tangerine peel is one kind of popular functional food and reported to possess hypoglycemic and lipid-lowering potential.

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Circulating tumor cells (CTCs) are detected in approximately 30% of metastatic non-small-cell lung cancer (NSCLC) cases using the CellSearch system, which relies on EpCAM immunomagnetic enrichment and Cytokeratin detection. This study evaluated the effectiveness of immunomagnetic enrichment targeting oncofetal chondroitin sulfate (ofCS) using recombinant VAR2CSA proteins (rVAR2) to improve the recovery of different NSCLC cell lines spiked into lysed blood samples. Four NSCLC cell lines-NCI-H1563, A549, NCI-H1792, and NCI-H661-were used to assess capture efficiency.

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Background: Increasing evidence supports the association between impaired oral health and elevated mortality. However, there is currently a lack of research on the impact of tooth loss and periodontal disease on survival outcomes in cancer survivors. This study aims to clarify the effect of tooth loss and periodontitis on all-cause mortality on cancer survivors.

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Article Synopsis
  • The study investigates the aroma compounds in fermented soybeans known for their soy sauce-like scent, striving to identify key contributors to this aroma.
  • Researchers constructed three mutant strains from a specific strain (BJ3-2) and analyzed how these variants differed in aroma intensity.
  • Through various analytical techniques, they identified 12 primary aroma compounds, emphasizing that roasted and smoky scents are significant attributes, with pyrazines and guaiacol being crucial in defining the flavor profile.
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Unsustainable straw treatment methods detrimentally affect the environment and ecology. Aerobic fermentation (AE) and anaerobic fermentation (AN) are environmentally friendly treatments that better utilise straw resources. In this study, high-throughput sequencing was used to investigate the effects of AE and AN on nutrient content and microbial community structure during tomato straw fermentation.

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Molecular ferroelectrics have garnered significant attention due to their structural tunability, low synthesis temperature, and high flexibility. Herein, we successfully synthesized imidazole perchlorate (ImClO) single crystals and high-quality, highly-oriented thin films on Si substrates. These films demonstrated a high inverse piezoelectric coefficient of 55.

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Abnormal expression in long noncoding RNAs (lncRNAs) is closely associated with cancers. Herein, a novel CRISPR/Cas13a-enhanced photocurrent-polarity-switching photoelectrochemical (PEC) biosensor was engineered for the joint detection of dual lncRNAs, using deep learning (DL) to assist in cancer diagnosis. After target lncRNA-activated CRISPR/Cas13a cleaves to induce DNAzyme bidirectional walkers with the help of cofactor Mg, nitrogen-doped carbon-Cu/CuO octahedra are introduced into the biosensor, producing a photocurrent in the opposite direction of CdS quantum dots (QDs).

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The CRISPR/Cas12a system is increasingly used in biosensor development. However, high background signal and low sensitivity for the non-nucleic acid targets detection is challenging. Here, a padlock activator which could inhibit the trans-cleavage activity of CRISPR/Cas12a system in the intact form by steric hindrance effect (PAIT effect) was designed for non-nucleic acid targets detection.

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Synopsis of recent research by authors named "Yongjun Wu"

  • - Yongjun Wu's recent research focuses on plant stress tolerance mechanisms, innovative antifungal compounds, and advanced detection methods for biomedical applications, highlighting his multidisciplinary approach in the fields of agriculture, medicine, and biotechnology.
  • - Notable insights include the role of a xyloglucan endotransglycosylase gene in enhancing drought stress tolerance in melons, the development of flavonol derivatives with potent antifungal activity, and a novel "one-pot" biosensor for simultaneous tumor marker detection.
  • - Additionally, Wu's studies explore the therapeutic potential of tangerine peel-derived nanovesicles in treating hepatic steatosis linked to type 2 diabetes, and employ genetic techniques to improve soy sauce aroma profiles through fermentation.

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