Publications by authors named "Yonghong Hu"

Research on the waterlogging tolerance mechanisms of helps us to further understand these mechanisms in the root system and enhance its root bark and oil yields in southern China. In this study, root morphological identification, the statistics of nine physiological and biochemical indicators, and a comparative transcriptome analysis were used to investigate the waterlogging tolerance mechanism in this plant. As flooding continued, the roots' vigor dramatically declined from 6 to 168 h of waterlogging, the root number was extremely reduced by up to 95%, and the number of roots was not restored after 96 h of recovery.

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, a plant of substantial economic significance, continues to face constraints in achieving large-scale propagation. In vitro propagation offers a promising avenue for the production of disease-free plants and the genetic transformation of peonies to instill novel traits. However, significant challenges persist in tissue culture, particularly with regards to the reproduction coefficient of shoots and the rooting process.

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  • * The review covers seven key areas of ultrasonic application: curing, tenderization, emulsification, freezing, thawing, sterilization, and flavor enhancement, with examples and explanations of mechanisms.
  • * The cavitation effect caused by ultrasound is highlighted as a crucial factor that boosts processing efficiency and improves the quality of meat products.
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In this study, the inclusion complex was prepared with butyl hydroxyanisole (BHA) as the functional substance and 2-hydroxypropyl beta-cyclodextrin (HP-β-CD) as the main molecule by ultrasound mediation. The inclusion complex was mixed with polycaprolactone (PCL)/polylactic acid (PLA), and nanofiber films loaded with different concentrations of BHA/HP-β-CD inclusion complex were prepared by electrospinning for fruit preservation. The scanning electron microscopy and infrared spectroscopy characterization results showed that HP-β-CD successfully embedded BHA in the cavity.

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Traditional beef jerky contains a high content of sodium salt while the reduction of sodium usage impairs the flavor of final product. Regarding above issues, this research innovatively applied ultrasound-assisted salts (NaCl and KCl) recombination in the pickling stage of low-sodium beef jerky, and further compared the flavor differences caused by ultrasound by sensory evaluation, E-nose and GC-IMS. Besides, the changes of physicochemical qualities were explored including salts content, color and shear force.

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Background: The potential role of probiotics in mitigating hyperlipidemia has garnered increasing evidence, yet the specific mechanisms warrant further investigation.

Objective: This study aimed to examine the alterations in short-chain fatty acids (SCFAs), a hypothesized lipid-lowering mechanism of probiotics, in animal models and to evaluate the lipid-lowering effects of probiotics on hyperlipidemic animal models through a meta-analysis of preclinical experiments. Methods: A comprehensive search of PubMed, Web of Science, EMBASE, Cochrane Library and Google Scholar up to June 2024 yielded nine studies that met the inclusion criteria (INPLASY registration number: No.

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In this study, we first successfully developed functionalized electrospun nanofibers (PCL/SP/ICs) loaded with Riboflavin (RF) for fruit preservation with inclusion complexes (RF/HP-β-CD, IC) formed by encapsulating RF with hydroxypropyl-β-cyclodextrin (HP-β-CD) as a core material and soy peptide-assisted polycaprolactones (PCL/SP) as an overwrap material. Compared to 1 wt% and 5 wt% IC, nanofibers implanted with 3 wt% IC had an acceptable water contact angle (87.40°), good thermal stability, and superior mechanical properties.

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Carotenoids are tetraterpene compounds acting as precursors to vitamin A, with functions that include protecting eyesight, enhancing immunity, promoting cell growth and differentiation, and providing antioxidative benefits. Lycopene, β-carotene, and astaxanthin are particularly critical for health and have diverse applications in food, health products, and medicine. However, natural carotenoids are encased within cell structures, necessitating mechanical methods to disrupt the cell wall for their extraction and purification-a process often influenced by environmental conditions.

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The stability-related asymmetry in roots, trunk, and crown is always found as a typical effect of biomechanical design under heterogeneous stimulus environment. However, it appears to be a conflict between the biomechanical principle and the source-sink distance of nutrient allocation strategies when the orientational asymmetry occurs. Adaptive growth strategies associated with biomass and nutrient allocation remain to be explored.

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  • The EC-CRT-001 phase II study showed that combining toripalimab with chemoradiotherapy can effectively treat patients with locally advanced esophageal squamous cell carcinoma (ESCC), with a follow-up showing 3-year overall survival (OS) and progression-free survival (PFS) rates of 44.8% and 35.7%, respectively.
  • Among the 42 patients, those who did not achieve a complete clinical response (CR) had significantly worse outcomes compared to those who did, indicating the importance of achieving CR in treatment success.
  • The study also found that patients experiencing immune-related adverse events (irAEs) had higher CR rates and better PFS, suggesting a potential link between these events
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  • Probiotics, prebiotics, and synbiotics are being researched as potential treatments for non-alcoholic fatty liver disease (NAFLD) and their impact on blood glucose levels is unclear.
  • A comprehensive analysis of 24 randomized controlled trials found that these supplements significantly lowered fasting blood glucose and fasting insulin levels, although they did not affect glycosylated hemoglobin levels.
  • The effectiveness of these supplements in reducing blood sugar levels appeared to decrease with higher body mass index (BMI) and was influenced by the number of probiotic strains used and the geographic location of the studies.
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In this work, the hydroxypropyl-β-cyclodextrin (HP-β-CD)/Epicatechin (EC) clathrate compounds were rapidly prepared based on an ultrasound-mediated method, and Polycaprolactone (PCL)/Locust bean gum (LBG) nanofibers loaded clathrate compounds were fabricated by electrostatic spinning (ELS) for fruit packaging. The results of infrared spectrum and crystal type analysis proved that clathrate compounds were successfully prepared. With the addition of clathrate compounds, the diameter of fibers increased from 553.

