Relationship between the length of macular Bruch's membrane on fundus photograph and myopia occurrence in pre-myopia children aged 3-6 years: A 3-year longitudinal study.

Purpose: To evaluate the occurrence and influencing factors of myopia occurrence in pre-myopia children aged 3-6 years.

Methods: This study included 204 pre-myopia (-0.50D View Article and Find Full Text PDF

Temporal vascular arcade angle in fundus image was associated with the rate of spherical equivalent refractive error and axial length changes in myopia children with young school age.

Purpose: To evaluate temporal vascular arcade angle and its influencing factors in myopic children.

Methods: It was a retrospective study, we reviewed the records of 119 patients aged 6-10 years with myopia (spherical equivalent refractive error (SER) ≤ -0.05D) in the third year of follow-up in Beijing Hyperopia Reserve Research.

Tessellated fundus occurs earlier than myopia in children aged 3-6 years.

Background/objectives: Tessellated fundus can exist in normal healthy eyes. This study aims to evaluate the occurrence and influencing factors of tessellated fundus in preschool children aged 3-6 years.

Subjects/methods: This kindergarten-based cross-sectional study included 1716 children with an age range of 3-6 years.

Two cases of Duane retraction syndrome with abnormal orbital structures.

Duane retraction syndrome (DRS) is a rare congenital nonprogressive restrictive strabismus. The absence/hypoplasia of the abducens nerve and the aberrant innervation of the lateral rectus muscle by the oculomotor nerve have been hypothesized as causes of DRS, although the phenomenon of globe retraction can also occur in the setting of mechanical factors, such as congenital abnormal orbital structures or orbital trauma. We present the cases of 2 DRS patients with absent abducens nerve and abnormal muscular bands connecting the superior rectus and inferior rectus muscles on the temporal side of the optic nerve.

The Impact of Parental Myopia and High Myopia on the Hyperopia Reserve of Preschool Children.

Introduction: The aim of this study was to explore the association between parental myopia and high myopia with children's refraction and ocular biometry in large-scale Chinese preschool children from the Beijing Hyperopia Reserve Study.

Subjects/methods: This cross-sectional kindergarten-based study enrolled children aged 3-6 years. Cycloplegic refraction, axial length (AL), and corneal radius (CR) were measured for all children.

Two novel CHN1 variants identified in Duane retraction syndrome pedigrees disrupt development of ocular motor nerves in zebrafish.

Duane retraction syndrome (DRS) is a rare congenital eye movement disorder causing by the dysplasia of abducens nerve, and has highly variable phenotype. MRI can reveal the endophenotype of DRS. Most DRS cases are sporadical and isolated, while some are familial or accompanied by other ocular disorders and systemic congenital abnormalities.

A novel missense variant expands the phenotype and genotype of PAX6-associated foveal hypoplasia accompanied by various manifestations of anterior segment dysgenesis.

Background: According to previous reports, PAX6-associated foveal hypoplasia (FH) could usually be accompanied by various anterior segment anomalies including variable iris changes. This study aims to exhibit unusual phenotypes of a novel missense variant of PAX6 from a Chinese pedigree.

Methods: Ophthalmic examinations including slit-lamp biomicroscopy, gonioscopy, ophthalmic ultrasound, ultrasonic biomicroscopy, optical coherence tomography, wide-field fundus imaging, and visual field test were performed to evaluate the clinical manifestations.

Clinical and genetic characteristics of Chinese patients with congenital cranial dysinnervation disorders.

Background: Congenital cranial dysinnervation disorders (CCDDs) are a group of diseases with high clinical and genetic heterogeneity. Clinical examinations combined with Magnetic resonance imaging (MRI) and whole exome sequencing (WES) were performed to reveal the phenotypic and genotypic characteristics in a cohort of Chinese CCDDs patients.

Results: A total of 122 CCDDs patients from 96 families were enrolled.

Analysis of Drug Clinical Trials for Eye Diseases in China.

