Deficiency of voltage-gated proton channel Hv1 aggravates ovalbumin-induced allergic lung asthma in mice.

Asthma is a chronic airway inflammation that caused by many factors. The voltage-gated proton channel Hv1 has been proposed to extrude excessive protons produced by NADPH oxidase (NOX) from cytosol to maintain its activity during respiratory bursts. Here, we showed that loss of Hv1 aggravates ovalbumin (OVA)-induced allergic lung asthma in mice.

[Preliminary report for treatment of discogenic low back pain with combined percutaneous laser and O2-O3 mixture].

Objective: To evaluate the efficacy of percutaneous laser and O2-O3 mixture in treating chronic discogenic low back pain.

Methods: There were 48 patients included 32 male and 16 female with the mean age of 43.5 years (range, from 21 to 66 years).