Publications by authors named "Yonghao Lin"
Acta Pharm Sin B
August 2024
Article Synopsis
- - The study highlights an increased presence of mesenchymal homobox 1 (MEOX1) in patients with pulmonary fibrosis, identifying it as a key player in activating genes that contribute to the disease.
- - Researchers discovered Ailanthone (AIL), a natural compound, which can directly inhibit MEOX1 and stop the harmful processes in fibroblasts and endothelial cells triggered by TGF-1.
- - In experiments using an animal model, AIL was shown to significantly reduce fibrosis and improve lung function by blocking JUN's interaction with MEOX1, illustrating its potential as a targeted therapy for pulmonary fibrosis.
