Study on promoting regeneration of zebrafish skull by phycocyanin characterized by in vivo optical coherence tomography.

In this study, the efficacy of phycocyanin in bone defect repairing was tested on a zebrafish skull defect model, and the evaluating process was monitored in vivo using optical coherence tomography (OCT). Thirty zebrafish were randomly divided into three groups, which were immersed in water and phycocyanin solution (50 and 100 mg/L) after skull defect creating. All zebrafish were examined by OCT immediately after craniotomy, and on the 10th and 20th days of phycocyanin treatment.

Triptolide laden reduced graphene oxide transdermal hydrogel to manage knee arthritis: and studies.

Triptolide (extract of herb ) is widely used in rheumatoid arthritis due to its potent immunosuppressant effect. The marketed oral (tablet dosage forms) and parenteral injections have short duration of action (half-life = 38 min) and not limited to multiorgan toxicity, which restrict the use of triptolide in clinical practice. In this study, a triptolide-loaded Pluronic® F68-reduced graphene oxide transdermal (non-invasive) hydrogel was developed to achieve sustained release of triptolide.

An azobenzene-based heteromeric prodrug for hypoxia-activated chemotherapy by regulating subcellular localization.

An azobenzene-based heteromeric prodrug (hNDP) was prepared for targeted chemotherapy against hypoxic tumor. hNDP could divert the parent drug from nucleus to cytoplasm with lower toxicity, while the azoreduction of hNDP in hypoxia would activate the drug with a robust anti-tumor effect by initiating the apoptosis-related biochemical cascades.

A novel combination of computer-assisted reduction technique and three dimensional printed patient-specific external fixator for treatment of tibial fractures.

Purpose: Good reduction and appropriate fixation are critical for long bone fractures, however, neither has been addressed satisfactorily. Robotic and navigation techniques can help improve the reduction accuracy. However, their clinical applications are limited by high cost and complexity in operation.

Modulation of β-adrenergic receptor in rat lung after gamma irradiation.

Objectives: To study the effect of γ irradiation on β-adrenergic receptors of the lung.

Materials And Methods: Healthy Sprague-Dawley rats were used as an animal model. Cell membrane proteins of lung tissue were harvested after the whole lung received 20 Gy of 60Co γ irradiation.

In vivo mouse ^{99m}Tc SPECT scans with bioluminescence imaging validation.

The aim of this in vivo study was to evaluate the feasibility of ^{99m}Tc-labeled cartilage link protein (CLP) probe for the single-photon emission computed tomography (SPECT) of lung cancer. Xenograft mouse model were established from a luciferase expressing cell line derived from a human lung cancer. Bioluminescence imaging (BLI) was carried out prior to ^{99m}Tc-CLP and ^{99m}Tc-methoxyisobutyl isonitrile (MIBI) SPECT scans.

[Feasibility of cartilage link protein of hyaluronic acid for defining radiotherapeutic target volume in a mouse model of lung tumor].

Objective: To investigate the feasibility of using cartilage link protein of hyaluronic acid (HA-CLP) for defining the tumor boundary in a mouse model of lung carcinoma.

Methods: Lung carcinoma was induced in KM mice by chemical carcinogenesis. HA-CLP separated from bovine cartilage and purified by affinity chromatography was labeled with (125)I for autoradiography.