We systematically retrospected and analyzed the general characteristics of ophthalmic drug clinical trials (CTs) registered in China from January 2014 to December 2021. Data were retrieved from the Drug Trial Registration and Information Publication Platform and then standardized and statistically classified using bibliometric analysis. We identified 201 drug CTs for eye diseases, including 24 international multicenter trials.

Immobilization and phytoavailability of antimony (Sb) in contaminated agricultural soils amended with composted manure.

A pot experiment was conducted to assess the Sb phytoavailability and its accumulation in the wheat before and after remediation, using the composted manure of poultry and sheep, and a chemical amendment (limestone). The present study evaluates the effects of amendments on Sb bioavailability in different soils and investigates the relationship between bioaccumulated Sb and its availability in spiked soils using two different single extraction methods. Furthermore, a sequential extraction procedure was used to measure different fractions of Sb in soil, in order to assess the effect of remediation.

Simultaneous stabilization of Sb and As co-contaminated soil by FeMg modified biochar.

Currently, metalloid co-contamination, such as antimony and arsenic in soil, poses a serious threat to ecological stability and human health. Stabilization, a low-cost, effective, environmentally mild remediation strategy, shows enormous potential for mitigating environmental concerns. In this study, a novel FeMg modified porous biochar with different Fe/Mg proportions was prepared using the co-precipitation method to investigate the stabilizing efficiency in aqueous solutions and real soils.

Deep insight into the Sb(III) and Sb(V) removal mechanism by Fe-Cu-chitosan material.

Currently, alleviating antimony (Sb) contamination in aqueous solutions is crucial for restoring and recovering ecological and environmental health. Due to its toxicity, bioaccumulation and mobile characteristics, developing an efficient technique for antimony decontamination is imperative. Herein, we prepared a Fe-Cu-chitosan (FCC) composite by a one-step coprecipitation method, in which nanoscale Fe/Cu acts as the active sites and the whole structure is exhibited as porous microscale particles.

Effective methods of diabetic retinopathy detection based on deep convolutional neural networks.

Purpose: Diabetic retinopathy (DR) has become the leading cause of blindness worldwide. In clinical practice, the detection of DR often takes a lot of time and effort for ophthalmologist. It is necessary to develop an automatic assistant diagnosis method based on medical image analysis techniques.

Facile co-removal of As(V) and Sb(V) from aqueous solution using Fe-Cu binary oxides: Structural modification and self-driven force field of copper oxides.

Currently, the environmental and ecological damage caused by As(V) and Sb(V) co-contamination has attracted widespread attention worldwide. Due to the similar intrinsic structure configuration and electrostatic repulsion of As(V) and Sb(V), the long-standing issue of their low co-removal capacity remains unresolved. In this study, novel Fe-Cu (FC) binary materials with varied Fe/Cu proportions were synthesized via a simple co-precipitation method to co-eliminate aquatic As(V) and Sb(V).

Outcomes of secondary sulcus intraocular lens implantation in unilateral anterior persistent fetal vasculature.

Aim: To evaluate the surgical results of sulcus intraocular lens (IOL) implantation in children with unilateral anterior persistent fetal vasculature (PFV) underwent primary vitrectomy combined with lensectomy and preservation of the peripheral anterior capsule.

Methods: Twenty-two eyes of 22 children with unilateral anterior PFV who underwent sulcus secondary IOL implantation were analyzed. Main outcome measures were preoperative and postoperative visual acuity, and complications both intraoperatively and postoperatively.

Outcomes of small gauge pars plicata vitrectomy for patients with persistent fetal vasculature: a report of 105 cases.

Aim: To evaluate the surgical outcomes in eyes with persistent fetal vasculatures (PFV) managed by small gauge pars plicata vitrectomy.

Methods: Consecutive patients with PFV treated by small gauge pars plicata vitrectomy at Beijing Tongren Eye Center between January 2010 and January 2013 were retrospectively reviewed.

