Publications by authors named "Yongchul Song"
Article Synopsis
- Targeted therapies are effective for systemic cancer treatment but struggle with brain metastases, leading to poor control over these lesions.
- In breast cancer models, even with drug accumulation in brain metastases, they can bypass the effects of PI3K inhibitors, partly due to increased HER3 expression and activation.
- Blocking HER3 can sensitize resistant brain metastases to PI3K inhibitors, resulting in reduced tumor growth and improved survival in experimental models, suggesting new treatment strategies for certain breast cancer patients.
