Ultrasensitive optical electric field sensor with temperature compensation for point-wise and quasi-distributed sensing.

A point-wise and quasi-distributed optical sensing technique with the Vernier effect is proposed and achieved by multiplexing Fabry-Perot interferometers (FPIs). The FPIs are fabricated by LiNbO (LN) crystals of varying lengths to enable simultaneous measurement of electric field (E-field) and temperature. Compared to the traditional bulk-type optical E-field sensors, this innovative sensor enables E-field measurement without being limited by half-wave voltage and effectively avoids the influence of natural birefringence.

Cisplatin resistance-related transcriptome and methylome integration identifies as a novel prognostic biomarker in small cell lung cancer.

Platinum-based chemo-resistance is the major issue for the treatment of small cell lung cancer (SCLC). The integrative analysis of multi-omics data is a reliable approach for discovering novel biomarkers associated with chemo-resistance. Here, multi-omics integrative analysis and Cox regression found that higher expression of was associated with poorer survival of SCLC patients who received chemotherapy.

The genetic causal association between hip or knee osteoarthritis and frailty: a two-sample Mendelian randomization analysis.

Introduction: Osteoarthritis of the hip or knee has been reported to be linked to an increased risk of frailty. However, a definitive conclusion about whether hip or knee osteoarthritis increases susceptibility to frailty remains elusive.

Material And Methods: The instrumental variables (IVs) used in this analysis were sourced from publicly available genome-wide association study (GWAS) datasets.

Unraveling the relationship between serum parathyroid hormone levels and trabecular bone score: a cross-sectional study.

The TBS is a new method for clinicians to assess the bone quality. It is directly related to the mechanical strength of bone and helps predict fracture risk. The present analysis aimed to investigate the associations between serum PTH levels and TBS by analyzing data from the National Health and Nutrition Examination Survey (NHANES).

Effect of Tranexamic Acid on Hidden Blood Loss in Percutaneous Endoscopic Transforaminal Lumbar Interbody Fusion: A Retrospective Study.

Purpose: Percutaneous endoscopic transforaminal lumbar interbody fusion (PE-TLIF) has become one of the most popular minimally invasive surgeries today. However, the issue of hidden blood loss (HBL) in this surgery has received little attention. This study aims to examine the HBL in PE-TLIF surgery and the effect of tranexamic acid (TXA) on blood loss.

CD3, CD8, IFN-γ, tumor and stroma inflammatory cells as prognostic indicators for surgically resected SCLC: evidences from a 10-year retrospective study and immunohistochemical analysis.

Current clinical guidelines limit surgical intervention to patients with cT1-2N0M0 small cell lung cancer (SCLC). Our objective was to reassess the role of surgery in SCLC management, and explore novel prognostic indicators for surgically resected SCLC. We reviewed all patients diagnosed with SCLC from January 2011 to April 2021 in our institution.

Diminished representational momentum for physical states in patients with depressive disorder.

The representational momentum for physical state changes refers to the fact that we remember objects as more changed in physical state than they actually were. It has been well documented that depressive disorder is associated with impairment of time perception. Thus, the present work was conducted with the aim to investigate the representational momentum for physical state changes in patients with depressive disorder, firstly.

A Controlled Clinical Study of Accelerated High-Dose Theta Burst Stimulation in Patients with Obsessive-Compulsive Disorder.

Background: Obsessive-compulsive disorder (OCD) is frequently treated using a combination of counseling, drugs, and, more recently various transcranial stimulation protocols, but all require several weeks to months for clinically significant improvement, so there is a need for treatments with faster onset. This study investigated whether an accelerated high-dose theta burst stimulation (ahTBS) protocol significantly improves the efficacy of OCD compared to traditional 1-Hz repetitive transcranial magnetic stimulation (rTMS) in the routine clinical setting.

Method: Forty-five patients with OCD were randomized into two groups and treated with ahTBS or 1-Hz rTMS for 5 days.

Process Optimization of Polishing Titanium Alloy Material with a Pulsating Air Jet.

Titanium alloy is a widely used metal material, which can be applied in fields such as healthcare, petroleum exploration, aerospace, etc. In this paper, a new method for polishing the titanium alloy by a pulsating air jet is proposed. Compared with traditional abrasive jet polishing, this method has the advantages of simple structure, low nozzle wear, and high polishing flexibility.

Intense electric field optical sensor based on Fabry-Perot interferometer utilizing LiNbO crystal.

A novel intense electric field optical sensor based on Fabry-Perot interferometer utilizing LiNbO crystal is proposed and demonstrated. Compared to the traditional bulk-type electric field optical sensors, this sensor unit requires only a LiNbO and two collimators, eliminating the need for quarter wave-plate and allowing for measurement of electric field without limitation by half wave voltage. The Vernier effect, generated by birefringence of LiNbO, is utilized to enhance the sensitivity of electric field measurement, which does not require additional reference cavity.

Enhanced toluene gas-sensing properties of MEMS sensor based on Pt-loaded SnOnanoparticles.

Rapid detection of low concentration toluene is highly desirable in environment monitoring, industrial processes, medical diagnosis, etc. In this study, we prepared Pt-loaded SnOmonodispersed nanoparticles through hydrothermal method and assembled a sensor based on micro-electro-mechanical system (MEMS) to detect toluene. Compared with the pure SnO, the 2.