Results: A total of 118 eyes of 105 patients with PFV were included and undergone small gauge pars plicata vitrectomy, of which 84 (71.

[Brown syndrome: clinical and radiological correlation].

Objective: Brown syndrome is characterized by limitation of elevation in adduction, with complex mechanisms involving muscle, tendon, and trochlea. Here, we investigated mechanisms of Brown syndrome by magnetic resonance (MR) imaging.

Methods: It was a retrospective case series study.

Brain Abnormalities in Congenital Fibrosis of the Extraocular Muscles Type 1: A Multimodal MRI Imaging Study.

Purpose: To explore the possible brain structural and functional alterations in congenital fibrosis of extraocular muscles type 1 (CFEOM1) patients using multimodal MRI imaging.

Methods: T1-weighted, diffusion tensor images and functional MRI data were obtained from 9 KIF21A positive patients and 19 age- and gender-matched healthy controls. Voxel based morphometry and tract based spatial statistics were applied to the T1-weighted and diffusion tensor images, respectively.

Strabismus surgery distribution during 10-year period in a tertiary hospital.

Background: There is no large population-based study of the distribution and changing trend of strabismus surgeries in China. This study aimed to investigate the distribution and the changing trend of strabismus surgery in a tertiary hospital of China.

Methods: A retrospective study of all the strabismus surgeries performed in Beijing Tongren Eye Center from 2003 to 2012 was carried out.

Magnetic resonance imaging findings in sporadic Möbius syndrome.

Background: Although neuroradiological findings of Möbius syndrome have been reported as a result of brain and brainstem abnormalities, magnetic resonance imaging (MRI) now permits the direct imaging of the cranial nerve (CN) and branches in the orbits. This study presents the MRI findings in patients with sporadic Möbius syndrome.

Methods: Prospectively, CNs were imaged in the cistern using head coils and three dimensional fast imaging employing steady-state acquisition (3D-FIESTA), yielding a 0.

Regional specificity of sex effects on subcortical volumes across the lifespan in healthy aging.

When conceptualizing age-specific onsets and sex-specific characteristics of neuropsychiatric diseases in a neurobiological context, it may be crucially important to consider differential trajectories of aging. Here, we investigated effects of age, sex, and their interactions on absolute and relative volumes of subcortical structures with known involvement in psychiatric disorders, including the basal ganglia, thalamus, hippocampus, and amygdala. Structural MRI data of 76 healthy subjects (38 males, 19-70 years) from the ICBM database were analyzed.

Vertical deviation and A pattern of type III Duane retraction syndrome.

Background: Researches in ocular electromyography (EMG) and Magnetic resonance imaging (MRI) of patients with Duane retraction syndrome (DRS) suggest that there may be additional abnormalities such as paradoxical innervation between horizontal rectus muscles and vertical rectus muscles, hypoplasia of vertical rectus muscle and that oblique muscles may also contribute to the heterogeneity of the clinical manifestation of DRS. This paper reports the results of superior rectus recession for vertical deviation and A pattern in DRS Type III and discusses the pathogenesis of the disease.

Methods: Superior and lateral rectus recession were performed in 5 cases of Huber type III DRS to treat vertical deviation and A pattern strabismus.

[Vertical retraction syndrome caused by anomalous orbital structures].

Objective: To described the clinical feature and MRI imaging of six children with vertical retraction syndrome.

Methods: Six children with unilateral vertical retraction syndrome between 15 months and 8 years of age, mean age was (5.01 ± 1.

Magnetic resonance imaging of unilateral vertical retraction syndrome with atypical strabismus.

We report two patients with unilateral vertical retraction syndrome. Magnetic resonance imaging (MRI) of the orbits of the two cases showed similar size and location of the orbital structure, but with dramatically different strabismus type. MRI sagittal reconstruction of the orbits suggested that abnormal muscle tissue arised from the inferior rectus, which might be associated with retraction and narrowing of the palpebral fissure and atypical strabismus as well.