Publications by authors named "Yongheng Sui"
Article Synopsis
- Dexmedetomidine (DEX) is a drug commonly used for sedation during liver surgery, but its effects on liver cell autophagy and regeneration were previously unclear.
- The study investigated how DEX impacts autophagic flux and liver regeneration in mice after a partial hepatectomy (PHx), using various methods to assess liver recovery and autophagy indicators.
- Results showed that DEX treatment before and after PHx sped up liver regeneration and improved autophagic flux, primarily by inhibiting GSK3β activity in an α2-adrenergic receptor-dependent way.
Aim: To investigate the effect of different dietary fatty acids on hepatic inflammasome activation.
Methods: Wild-type C57BL/6 mice were fed either a high-fat diet or polyunsaturated fatty acid (PUFA)-enriched diet. Primary hepatocytes were treated with either saturated fatty acids (SFAs) or PUFAs as well as combined with lipopolysaccharide (LPS).
Background: Dietary n-3 polyunsaturated fatty acids (PUFA) exert anti-inflammatory and immunoregulatory effects through down-regulating the innate and adoptive immune response. However, the effect of dietary n-3 PUFA on CD4+CD25+ regulatory T cells (Tregs) is unclear.
Aims: The current study was to examine the relationship between n-3 PUFA and Tregs as well as their immunoregulatory effect in immune-mediated liver injury.
Background: Dietary lipids play an important role in the progression of non-alcoholic fatty liver disease (NAFLD) through alternation of liver innate immune response.
Aims: The present study was to investigate the effect of lipid on Kupffer cells phenotype and function in vivo and in vitro. And further to investigate the impact of lipid on ability of Kupffer cell lipid antigen presentation to activate NKT cells.