Publications by authors named "Yongjin Cai"
Article Synopsis
- Krotzkopf verkehrt (kkv) is an enzyme essential for chitin synthesis in Drosophila, affecting various tissues like the epidermis and trachea.
- Researchers conducted RNA interference analyses to identify genes that regulate kkv transcription, discovering 537 potential regulators in a genome-wide screen.
- Out of these, six genes were validated to play a role in kkv regulation, highlighting a complex interaction network that influences chitin biosynthesis and revealing new insights into kkv's transcriptional control.
Biomarkers of rheumatoid arthritis-associated interstitial lung disease.
Arthritis Rheumatol
January 2015
Objective: Interstitial lung disease (ILD) is a relatively common extraarticular manifestation of rheumatoid arthritis (RA) that contributes significantly to disease burden and excess mortality. The purpose of this study was to identify peripheral blood markers of RA-associated ILD that can facilitate earlier diagnosis and provide insight regarding the pathogenesis of this potentially devastating disease complication.
Methods: Patients with RA who were enrolled in a well-characterized Chinese identification cohort or a US replication cohort were subclassified as having RA-no ILD, RA-mild ILD, or RA-advanced ILD, based on high-resolution computed tomography scans of the chest.