Establishment and validation of a dynamic nomogram to predict short-term prognosis and benefit of human immunoglobulin therapy in patients with novel bunyavirus sepsis in a population analysis study: a multicenter retrospective study.

Objective: This study aims to develop a dynamic nomogram model using machine learning to improve short-term prognosis prediction and identify patients who would benefit from intravenous immunoglobulin (IVIG) therapy.

Methods: A multicenter retrospective study was conducted on 396 patients diagnosed with SFTS. Univariate and multivariate Cox regression analyses identified significant predictors of mortality.

Effects of variable resistance training within complex training on strength and punch performance in elite amateur boxers.

Objectives: This study explored the effects of 6 weeks of variable resistance training (VRT) and constant resistance training (CRT) within complex training, on muscle strength and punch performance.

Methods: Twenty-four elite female boxers from the China National team were divided randomly between an experimental group (VRT) and a control group (CRT). Maximum strength of the upper and lower limbs, countermovement jump (CMJ) performance, and punch performance (single, 10s and 30s continuous) were assessed pre- and post- intervention.

Long non-coding RNA small nucleolar RNA host gene 8 (SNHG8) sponges miR-34b-5p to prevent sepsis-induced cardiac dysfunction and inflammation and serves as a diagnostic biomarker.

Introduction: The study aimed to evaluate, for the first time, the diagnostic value of long non-coding RNA (lncRNA) small nucleolar RNA host gene 8 (SNHG8) in sepsis and its molecular mechanisms in sepsis-induced inflammation and cardiac dysfunction.

Material And Methods: A total of 126 sepsis patients and 81 healthy controls were enrolled. Serum SNHG8 levels were assessed by RT-qPCR.

Effects of neuromuscular training on dynamic balance ability in athletes: A systematic review and meta-analysis.

Objectives: This study aimed to quantitatively analyze the effects of neuromuscular training (NMT) on dynamic balance in healthy athletes through a systematic review and meta-analysis of randomized controlled trials.

Methods: Searches on six databases for randomized controlled trials examining the impact of NMT on athletes' balance ability. The search period extended from the inception of the database to March 16, 2024, languages are limited to Chinese and English.

The broadband emission of Cr-doped CaYMgGeO and its applications for NIR detectors.

A phosphor-converted light-emitting diode (pc-LED) is a prime light source in smart broadband near-infrared (NIR) spectroscopy. The performance of NIR pc-LEDs crucially depends on the employed NIR luminescent materials. In this study, we synthesized a novel high-efficiency broadband NIR phosphor, CaYMgGeO:Cr (CYMG:Cr).

Machine learning modeling and prognostic value analysis of invasion-related genes in cutaneous melanoma.

In this study, we aimed to develop an invasion-related risk signature and prognostic model for personalized treatment and prognosis prediction in skin cutaneous melanoma (SKCM), as invasion plays a crucial role in this disease. We identified 124 differentially expressed invasion-associated genes (DE-IAGs) and selected 20 prognostic genes (TTYH3, NME1, ORC1, PLK1, MYO10, SPINT1, NUPR1, SERPINE2, HLA-DQB2, METTL7B, TIMP1, NOX4, DBI, ARL15, APOBEC3G, ARRB2, DRAM1, RNF213, C14orf28, and CPEB3) using Cox and LASSO regression to establish a risk score. Gene expression was validated through single-cell sequencing, protein expression, and transcriptome analysis.

The Impact of Household Debt on the Health of the Elderly in China: Evidence from China Family Panel Studies.

With the aging of China's population and the expansion of household debt, the health of the elderly has become an important social issue. Based on the 2018 China Family Panel Studies (CFPS) database, we explored the impact of household debt on the health of older adults and the mechanism of transmission. The Oprobit and IV-Oprobit models were employed for our analysis.

Enhanced Photoluminescence of GdAlGaO: Cr by Energy Transfers from Co-Doped Dy.

LEDs for plant lighting have attracted wide attention and phosphors with good stability and deep-red emission are urgently needed. Novel Cr3+ and Dy3+ co-doped Gd3Al4GaO12 garnet (GAGG) phosphors were successfully prepared through a conventional solid-state reaction. Using blue LEDs, a broadband deep-red emission at 650−850 nm was obtained due to the Cr3+ 4T2 → 4A2 transition.

A solution for the rational dispatching of concrete transport vehicles.

