Integrating restoration and interactive exploration to enhance cultural heritage through VR storytelling.

Redtory was transformed from an old industrial site into a creative park in Guangzhou. Unfortunately, it was demolished in May 2019. It holds a dual significance, representing both Guangzhou's old industrial era and its first creative park (Art and Design).

IRF4 Suppresses Osteogenic Differentiation of Periodontal Ligament Stem Cells by Activating IL-18 Signaling Pathway in Periodontitis.

The present study aims to investigate the role of interferon regulatory factor 4 (IRF4) in osteogenic differentiation of periodontal ligament stem cells (PDLSCs) and analyze the underlying signaling of these processes. In this study, IRF4 is upregulated in periodontitis periodontal ligament tissues, as compared to healthy periodontal ligament tissues. IRF4 knockdown increases cell proliferation, decreases levels of tumor necrosis factor-alpha, interleukin-6, and interleukin-8, enhances osteogenic activity, and increases the expression of RUNX family transcription factor 2, Collagen I, and Osteocalcin in PDLSCs.

Complications analysis of Ilizarov bone transport technique in the treatment of tibial bone defects-a retrospective study of 199 cases.

Background: The clinical treatment of long bone defets in the extremities caused by trauma, infection, tumours, and nonunion has been a challenge for orthopaedic surgeons. Bone transport techniques have become the only way to treat such bone defects. However, inevitable difficulties and complications related to bone transport techniques have been reported in many studies.

Electroactive Hydrogels with Photothermal/Photodynamic Effects for Effective Wound Healing Assisted by Polydopamine-Modified Graphene Oxide.

Antibacterial hydrogel wound dressings have attracted considerable attention in recent years. However, bacterial infections can occur at any point during the wound-healing process. There is a demand for hydrogels that possess on-demand antibacterial and excellent wound repair properties.

[Establishment of Evaluation System for Medical Optical Radiation Protective Eyewears].

As a kind of class II medical device, medical optical radiation protective eyewears should meet the requirements of safety and effectiveness. In this study, the evaluation system of medical optical radiation protective eyewears is established. Combined with the medical device registration unit division guidelines, the classification method of medical optical radiation protective eyewears is given.

[Study on Clear Optic Evaluation Method of Intraocular Lenses].

The study explored the methods of determining the diameter of clear optic of intraocular lenses by analyzing the design principles and influencing factors of clear optic. Measure and compare the clear optic diameters of intraocular lenses from -10.0 D to 36.

Circ_0072995 Promotes Ovarian Cancer Progression Through Regulating miR-122-5p/SLC1A5 Axis.

Ovarian cancer is a common cancer affecting women with high morbidity and mortality globally. Circular RNAs (circRNAs) have been found play vital roles in multifarious cancers, including OC. This study aims to explore the biological role and underlying mechanism of circ_0072995 in OC progression.

Generation of two induced pluripotent stem cell lines SPPHi001-A and SPPHi002-A from a Huntington's disease family of Southwestern China.

The Huntington's disease (HD) is still a devastating neurological disease without a specific cure. In this report, the peripheral blood mononuclear cells (PBMCs) from two members of a HD family from Southwestern China were reprogrammed into hiPSC lines by an episomal and non-integrating Sendai virus delivery method. The induced HD-hiPSC lines, SPPHi001-A and SPPHi002-A, were expanded and validated for their stem cell-like pluripotency, normal karyotyping, and capability of in vitro differentiation into three germ-layers.

Transfer Learning for Wireless Fingerprinting Localization Based on Optimal Transport.

Wireless fingerprinting localization (FL) systems identify locations by building radio fingerprint maps, aiming to provide satisfactory location solutions for the complex environment. However, the radio map is easy to change, and the cost of building a new one is high. One research focus is to transfer knowledge from the old radio maps to a new one.

[Study on the Imaging Quality Evaluation of Aspheric Intraocular Lenses].

The article is to study the objective evaluation method of the imaging quality of aspheric intraocular lens with different design concepts by establishing the model eye which is close to the actual corneal spherical aberration characteristics. Combined with the research data of corneal spherical aberration, the simulated cornea corresponding to Zernike c(4,0) coefficient 0.00 μm, 0.

Identification of a novel compound targeting the nuclear export of influenza A virus nucleoprotein.

Although antiviral drugs are available for the treatment of influenza infection, it is an urgent requirement to develop new antiviral drugs regarding the emergence of drug-resistant viruses. The nucleoprotein (NP) is conserved among all influenza A viruses (IAVs) and has no cellular equivalent. Therefore, NP is an ideal target for the development of new IAV inhibitors.

Design, Synthesis, and Biological Evaluation of Substituted Pyrimidines as Potential Phosphatidylinositol 3-Kinase (PI3K) Inhibitors.

Three series of substituted pyrimidines were designed and synthesized. All target compounds were screened for kinase inhibitory activities against PI3Kα, and most IC50 values were found within the nanomolar range. Compounds 5d and 5p displayed comparable activities relative to the positive control 5a.

Synthesis of Pelorol and Its Analogs and Their Inhibitory Effects on Phosphatidylinositol 3-Kinase.

There are numerous biologically active substances with novel structures and unique physiological functions in marine organisms. These substances are important sources of new lead compounds. Pelorol is a natural product isolated from marine organisms that possesses a novel structure with high bioactivity.

Impact of Insulin Sensitizers on the Incidence of Dementia: A Meta-Analysis.

Background: Abundant evidence from epidemiological and clinical studies has proven that diabetes mellitus (DM) is correlated with an increased incidence of dementia and Alzheimer's disease (AD). Insulin resistance is considered to play an important role in the associations between DM and dementia. However, whether insulin sensitizer drugs are effective in preventing dementia still remains unclear.

Dynamic expression changes of Bcl-2, Caspase-3 and Hsp70 in middle cerebral artery occlusion rats.

Background: This study aimed to study the dynamic changes of B cell lymphoma/leukaemia 2 (Bcl-2), caspase-3 and heat shock response protein 70 (Hsp70) in blood serum following acute middle cerebral artery occlusion (MCAO) in rats.

Methods: Occlusion of the cerebral artery was accomplished via the intraluminal filament, followed by the TTC staining evaluation and neurological deficit score. Meanwhile, the blood serum was extracted at 0.

Regularized frequency-stabilizing method for single closed-fringe interferogram demodulation.

We present a simple and fast regularized frequency-stabilizing method for single open- or closed-fringe interferogram demodulation. The proposed method recovers the phase maps of interferograms by establishing a cost function, according to prior knowledge. Because only the phase field to be estimated is employed in the cost function, the optimization process is fast.

Demodulation of a single complex fringe interferogram with a path-independent regularized phase-tracking technique.

The two-dimensional regularized phase-tracking (RPT) technique is one of the most powerful approaches to demodulate a single interferogram with either open or closed fringes. However, it often fails in the cases of complex interferograms and needs well-defined scanning strategies. An improved algorithm based on the RPT is presented in this paper.

Practical methods for retrace error correction in nonnull aspheric testing.

Nonnull test is often adopted for aspheric testing. But due to its violation of null condition, the testing rays will follow different paths from the reference and aberrations from the interferometer will not cancel out, leading to widely difference between the obtained surface figure and that of the real, which is called the Retrace-error accordingly. In this paper, retrace error of nonnull aspheric testing is analyzed in detail with conclusions that retrace error has much to do with the aperture, F number and surface shape error of the aspheric under test.