New insights into crosstalk between Nrf2 pathway and ferroptosis in lung disease.

Ferroptosis is a distinctive process of cellular demise that is linked to amino acid metabolism, lipid oxidation, and iron oxidation. The ferroptosis cascade genes, which are closely associated with the onset of lung diseases, are among the regulatory targets of nuclear factor erythroid 2-related factor 2 (Nrf2). Although the regulation of ferroptosis is mostly mediated by Nrf2, the precise roles and underlying regulatory mechanisms of ferroptosis and Nrf2 in lung illness remain unclear.

Decursin protects against DSS-induced experimental colitis in mice by inhibiting the cGAS-STING signaling pathway.

While studies have shown that Angelica gigas Nakai (A. gigas) can alleviate ulcerative colitis in mice, the therapeutic role of its main active ingredient, decursin, is uncertain. Therefore, we aimed to investigate the protective effect and mechanism of decursin against inflammatory bowel disease (IBD) in vivo using mice.

Investigation of SrBO:Tm luminescence for temperature imaging with high sensitivity based on time-resolved luminescence.

In recent years, with the growing demand for non-contact and real-time optical temperature measurements, it has become imperative to develop new luminescent thermometry materials as well as novel temperature detection schemes with higher sensitivity. In this work, a series of SrBO:Tm ( = 0.001-0.

Research progress of cGAS-STING signaling pathway in intestinal diseases.

The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) signal has drawn much consideration due to its sensitivity to DNA in innate immune mechanisms. Activation of the cGAS-STIN signaling pathway induces the production of interferon and inflammatory cytokines, resulting in immune responses, or inflammatory diseases. The intestinal tract is a vital organ for the body's nutrition absorption, recent studies have had various points of view on the job of cGAS-STING pathway in various intestinal sicknesses.

Thermal imaging study of Sm doped SrBO based on time-resolved technology.

Thermal imaging materials with high sensitivity and the ability to reflect real-time temperature play an important role in research areas such as biotechnology and electronic engineering. However, the temperature sensitivity and temporal resolution of the current materials are not suitable for the complicated detection situation. In this paper, we introduce a thermal imaging material - SrBO:5%Sm - with high temperature sensitivity.

Angelica acutiloba Kitagawa flower induces A549 cell pyroptosis via the NF-κB/NLRP3 pathway for anti-lung cancer effects.

Angelica acutiloba Kitagawa, a traditional medicinal herb of the Umbelliferae family, has been demonstrated to have anticancer activity. In this study, we investigated the anti-lung cancer effects of two compounds extracted from A. acutiloba flowers: kaempferol-3-O-α-L-(4″-E-p-coumaroyl)-rhamnoside (KAE) and platanoside (PLA).

Investigation of the luminescence properties and energy transfer mechanisms in GdTaO:Bi,Eu phosphors for their potential application in full-spectrum WLEDs.

In recent years, there has been increasing effort devoted to the development of single-phase white phosphors due to drawbacks such as severe reabsorption and color deviation in traditional white light-emitting diodes (WLEDs). A new feasible strategy has emerged for achieving white light emission through the Bi-Eu energy transfer in suitable single-phase phosphors. Therefore, a series of GdTaO:Bi and GdTaO:0.

Role of mitochondrial stress and the NLRP3 inflammasome in lung diseases.

Background: As an organelle essential for intracellular energy supply, mitochondria are involved in intracellular metabolism and inflammation, and cell death. The interaction of mitochondria with the NLRP3 inflammasome in the development of lung diseases has been extensively studied. However, the exact mechanism by which mitochondria mediate the activation of the NLRP3 inflammasome and trigger lung disease is still unclear.

Ionizable drug delivery systems for efficient and selective gene therapy.

Gene therapy has shown great potential to treat various diseases by repairing the abnormal gene function. However, a great challenge in bringing the nucleic acid formulations to the market is the safe and effective delivery to the specific tissues and cells. To be excited, the development of ionizable drug delivery systems (IDDSs) has promoted a great breakthrough as evidenced by the approval of the BNT162b2 vaccine for prevention of coronavirus disease 2019 (COVID-19) in 2021.

