Publications by authors named "Yongju Cho"
Article Synopsis
- Attempts to develop drugs targeting the corticotropin-releasing hormone receptor 1 (CRFR) for stress-related therapy have not been successful so far.
- High-resolution studies using X-ray free-electron lasers (XFELs) aided in understanding GPCR structures, leading to the elucidation of the CRFR's crystal structure with a specific antagonist.
- Two new antagonists, BMK-C203 and BMK-C205, were developed, with BMK-C205 showing significant antidepressant effects in mice, suggesting potential for effective drug development against CRFR.
Five bacterial species, capable of degrading the recalcitrant organic compounds (ROCs) diethyleneglycol monomethylether (DGMME), 1-amino-2-propanol (APOL), 1-methyl-2- pyrrolidinone (NMP), diethyleneglycol monoethylether (DGMEE), tetraethyleneglycol (TEG), and tetrahydrothiophene 1,1-dioxide (sulfolane), were isolated from an enrichment culture. Cupriavidus sp. catabolized 93.
View Article and Find Full Text PDFIn this study, genetic analysis was conducted to investigate the association of angiotensin I converting enzyme (ACE) gene polymorphism with clinical phenotype based on differentiation-syndrome of bronchial asthma patients. Differentiation-syndrome is a traditional Korean medicine (TKM) theory in which patients are classified into a Deficiency Syndrome Group (DSG) and an Excess Syndrome Group (ESG) according to their symptomatic classification. For this study, 110 participants were evaluated by pulmonary function test.
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