The Effect of Different Doses of Ciprofol in Patients with Painless Gastrointestinal Endoscopy.

Background: Ciprofol is currently used for painless gastrointestinal endoscopy and anesthesia induction. However, whether it is superior to propofol and its optimal dose remains unknown.

Methods: A total of 149 patients, 63 males and 86 females, aged 18-80 years, BMI 18-28 kg/m, ASA I-III, were divided randomly into four groups: propofol group (group P, n = 44), ciprofol 0.

Primary tracheal obstruction caused by adenoid cystic carcinoma during pregnancy: A case report.

The incidence of malignant tumors diagnosed during pregnancy is increasing, often ascribed to the recently recognized trend that many women are postponing childbirth. Although early diagnosis is optimal for both mothers and fetuses, the diagnosis of malignant tumors during pregnancy is often delayed until an advanced stage, because generalized symptoms of pregnancy and malignancy may overlap, such as shortness of breath, chest or abdominal discomfort. The study patient was 21 years old, and 31 weeks-pregnant when she was diagnosed with primary tracheal adenoid cystic carcinoma (ACC).

Ulinastatin promotes macrophage efferocytosis and ameliorates lung inflammation via the ERK5/Mer signaling pathway.

Acute lung injury (ALI) is a pneumonic response characterized by neutrophil infiltration. Macrophage efferocytosis is the process whereby macrophages remove apoptotic cells, and is required for ALI inflammation to subside. The glycoprotein ulinastatin (UTI) has an anti-inflammatory effect during the acute stages of ALI, but its effect on efferocytosis and the subinflammatory stage of ALI is unclear.

[Vitamin D analogues activate vitamin D receptor/glutathione peroxidase 4 pathway to improve ventilator-induced lung injury in mice].

Objective: To investigate the role of vitamin D analogue paricalcitol in activating vitamin D receptor/glutathione peroxidase 4 (VDR/GPX4) pathway in ventilator-induced lung injury (VILI).

Methods: Twenty-four male C57BL/6J mice were randomly divided into control group, high tidal volume (HVT) induced VILI model group (HVT group), paricalcitol control group (P group), and paricalcitol pretreatment group (P+HVT group), with 6 mice in each group. The mice were endotracheal intubated and ventilated at 40 mL/kg tidal volume to prepare VILI model, while those in the control group were intubated without ventilation.

Effect of dexmedetomidine on perioperative hemodynamics and organ protection in children with congenital heart disease: A randomized controlled trial.

Background: This study aimed to investigate the effects of dexmedetomidine (Dex) on hemodynamics and organ protection in congenital heart disease (CHD) children who underwent open-heart surgery under cryogenic cardiopulmonary bypass.

Methods: Ninety children were randomly allocated to group C (0.9% saline 0.

Perioperative dexmedetomidine and postoperative delirium in non-cardiac surgery: a meta-analysis.

Background: To compare the effects of perioperative dexmedetomidine with placebo (or other sedation) on the rate of postoperative delirium in adult patients who underwent non-cardiac surgeries.

Methods: A meta-analysis was performed on randomized, controlled trials. MEDLINE, the Cochrane Central Register of Controlled Trials, and Embase (to March 20, 2019) were searched for literature retrieval.