Enhanced luminescence and tunable color in [Eu, Si]/Mn doped KBaCa(PO) based on charge compensation and energy transfer.

Recently, using the Eu2+ → Mn2+ energy transfer strategy to explore new single-phase phosphors suitable for the near-ultraviolet (n-UV) region has become one of the major strategies in solid-state lighting applications. Therefore, a novel color-tunable K2BaCa(PO4)2 (KBCPO):[Eu2+,Si4+],Mn2+ phosphor was developed because of the preeminent thermal stability of luminescence of Eu2+-activated KBCPO. In this study, we first designed a [Eu2+, Si4+] → [K+, P5+] charge compensation strategy to optimize the luminescence properties of Eu2+ in the KBCPO matrix.

Transparent and flexible resins functionalized by lanthanide-based upconversion nanocrystals.

Functional resins with optical adjustment capability own great potential in multiple application scenarios. To this end, we functionalize resins with upconversion nanocrystals (UCNCs), namely an UCNC-Au composite structure, to endow them with the unique ability of converting near-infrared (NIR) radiation into visible-light emission. Such UCNC-functionalized resins with high transparency and flexibility are expected to accelerate the development in the comprehensive utilization of NIR during practical applications.

A study on temperature sensing performance based on the luminescence of Eu and Er co-doped YNbO.

Eu3+ and Er3+ co-doped YNbO4 powder phosphors were synthesized by a traditional high-temperature solid-state reaction method. A laser of 487.6 nm wavelength was selected to be the excitation source which can pump Eu3+ ions from its thermally populated low-lying 7F2 ground state to the excited state 5D2 and lift the Er3+ ions from their 4I15/2 to 4F7/2 states.

Double perovskite ALaNbO:Mn,Eu (A = Ba, Ca) phosphors: potential applications in optical temperature sensing.

Recently, much attention has been paid to Mn-doped phosphors due to their strong deep-red emissions which are in demand in white light-emitting diodes. However, a key challenge for the commercialization of Mn-doped phosphors is their low thermal stability caused by the thermal quenching of Mn luminescence. Herein, a strategy of optical temperature sensing has been developed by specifically utilizing thermal quenching to explore the potential applications of Mn-doped phosphors in optical temperature sensing.

Temperature-dependent persistent luminescence of SrAlO:Eu, Dy, Tb: a strategy of optical thermometry avoiding real-time excitation.

A new strategy of optical thermometry is realized by long persistent luminescence phosphor SrAlO:Eu, Dy, Tb (SAEDT). Under different temperatures, SAEDT shows bright afterglow emissions after cessation of the UV excitation. The afterglow color of the SAEDT sample is blue at 60 K and gradually changed into green at 240 K.

Highly uniform and monodisperse β-NaYF : Sm nanoparticles for a nanoscale optical thermometer.

Monodisperse β-NaYF:1%Sm nanoparticles were fabricated successfully via the thermal decomposition technique. Strong temperature dependence of the Sm emission was observed when its thermally populated state H6 was directly excited to the G4 level. This strategy not only can eliminate laser heating and background Stokes-type scattering noise but also has a high quantum yield as a result of one-photon excitation process.

Luminescence properties and the thermal quenching mechanism of Mn doped ZnGeO long persistent phosphors.

Cation doped ZnGeO materials have been intensively explored owing to their excellent performance in photocatalysts, optoelectronic devices and white light-emitting diodes. However, the luminescence process and thermal quenching arising during the optical excitation of these materials are yet to be clarified. The pure and 2% Mn doped ZnGeO phosphors were prepared via the high temperature solid state reaction.

Investigation on the site occupation of rare-earth ions in CaInO with the fluorescence probe of Eu.