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  • A phase II trial showed that combining toripalimab (an anti-PD-1 antibody) with chemoradiotherapy is promising for treating locally advanced esophageal squamous cell carcinoma (ESCC), emphasizing the need for biomarkers to identify suitable patients.
  • In an analysis of 37 patients, high baseline PET/CT parameters, specifically SUV and TLG, correlated with lower treatment response and overall survival, while also indicating an immunosuppressive tumor microenvironment (TME).
  • The study suggests that monitoring these PET/CT metrics could help predict treatment outcomes and encourage further investigation into the relationship between metabolic activity and immune cell infiltration in ESCC.
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Corrections to the article based on comments published by Dr Acree, various models, including the modified Apelblat model, the λh model, the Jouyban-Acree model, the SUN model and the CNIBS/R-K model, recalculated, obtained new parameters and relative absolute percentage deviations.

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  • - A new electrochemiluminescence (ECL) biosensor was developed for detecting microRNA-21 (miRNA-21) using resonance energy transfer (RET) and surface plasmon coupling (SPC) for enhanced sensitivity.
  • - The biosensor involved coating a glassy carbon electrode with Cu-Zn-In-S quantum dots and modifying it with a hairpin DNA structure attached to gold nanoparticles that quenched ECL signals via RET.
  • - The sensor showed a 6.97-fold increase in ECL intensity through changing DNA structures and the use of Au dimers, allowing for precise detection of miRNA-21 in concentrations ranging from 10 fM to 10 pM, with applications in human serum sample
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In this study, we have for the first time constructed a ratiometric ECL biosensor for the ultrasensitive detection of microRNAs (miRNAs) using gold nanoparticles (Au NPs) to trigger both the low-potential emission from conjugated polymer poly(9,9-dioctylfluorene-2,7-diyl) dots (PFO Pdots) and the LSPR-ECL effect with sulfur-doped boron nitride quantum dots (S-BN QDs). PFO Pdots were first applied to the Au NPs-modified electrode, followed by covalent binding to capture the hairpin H1. Immediately thereafter, a small amount of miRNA-141 was able to generate a large amount of output DNA (OP) by traversing the target cycle.

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  • Whole-genome duplication (WGD) and chromosomal rearrangement play major roles in shaping the structure of genomes, particularly in polyploid plants like the London planetree (Platanaceae), which is an important street tree but lacks a reference genome.
  • Researchers created a high-quality, chromosome-level reference genome for London planetree, revealing it to be an ancient hexaploid with three similar subgenomes created from two WGD events, without sharing WGD features with other related groups.
  • The study found that London planetree has expanded flowering-time gene copies due to WGD, with gene functionality changes providing insights into its unique flowering-time regulation, contributing to a better understanding of evolutionary genetics in flowering plants.
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  • The aim of the study was to gather and synthesize existing evidence on the essential competencies required for nurses working in palliative care.
  • A scoping review was conducted using established frameworks and involved a thorough search of multiple academic databases for relevant studies published until December 2023.
  • Results from 26 studies revealed common competency assessment tools, with many nurses showing moderate levels of competency, and identified several factors influencing these competencies, highlighting the need for tailored strategies to enhance the skills of nurses in palliative care settings.
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Peroxynitrite is one of the important reactive oxygen species in the human body and is closely related to the physiological and pathological processes of many diseases. Therefore, the development of probes to detect peroxynitrite is important for diagnostic and pathologic studies of many diseases. In this work, a ratiometric probe was designed using benzopyran as the recognition site, and the sensitivity and selectivity of the probe were tuned by modification of substituents on benzopyran.

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Chitin oligosaccharides (CTOS) possess potential applications in food, medicine, and agriculture. However, lower mass transfer and catalytic efficiency are the main kinetic limitations for the production of CTOS from shrimp shell waste (SSW) and crystalline chitin. Chemical or physical methods are usually used for pretreatment to improve chitinase hydrolysis efficiency, but this is not eco-friendly and cost-effective.

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  • This study looks at how liver cells called hepatic progenitor cells (HPCs) react during liver damage and whether this helps the liver heal or makes it worse.
  • The researchers found that when liver damage happens, HPCs can get more active and develop into another type of cell called cholangiocytes, which is linked to worsening liver fibrosis (scarring).
  • They also discovered that a protein called Gli1 plays a big role in this process, and by reducing Gli1, they could decrease the damage and scarring in the liver.
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A multicolor electrochemiluminescence (ECL) biosensor based on a closed bipolar electrode (BPE) array was proposed for the rapid and intuitive analysis of three prostate cancer staging indicators. First, [Irpic-OMe], [Ir(ppy)(acac)], and [Ru(bpy)] were applied as blue, green, and red ECL emitters, respectively, whose mixed ECL emission colors covered the whole visible region by varying the applied voltages. Afterward, we designed a simple Mg-dependent DNAzyme (MNAzyme)-driven tripedal DNA walker (TD walker) to release three output DNAs.

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