Publications by authors named "Yongfu Lou"
Article Synopsis
- Activation of endogenous neural stem cells (NSCs) can promote healing after spinal cord injuries, but methods to regulate these cells are limited.
- This study found that nicotinamide riboside enhances the growth of NSCs and helps them differentiate into neurons, leading to improved lower limb motor function after injury.
- The mechanism behind this involves the activation of the Wnt signaling pathway through the LGR5 gene, as blocking this pathway hinders the effects of nicotinamide riboside on NSC proliferation.
Spinal cord injury (SCI) is a devastating condition for which effective clinical treatment is currently lacking. During the acute phase of SCI, myriad pathological changes give rise to subsequent secondary injury. The results of our previous studies indicated that treating rats post-SCI with nafamostat mesilate (NM) protected the blood-spinal cord barrier (BSCB) and exerted an antiapoptotic effect.
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- The study examines age-based differences in traumatic spinal cord injury (TSCI) inpatients in China, noting that older patients had longer delays for surgery, a higher likelihood of incomplete injuries, and longer hospital stays compared to younger patients.
- Researchers analyzed medical records from 13,334 TSCI patients across 30 hospitals from 2013 to 2018, finding a significant increase in the number and proportion of elderly patients (≥85 years) during this period.
- Key findings revealed that younger patients were more likely to undergo crucial decompression surgery, while elderly patients had lower hospitalization costs, highlighting important disparities in treatment and care between age groups.
Article Synopsis
- Traumatic spinal cord injury (SCI) poses serious risks, including permanent disability and death, and China has the highest number of patients affected.
- This study analyzed data from 13,465 SCI patients across China from 2013 to 2018, focusing on their clinical features, treatment methods, and the economic impact of their injuries.
- Results showed that surgery rates were high, but timely interventions were scarce, with overall treatment costs decreasing, although daily costs remained stable, indicating a need for improved healthcare strategies.
N-Methyladenosine (m1A) is an abundant modification of transcripts, plays important roles in regulating mRNA structure and translation efficiency, and is dynamically regulated under stress. However, the characteristics and functions of mRNA m1A modification in primary neurons and oxygen glucose deprivation/reoxygenation (OGD/R) induced remain unclear. We first constructed a mouse cortical neuron OGD/R model and then used methylated RNA immunoprecipitation (MeRIP) and sequencing technology to demonstrate that m1A modification is abundant in neuron mRNAs and dynamically regulated during OGD/R induction.
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- This study is a retrospective epidemiological analysis focusing on the differences in traumatic spinal cord injury (TSCI) based on biological sex in China from 2013 to 2018.
- The study included data from 13,465 TSCI patients across 30 hospitals, revealing a decreasing male-to-female ratio and a faster rise in TSCI cases among females compared to males.
- Key findings showed that while higher-level falls affected more males, females had a higher occurrence of thoracolumbar injuries and less severe neurological damage, indicating the need for sex-specific prevention and treatment strategies.
Article Synopsis
- Cerebral ischaemia-reperfusion injury causes oxygen and glucose deprivation in neurons, a process not previously studied through epitranscriptomics, which examines RNA modifications like m6A.* -
- The study analyzed m6A modification profiles in normal and OGD/R-treated neurons using MeRIP-seq and bioinformatics, revealing crosstalk between m6A mRNA and circRNA.* -
- Findings indicate that specific m6A circRNA production patterns are influenced by the timing of OGD/R treatments, suggesting potential epigenetic mechanisms for understanding and treating related neurological diseases.*
Background: Increased folic acid has been found to be latently protective against gynecological infection, including several kinds of vaginosis. In this study, we laid emphasis on whether RBC (Red Blood Cell) folate was associated with the infectious ratio of Trichomonas vaginalis, a kind of anaerobic parasitic protozoan.
Methods: We set RBC folate as the exposure variable and Trichomonas vaginalis as the outcome variable.
Identification of Differentially Expressed Proteins in Rats with Early Subacute Spinal Cord Injury using an iTRAQ-based Quantitative Analysis.
