Publications by authors named "Yongfa Huang"

"No-donor" liver transplantation.

Hepatobiliary Pancreat Dis Int

November 2024

Liver transplantation is hindered by organ shortage. The potential way to relieve this issue is to expand the donor pool via extending the donor criteria and make full use of all available grafts. The concept of "no-donor" liver transplantation allows grafts to be recovered from other liver recipients.

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Cell-laden bioprinting is a promising biofabrication strategy for regenerating bioactive transplants to address organ donor shortages. However, there has been little success in reproducing transplantable artificial organs with multiple distinctive cell types and physiologically relevant architecture. In this study, an omnidirectional printing embedded network (OPEN) is presented as a support medium for embedded 3D printing.

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Article Synopsis
  • High oxygen electrocatalytic overpotential in wearable zinc-air batteries (ZABs) leads to low energy conversion efficiency due to slow reaction kinetics.
  • The research uses lignin to partially replace polyacrylonitrile in creating flexible freestanding air electrodes (FFAEs) that feature optimal pore structures and increased electron transfer, enhancing their performance in oxygen reduction and evolution reactions.
  • The resulting N-doped hollow carbon fiber films (NHCFs) demonstrate excellent bifunctional performance and stability in rechargeable ZABs, paving the way for more efficient metal-free electrochemical energy devices.
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Background: Early identification of patients with high mortality risk is critical for optimizing the clinical management of drug-induced liver injury (DILI). We aimed to develop and validate a new prognostic model to predict death within 6 months in DILI patients.

Methods: This multicenter study retrospectively reviewed the medical records of DILI patients admitted to three hospitals.

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Article Synopsis
  • Ectopic secretion of parathyroid hormone (PTH) can cause hypercalcemia, a rare occurrence in patients with cancer, as demonstrated in a 56-year-old woman with endometrial carcinoma.
  • The patient's life-threatening hypercalcemia was linked to PTH production by the tumor, and was alleviated following cytoreductive surgery (CRS) that confirmed the cancer as MMR-deficient.
  • Despite chemotherapy and immunotherapy, the woman's condition worsened, leading to multiple organ failure and her death roughly five months after the surgery, marking a unique case of hypercalcemia from a specific type of cancer with an unusual complication.
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Single-atom catalysts (SACs) show great potential for rechargeable Zn-air batteries (ZABs); however, scalable production of SACs from sustainable resources is difficult owing to poor control of the local coordination environment. Herein, lignosulfonate, a by-product of the papermaking industry, is utilized as a multifunctional bioligand for the mass production of SACs with highly active MN S sites (M represents Fe, Cu, and Co) via strong metalnitrogen/sulfur coordination. This effectively adjusts the charge distribution and promotes the catalytic performance, leading to highly durable and excellent performance in oxygen reduction and evolution reactions for ZABs.

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Exploring advanced electrochemical energy storage systems and clarifying their charge storage mechanisms are key scientific frontiers presenting a great challenge. Herein, we demonstrate a novel concept of Li-ion supercabatteries (, Li-ion capacitors/batteries, LICBs), which were realized using a novel trimetallic Ni-Co-Mn perovskite fluoride (KNiCoMnF, denoted as KNCMF-111 (8)) anode and a high-performance activated carbon/LiFePO (AC/LFP) cathode, which makes the boundary between LICs and LIBs less distinctive. Thanks to the pseudocapacitive conversion mechanism of the KNCMF-111 (8) anode with superior kinetics and the enhanced capacity of the capacitor/battery hybrid AC/LFP cathode, the designed KNCMF-111 (8)//AC/LFP LICBs, integrating the synergistic superiority of pseudocapacitive, capacitive and faradaic characteristics, exhibit remarkable energy/power densities and a long cycle life, indicating a high-efficiency energy storage application.

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Two-dimensional (2D) material-based hydrogels have been widely utilized as the ink for extrusion-based 3D printing in various electronics. However, the viscosity of the hydrogel ink is not high enough to maintain the self-supported structure without architectural deformation. It is also difficult to tune the microstructure of the printed devices using a low-viscosity hydrogel ink.

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Objectives: This study aimed to investigate whether there are sex differences in clinical characteristics and prognosis in patients with primary thrombotic antiphospholipid syndrome (ptAPS).

Methods: From January 2013 to July 2021, 154 consecutive patients diagnosed with ptAPS were prospectively recruited. Multivariable Cox regression was used to evaluate the association between gender and the composite endpoint including thromboembolic recurrence or all-cause death during follow-up.

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A cost-effective perovskite fluoride KCuF material has been introduced as an advanced anode for lithium-ion capacitors (LICs) and lithium-dual-ion batteries (Li-DIBs), showing a conversion mechanism and pseudocapacitive kinetics for Li ion storage.

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A novel concept of Na-based dual-ion batteries (Na-DIBs) has been designed via a perovskite K0.79Ni0.25Co0.

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Na-ion capacitors (NICs) and Na-based dual-ion batteries (Na-DIBs) have been considered to be promising alternatives to traditional lithium-ion batteries (LIBs) because of the abundance and low cost of the Na-ion, but their energy density, power density and life cycle are limited. Herein, dual-vacancy (including K and F vacancies) perovskite fluoride K MnF @reduced graphene oxide (rGO; recorded as Mn-G) as anode for NICs and Na-DIBs has been developed. The special conversion/intercalation dual Na-ion energy storage mechanism and pseudocapacitive dynamics are analyzed in detail.

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Objective: Myocardial involvement (MCI) is known to increase morbidity and mortality in polymyositis (PM) and dermatomyositis (DM). This study aims to investigate whether complicating with ventricular arrhythmia (VA) predicts poor outcomes in patients with PM/DM-related myocardial involvement (PM/DM-MCI).

Methods: We reviewed all PM/DM-MCI patients admitted to Peking Union Medical College Hospital from October 1997 to April 2019.

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Right ventricular (RV) failure is a major cause of death in patients with pulmonary arterial hypertension, and the mechanism of RV failure remains unclear. While the malfunction of RyR2 (ryanodine receptor type 2) on sarcoplasmic reticulum (SR) and aberrant Ca cycling in cardiomyocytes have been recognized in some cardiovascular diseases, their roles in RV failure secondary to pulmonary arterial hypertension require further investigation. In a monocrotaline-induced rat model of pulmonary arterial hypertension, the RV remodeling process was divided into normal, compensated, and decompensated stages according to the hemodynamic and morphological parameters.

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Trimetallic NiCoMo/graphene (NCM/G 811) multifunctional electrocatalysts demonstrate remarkable catalytic activity, fast kinetics, a low onset potential and high stability towards alkaline urea oxidation reaction (UOR). Moderate structural/electronic effects among Ni, Co and Mo species are responsible for the outstanding catalytic behavior.

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Background: The clinical features, angiographic findings, and outcomes have not been compared between pediatric and adult patients with Takayasu arteritis (TA) with coronary involvement.

Methods: Of 1056 consecutive patients with TA hospitalized and followed from 1990 to 2018 in our hospital, 38 patients including 9 children and 29 adults (mean age at diagnosis of 14.3 ± 3.

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Cost-competitive perovskite fluoride KZnF has been introduced for the first time as an advanced anode for high-performance lithium-based dual-ion batteries, exhibiting conversion/alloying hybrid mechanisms and dominated pseudocapacitive kinetics for Li-ion storage.

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