Publications by authors named "Yonghao Guo"

Enterohemorrhagic (EHEC) O157:H7 and Enterotoxigenic (ETEC) are important foodborne pathogens, causing serious food poisoning outbreaks worldwide. Bacteriophages, as novel antibacterial agents, have been increasingly exploited to control foodborne pathogens. In this study, a novel broad-host range lytic phage vB_EcoM_SQ17 (SQ17), was isolated, characterized, and evaluated for its potential to control bacterial counts and in three different food matrices (milk, raw beef, and fresh lettuce).

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To evaluate the efficiency of a 20 μg hepatitis B vaccine(HepB) for disease prevention in two counties in Henan Province, China. A questionnaire was designed to examine the information of hepatitis B surface antigen (HBsAg) positive pregnant women, and their blood samples were collected to test for hepatitis B e antigen (HBeAg), hepatitis B e antibody, and hepatitis B virus (HBV) DNA. Three doses of 20 μg HepB and one dose of hepatitis B immune globulin(HBIG) were administered to newborns.

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Introduction: Pertussis is one of the top 10 diseases of children under 10 years of age, and the few vaccine-preventable diseases who is on a rise in China in recent years; however, the true burden of pertussis, including age-stratified incidence and risk factors of severe sequelae, are under-recognised. We aim to estimate the health burden of laboratory-confirmed pertussis by age groups, considering the setting of illness onset (ie, in community, outpatient and inpatient), in a Chinese population (~2.23 million in total) at two sites.

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This article develops a rapid performance evaluation approach for lower mobility hybrid robot, which provides guidance for manipulator evaluation, design, and optimization. First, a general position vector model of gravity center for the lower mobility hybrid robot in the whole workspace is constructed based on a general inverse kinematic model. A performance evaluation index based on gravity-center position is then proposed, where the coordinates pointing to the supporting direction are selected as the evaluation index of the robot performance.

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Objectives: To analyze the effects of one dose of live attenuated hepatitis A vaccine in a developing country.

Methods: The reported cases of hepatitis A virus (HAV) infection from 2005 to 2018 in Henan province, China, were analyzed. Data of vaccinated children were assessed on the childhood immunization information management system.

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Coastal organic pollution has become a serious problem, thus it is imperative to assess the potential effects on the marine environment. The microbes are generally the first responders to environmental perturbation, which may serve as biological indicators for pollution levels. In this study, we collected surface seawater samples from Sanmen Bay and adjacent Yushan Reserve.

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To understand the genotype and the mutation of amino acid (aa) in the major hydrophilic region (MHR) of hepatitis B virus(HBV). The serum samples were collected from the surveillance of HBV among population in Henan in 2012. The S gene of HBV was amplified and sequenced.

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Article Synopsis
  • The hepatitis B vaccine was introduced in Henan, China in 1992, and a survey in 2012 assessed its effectiveness on children born in the following 15 years.
  • A total of 13,207 children aged 1 to 14 were surveyed, showing low rates of hepatitis B surface antigen (0.8%) and core antibody (2.6%), with significant decreases in HBsAg prevalence since the vaccine's introduction.
  • Key risk factors for higher HBsAg positivity included having an infected family member, no vaccination history, being born in smaller hospitals or at home, being older (10-14 years), and living in rural areas.
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Objective: To describe the prevalence and risk factors of hepatitis C virus (HCV) occurred in Henan province, at the end of 2011.

Methods: Five villages round Maqiao township, including 5187 residents, were selected for the study. Five-milliliter-blood was drawn from every one of the interviewee.

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Article Synopsis
  • * Experiments showed that Aa-TrkA and Aa-TrkH restored growth in E. coli under low potassium conditions, and interestingly, Aa-TrkAH functioned without the common ATP-binding protein TrkE, suggesting a unique potassium transport mechanism in A. amylolytica.
  • * The study also found that this transporter operates optimally at alkaline pH levels (around 8.5) and highlighted specific
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Identification of differentially proteomic responses to external pHs would pave an access for understanding of survival mechanisms of bacteria living at extreme pH environment. We cultured Alkalimonas amylolytica N10 (N10), a novel alkaliphilic bacterium found in Lake Chahannor, in media with three different pHs and extracted the correspondent membrane and cytoplasm proteins for proteomic analysis through 2-DE. The differential 2-DE spots corresponding to the altered pHs were delivered to MALDI TOF/TOF MS for protein identification.

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