The amount of concrete needed in the construction of projects is enormous. The concrete dispatching in construction is, however, chaotic and causes grievous waste due to the tight construction schedule, heavy tasks, and improper transport vehicle dispatching by the constructor. This paper proposes a more realistic objective function in the vehicle dispatching algorithm and offers a solution to the rational dispatching of concrete transport vehicles.

Discovery of Novel cccDNA Reducers toward the Cure of Hepatitis B Virus Infection.

Chronic hepatitis B virus (HBV) infection is a worldwide disease that causes thousands of deaths per year. Currently, there is no therapeutic that can completely cure already infected HBV patients due to the inability of humans to eliminate covalently closed circular DNA (cccDNA), which serves as the template to (re)initiate an infection even after prolonged viral suppression. Through phenotypic screening, we discovered xanthone series hits as novel HBV cccDNA reducers, and subsequent structure optimization led to the identification of a lead compound with improved antiviral activity and pharmacokinetic profiles.

The Nonlinear Influence of Environmental Regulation on the Transformation and Upgrading of Industrial Structure.

This paper measures the transformation and upgrading of industrial structure from two aspects of rationalization and upgrading of industrial structure, and empirically analyzes the impact of environmental regulation on industrial structure transformation and upgrading by using data of 29 provinces in China from 2004 to 2015. It was found that there is a significant nonlinear effect between environmental regulation and the transformation and upgrading of industrial structure. Specifically, environmental regulation is not conducive to the rational development of industrial structure, but with the continuous improvement of economic development level and human capital level, the inhibitory effect of environmental regulation on the rationalization of industrial structure is gradually weakened.

Discovery of 3-Pyridyl Isoindolin-1-one Derivatives as Potent, Selective, and Orally Active Aldosterone Synthase (CYP11B2) Inhibitors.

Aldosterone synthase (CYP11B2) inhibitors have been explored in recent years as an alternative therapeutic option to mineralocorticoid receptor (MR) antagonists to reduce elevated aldosterone levels, which are associated with deleterious effects on various organ systems including the heart, vasculature, kidney, and central nervous system (CNS). A benzamide pyridine hit derived from a focused screen was successfully developed into a series of potent and selective 3-pyridyl isoindolin-1-ones CYP11B2 inhibitors. Our systematic structure-activity relationship study enabled us to identify unique structural features that result in high selectivity against the closely homologous cortisol synthase (CYP11B1).

Strategies to approach high performance in Cr-doped phosphors for high-power NIR-LED light sources.

Broadband near-infrared (NIR)-emitting phosphors are key for next-generation smart NIR light sources based on blue LEDs. To achieve excellent NIR phosphors, we propose a strategy of enhancing the crystallinity, modifying the micromorphology, and maintaining the valence state of Cr in CaScSiO garnet (CSSG). By adding fluxes and sintering in a reducing atmosphere, the internal quantum efficiency (IQE) is greatly enhanced to 92.

Antioxidant Capacity, Metal Contents, and Their Health Risk Assessment of Tartary Buckwheat Teas.

Tartary buckwheat tea (TBT) is the most popular and widely consumed buckwheat product in many countries. However, the perfect quality control standards for TBT were still lacking, and the content of heavy metals in TBT and their health risks to consumers were still unknown. In this research, the total phenolic content, total flavonoid content, and antioxidant capacity as well as six metal contents and their health risks in TBT were detected.

Electron-phonon coupling mechanisms of broadband near-infrared emissions from Cr in the CaScSiO garnet.

Cr in the CaScSiO garnet (CSSG) has the ability to convert blue light to broadband near-infrared (NIR) emissions, which is a promising strategy for next-generation smart NIR light sources based on blue LEDs. The Cr luminescence strongly depends on temperature due to electron-phonon coupling (EPC). We reveal the EPC mechanism of Cr in CSSG for the first time by temperature-dependent photoluminescence measurement from 77 to 573 K and cathodoluminescence using a scanning electron microscope.

YAG:Ce Transparent Ceramic Phosphors Brighten the Next-Generation Laser-Driven Lighting.

Y Al O :Ce (YAG:Ce ) transparent ceramic phosphors (TCPs) are regarded as the most promising luminescent converter for laser-driven (LD) lighting. High-quality YAG:Ce TCPs are still urgent for high efficiency LD lighting devices. YAG:Ce TCPs in a vacuum ambience by using nano-sized raw materials are prepared.

Inhibitory Effect of Sirtuin6 (SIRT6) on Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells.