Rare-earth doped CaInO phosphors have been widely investigated due to their excellent luminescent property, but the site occupation of rare-earth ions in CaInO is not very clear and needs to be clarified. Using Eu as a fluorescence probe, such a clarification has been made in this work. 1% and 2% Eu doped CaInO powder samples have been prepared by the sol-gel method.

Temperature Sensing Using Thermal Population of Low-Lying Energy Levels with (SmGd)VO.

A temperature sensing scheme is proposed that is based on the dramatic temperature dependence of the photoluminescence when Sm dopants are excited from thermally populated H levels, rather than the ground level H, to the G luminescent level. The scheme has the advantage of eliminating laser heating and background Stokes-type scattering noise. Experimental realization was carried out on a (SmGd)VO sample by detecting the intensities at 550-580 nm using excitation wavelengths of 601.

Real-time micro-scale temperature imaging at low cost based on fluorescent intensity ratio.

Real-time temperature imaging with high spatial resolution has been a challenging task but also one with wide potential applications. To achieve this task, temperature sensor is critical. Fluorescent materials stand out to be promising candidates due to their quick response and strong temperature dependence.

Investigation of SrBO:Sm as a Multimode Temperature Sensor with High Sensitivity.

Sm-doped SrBO was synthesized for high-sensitivity thermometry. A high thermal-sensitive fluorescence intensity ratio and fluorescence lifetime were achieved in a wide temperature range. At 500 K, the relative sensitivity of the temperature sensing was 2.

Nonlinear Composition-Dependent Optical Spectroscopy of Ba2xSr2-2xV2O7.

In general, adjusting the composition of a fluorescent material is an effective way to tune its luminescent properties such as peak energy and bandwidth. In most solid-solutions, the emission peak shifts linearly with the materials' composition, which is referred to as Vegard's Law. However, we found extraordinary variations in our samples Ba2xSr2-2xV2O7, that is, both the excitation and emission peaks show nonlinear dependence on the composition x, and the same is true for the spectral bandwidths.

Local Environment Study of Eu3+ Doped KGd2F7 by Site-Selective Spectroscopy.

The site-selective spectra and decay curves at 20 K of Eu3+ ions doped KGd2F7 were measured to study the local environment of the Eu3+ sites. The experimental results show that Eu3+ ions occupy three types of sites in the KGd2F7 host. And Eu3+ ions in different types of sites exhibit quite distinct emission spectra and have remarkably different 5D0 level decay lifetimes.

Temperature sensor based on ladder-level assisted thermal coupling and thermal-enhanced luminescence in NaYF4: Nd³⁺.

NaYF4: Nd³⁺ microprisms were synthesized by a hydrothermal method. The bands of near-infrared (NIR) luminescence originating from the 4F3/2, 4F5/2 and 4F7/2 levels of Nd³⁺ ions in NaYF4: Nd³⁺ microcrystals were measured under 574.8 nm excitation at various temperatures from 323 to 673 K.

Strategy for thermometry via Tm³⁺-doped NaYF₄ core-shell nanoparticles.

Optical thermometers usually make use of the fluorescence intensity ratio of two thermally coupled energy levels, with the relative sensitivity constrained by the limited energy gap. Here we develop a strategy by using the upconversion (UC) emissions originating from two multiplets with opposite temperature dependences to achieve higher relative temperature sensitivity. We show that the intensity ratio of the two UC emissions, ³F(2,3) and ¹G₄, of Tm³⁺ in β-NaYF₄:20%Yb³⁺, 0.

Synthesis and luminescence properties of NaSrPO4:Eu2+, Tb3+, Mn2+ for WLED.

In order to obtain a single-host-white-light phosphor used for near ultraviolet (NUV) light emitting diodes (LEDs), the NaSrPO4:Eu2+, Tb3+, Mn2+ powder samples were synthesized via a high temperature solid-state reaction. XRD investigation shows a single phase. Energy transfer processes is discussed by analyzing the photoluminescence (PL) and photoluminescence excitation (PLE) spectra.