Increased EEG gamma power under exposure to drug-related cues: a translational index for cue-elicited craving in METH-dependent individuals.

Background: This study explored the feasibility of using EEG gamma-band (30-49 Hz) power as an index of cue-elicited craving in METH-dependent individuals.

Methods: Twenty-nine participants dependent on methamphetamine (METH) and 30 healthy participants were instructed to experience a METH-related virtual reality (VR) social environment.

Results: Individuals with METH dependence showed significantly stronger self-reported craving and higher gamma power in a VR environment than healthy individuals.

Virtual-reality-based social cognition and interaction training for patients with schizophrenia: A preliminary efficacy study.

Background: Social cognition and interaction training (SCIT) is a psychosocial intervention program for patients with psychosis, designed to improve their social functioning by improving social cognition. Although the feasibility and efficacy of SCIT have been verified, patients with schizophrenia tend to suffer from motivational deficits and low treatment adherence. It has been suggested that using virtual reality (VR) technology might be effective in addressing these issues.

Altered EEG Microstates Dynamics During Cue-Induced Methamphetamine Craving in Virtual Reality Environments.

Background: Cue-induced craving is widely considered to be the most important risk factor for relapse during abstinence from methamphetamine (Meth). There is limited research regarding electroencephalography (EEG) microstates of Meth-dependent patients under exposure to drug-related cues. Our objective was to investigate whether EEG microstate temporal characteristics could capture neural correlates of cue-induced Meth craving in virtual reality (VR) environments.

Establishment and Verification of Prognostic Nomograms for Young Women With Breast Cancer Bone Metastasis.

Purpose: The prognosis of patients with metastatic breast cancer usually varies greatly among individuals. At present, the application of nomogram is very popular in metastatic tumors. The present study was conducted to identify independent survival predictors and construct nomograms among young women with breast cancer bone metastasis (BCBM).

Determination of Bridge Prestress Loss under Fatigue Load Based on PSO-BP Neural Network.

During the service period of a prestressed concrete bridge, as the number of cyclic loads increases, cumulative fatigue damage and prestress loss will occur inside the structure, which will affect the safety, durability, and service life of the structure. Based on this, this paper studies the loss of bridge prestress under fatigue load. First, the relationship between the prestress loss of the prestressed tendons and the residual deflection of the test beam is analyzed.

Identification and comparison of novel circular RNAs with associated co-expression and competing endogenous RNA networks in postmenopausal osteoporosis.

Background: Circular RNAs (circRNAs) are emerging as crucial regulators in various human diseases. So far, the expression profile and regulatory mechanism of circRNAs in postmenopausal osteoporosis (PMOP) are less studied and should be deciphered urgently. Herein, we aimed to reveal key circRNAs affecting PMOP and clarify their compounding regulatory actions.

Neural Stochastic Differential Equations with Neural Processes Family Members for Uncertainty Estimation in Deep Learning.

Existing neural stochastic differential equation models, such as SDE-Net, can quantify the uncertainties of deep neural networks (DNNs) from a dynamical system perspective. SDE-Net is either dominated by its drift net with in-distribution (ID) data to achieve good predictive accuracy, or dominated by its diffusion net with out-of-distribution (OOD) data to generate high diffusion for characterizing model uncertainty. However, it does not consider the general situation in a wider field, such as ID data with noise or high missing rates in practice.

Monitoring Strain Response of Epoxy Resin during Curing and Cooling Using an Embedded Strain Gauge.

The present work describes the monitoring system of the real-time strain response on the curing process of epoxy resin from the initial point of curing to the end, and the change in strain during temperature changes. A simple mould was designed to embed the strain gauge, thermometer, and quartz standard sample into the epoxy resin, so that the strain and the temperature were simultaneously measured and recorded. A cryogenic-grade epoxy resin was tested and the Differential Scanning Calorimetry (DSC) was used to analyse the curing process.

Highly Compressible, Thermally Conductive, yet Electrically Insulating Fluorinated Graphene Aerogel.

Carbon-based aerogels have drawn substantial attention for a wide scope of applications. However, the high intrinsic electrical conductivity limits their potential thermal management application in electronic packaging materials. Herein, a highly compressible, thermally conductive, yet electrically insulating fluorinated graphene aerogel (FGA) is developed through a hydrofluoric acid-assisted hydrothermal process.

The immediate mental health impacts of the COVID-19 pandemic among people with or without quarantine managements.

• High prevalence of mental health problems was found in people. • Quarantine was not related with the prevalence of mental health problems. • Impacts on daily life predicted mental health problems significantly.

Self-Assembled Boron Nitride Nanotube Reinforced Graphene Oxide Aerogels for Dielectric Nanocomposites with High Thermal Management Capability.

Thermally conductive polymeric composites are highly promising in current energy devices such as light-emitting diodes, integrated circuits, and solar cells to achieve appropriate thermal management. However, the introduction of traditional thermoconductive fillers into a polymer usually results in low thermal conductivity enhancement. Here, an ideal dielectric epoxy nanocomposite with ultrahigh thermal conductivity is successfully fabricated using three-dimensional interconnected boron nitride nanotube reinforced graphene oxide nanosheet (3D-BNNT-GONS) aerogels as fillers.