Comb Chem High Throughput Screen
June 2023
Article Synopsis
- Injuries to the central nervous system, specifically spinal cord injuries, can have severe consequences on individuals and society, particularly during the early subacute phase where secondary damage occurs.
- The study analyzed protein expression in rats three days post-injury using methods like iTRAQ and identified 176 differentially expressed proteins, with a majority being up-regulated.
- Findings highlight key proteins and biological processes involved in the early subacute phase of spinal cord injury, suggesting new avenues for understanding and treating CNS injuries.
Background: Aging is an influential risk factor for progression of both degenerative and oncological diseases of the bone. Osteosarcoma, considered the most common primary mesenchymal tumor of the bone, is a worldwide disease with poor 5-year survival. This study investigated the role of aging-/senescence-induced genes (ASIGs) in contributing to osteosarcoma diagnosis, prognosis, and therapeutic agent prediction.
View Article and Find Full Text PDFObservational studies provided conflicting results on the association between iron status and the risk of lung cancer. The aim of our study was to investigate the effect of genetically determined iron status on lung cancer risk using a mendelian randomization (MR) approach. Single-nucleotide polymorphisms for iron status were selected from a genome-wide meta-analysis of 48,972 subjects.
View Article and Find Full Text PDFBackground: Ischemia-reperfusion injury (IRI) is an important pathophysiological condition that can cause cell injury and large-scale tissue injury in the nervous system. Previous studies have shown that epigenetic regulation may play a role in the pathogenesis of IRI.
Methods: In this study, we isolated mouse cortical neurons and constructed an oxygen-glucose deprivation/reoxygenation (OGD) model to explore the change in DNA methylation and its effect on the expression of corresponding genes.
Unlabelled: This study provides a national estimate of the incidence of hospitalizations and assesses the clinical features and outcomes during inpatient admission due to osteoporotic fractures diagnosed by ICD-10-CM/PCS among the elderly in the USA, using the US Nationwide Inpatient Sample, 2016-2018.
Purpose: To provide a national estimate of the incidence of hospitalizations and assess the clinical features and outcomes during inpatient admission due to osteoporotic fractures (OFs) among the elderly in the USA.
Methods: The study included all inpatients aged 65 years and older who participated in the US Nationwide Inpatient Sample (NIS).
Epigenetic modifications play an important role in central nervous system disorders. As a widespread posttranscriptional RNA modification, the role of the mC modification in cerebral ischemia-reperfusion injury (IRI) remains poorly defined. Here, we successfully constructed a neuronal oxygen-glucose deprivation/reoxygenation (OGD/R) model and obtained an overview of the transcriptome-wide mC profiles using RNA-BS-seq.
View Article and Find Full Text PDFBACKGROUND Spinal cord injury (SCI) is a devastating trauma of the central nervous system (CNS), with high levels of morbidity, disability, and mortality. One week after SCI may be a critical time for treatment. Changes in protein expression have crucial functions in nervous system diseases, although the effects of changes occurring 1 week after SCI on patient outcomes are unclear.
View Article and Find Full Text PDFThe present study aimed to explore the role of the PTEN/Akt/mTOR signaling pathway in the neurite outgrowth and apoptosis of cortical neurons. Cortical neurons were seeded on or adjacent to chondroitin sulfate proteoglycans. The length, number and crossing behavior of the neurites were calculated.
View Article and Find Full Text PDF[This corrects the article on p. 1895 in vol. 11, PMID: 30972213.
View Article and Find Full Text PDFThe fate of neural stem cells (NSCs) is decided by numerous growth factors. Among these factors, the well-known angiogenic factor angiopoietin-2 (Ang-2) has been revealed to participate in neurogenesis separate from its role in angiogenesis. However, the effect of Ang-2 on the fate determination of mouse embryonic NSCs and the underlying mechanism remain unclear.
View Article and Find Full Text PDFBackground: Spinal cord injury (SCI) is a disease associated with high disability and mortality rates. The transitional phase from subacute phase to intermediate phase may play a major role in the process of secondary injury. Changes in protein expression levels have been shown to play key roles in many central nervous system (CNS) diseases.
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