BACKGROUND The imbalance between bone resorption and formation is the basic mechanism underlying osteoporosis in the elderly. Osteogenesis is the differentiation of human mesenchymal stem cells (hMSCs) into osteoblasts. Sirtuin6 (SIRT6) regulates various biological functions, including differentiation.

Discovery of Ziresovir as a Potent, Selective, and Orally Bioavailable Respiratory Syncytial Virus Fusion Protein Inhibitor.

Ziresovir (RO-0529, AK0529) is reported here for the first time as a promising respiratory syncytial virus (RSV) fusion (F) protein inhibitor that currently is in phase 2 clinical trials. This article describes the process of RO-0529 as a potent, selective, and orally bioavailable RSV F protein inhibitor and highlights the in vitro and in vivo anti-RSV activities and pharmacokinetics in animal species. RO-0529 demonstrates single-digit nM EC potency against laboratory strains, as well as clinical isolates of RSV in cellular assays, and more than one log viral load reduction in BALB/c mouse model of RSV viral infection.

Transparent Ceramics Enabling High Luminous Flux and Efficacy for the Next-Generation High-Power LED Light.

By designing novel chemical compositions and controlling precursor powders, perfect transparent ceramics (TCs) of GdAlGaO:2%Ce garnets (GAGG:2%Ce) were achieved for the first time. Ce distributions in ceramics were revealed by micromorphology and micro-cathodoluminescence. Benefiting from the components that are rich in red emission, warm light with a correlated color temperature of about 2800 K was generated when TC was used in high-power (hp) blue light emitting diodes (LEDs) (∼450 nm, ∼34 W driven at 1 A).

Warm White Light with a High Color-Rendering Index from a Single GdAlGaO:Ce Transparent Ceramic for High-Power LEDs and LDs.

Transparent ceramics (TCs) are promising for high-power (hp) white light-emitting diode (WLED) and laser diode (LD) lighting. However, comfortable warm white light has not been achieved only using a single TC in hp-WLEDs/LDs. Herein, highly transparent GdAlGaO:Ce (GAGG:Ce) TCs (transmittance, T = 55.

Discovery of Benzoazepinequinoline (BAQ) Derivatives as Novel, Potent, Orally Bioavailable Respiratory Syncytial Virus Fusion Inhibitors.

A novel benzoazepinequnoline (BAQ) series was discovered as RSV fusion inhibitors. BAQ series originated from compound 2, a hit from similarity-based virtual screening. In SAR exploration, benzoazepine allowed modifications in the head moiety.

Highly Efficient and Thermally Stable Blue-Green (BaEuO)(AlO) Phosphor through Structural Modification.

Exploring phosphors with high quantum efficiency (QE) and thermal stability is an important issue for their application in white light-emitting diodes (LEDs). In this work, the crystal structure and luminescent properties of Eu-activated aluminate phosphors with a normal composition (BaEuO)(AlO) (short for BAO:0.2Eu) were studied.

Association between single nucleotide polymorphism rs11057401 of CCDC92 gene and the risk of coronary heart disease (CHD).

Background: Given that the CCDC92 (coiled-coil domain containing 92) was important in insulin resistance, we sought to investigate whether the CCDC92 rs825476 SNP is associated with the risk of CHD in Chinese Han population.

Methods: Rs11057401 was genotyped for 817 patients with CHD and 724 age- and sex-matched controls using PCR-based Invader assay with the probe sets designed and synthesized by third wave.

Results: Patients were found to have a significantly higher frequency of AA than the controls (23.

A two-step solid-state reaction to synthesize the yellow persistent GdAlGaO:Ce phosphor with an enhanced optical performance for AC-LEDs.

By using a two-step solid-state reaction to synthesize the yellow-persistent GdAlGaO:Ce phosphor, both the luminescence and afterglow properties were greatly enhanced. Its internal quantum efficiency reaches as high as 81.9%, indicating its promising application in reducing the flicker effect in AC-LED-based white light systems.

Anneal-induced transformation of phase structure, morphology and luminescence of GdPO:Sm nanomaterials synthesized by a hydrothermal method.

GdPO·HO:xSm nanomaterials were synthesized via a facile hydrothermal method and the effects of Sm concentrations and annealing temperature on the crystal structures, morphologies, and luminescent properties were studied. Doping of Sm exhibited no obvious influence on the crystal structure for the non-annealed samples, which possessed a hexagonal structure and a nanorod shape. Under 401 nm excitation, GdPO·HO:xSm displays a typical emission band with several peaks at 560, 596, and 640 nm.