Exercise as an antidepressant: exploring its therapeutic potential.

The COVID-19 pandemic has increased the prevalence of depressive disorders worldwide, requiring alternative treatments beyond medication and psychotherapy. Exercise has positive effects on the brain; therefore, it has emerged as a promising therapeutic option for individuals with depression. Considerable research involving humans and animals offers compelling evidence to support the mental health benefits of physical activity or exercise mediated by the regulation of complex theoretical paradigms.

Post-consumer plastic packaging waste from online food delivery services in South Korea.

Along with the rapid growth of the food delivery industry, concerns are growing regarding the management of plastic packaging waste. This study estimates the amount of plastic packaging from online food delivery services in Korea and assesses its environmental effects using life cycle assessments. This study also compares the environmental impacts of the adoption of multi-use containers, the use of recycled materials, and the increase in recycling rates proposed by the Korean government for efficient plastic waste management.

Treadmill Exercise Alleviates Brain Iron Dyshomeostasis Accelerating Neuronal Amyloid-β Production, Neuronal Cell Death, and Cognitive Impairment in Transgenic Mice Model of Alzheimer's Disease.

Brain iron increases with age and abnormal brain iron metabolism is proving increasingly likely to be involved in the pathology of Alzheimer's disease (AD). The iron-regulatory effect of furin, a ubiquitously expressed proconvertase, might play an important role in AD. Therefore, there is an urgent need to study the effect of furin on iron regulation in AD.

Endurance Exercise-Induced Autophagy/Mitophagy Coincides with a Reinforced Anabolic State and Increased Mitochondrial Turnover in the Cortex of Young Male Mouse Brain.

Autophagy/mitophagy, a cellular catabolic process necessary for sustaining normal cellular function, has emerged as a potential therapeutic strategy against numerous obstinate diseases. In this regard, endurance exercise (EXE)-induced autophagy/mitophagy (EIAM) has been considered as a potential health-enriching factor in various tissues including the brain; however, underlying mechanisms of EIAM in the brain has not been fully defined yet. This study investigated the molecular signaling nexus of EIAM pathways in the cortex of the brain.

Endurance exercise-induced expression of autophagy-related protein coincides with anabolic expression and neurogenesis in the hippocampus of the mouse brain.

Autophagy and neurogenesis play a pivotal role in maintaining cellular homeostasis of neurons in the brain. Endurance exercise (EXE) serves as a potent regulator of both autophagy and neurogenesis in the hippocampus of the brain; however, the underlying molecular mechanisms of the dual expression remains unclear. Thus, we examined the signaling pathways of EXE-induced autophagy and neurogenesis-associated protein expression in the hippocampus.

Elevation of hepatic autophagy and antioxidative capacity by endurance exercise is associated with suppression of apoptosis in mice.

Introduction And Objectives: Endurance exercise (EXE) has emerged as a potent inducer of autophagy essential in maintaining cellular homeostasis in various tissues; however, the functional significance and molecular mechanisms of EXE-induced autophagy in the liver remain unclear. Thus, the aim of this study is to examine the signaling nexus of hepatic autophagy pathways occurring during acute EXE and a potential crosstalk between autophagy and apoptosis.

Materials And Methods: C57BL/6 male mice were randomly assigned to sedentary control group (CON, n=9) and endurance exercise (EXE, n=9).

Endurance Exercise Attenuates Doxorubicin-induced Cardiotoxicity.

Purpose: Endurance exercise (EXE) preconditioning before DOX treatment confers cardioprotection; however, whether EXE postconditioning (i.e., EXE intervention after the completion of DOX treatment) is cardioprotective remains unknown.

Endurance Exercise Prevents Metabolic Distress-induced Senescence in the Hippocampus.

Purpose: Metabolic disorder such as obesity and type 2 diabetes caused by excess caloric intake is associated with an increased risk of neurodegenerative diseases. Endurance exercise (EXE) has been suggested to exert neuroprotective effects against the metabolic distress. However, the exact underlying molecular mechanisms responsible for the exercise-induced neuroprotection have not been fully elucidated.

Modulation of mitochondrial phenotypes by endurance exercise contributes to neuroprotection against a MPTP-induced animal model of PD.

Aim: Endurance exercise (EE) has been reported to confer neuroprotection against Parkinson's disease (PD); however, underlying molecular mechanisms of the protection remain still unclear. Since mitochondrial impairment is commonly observed in the brain of PD patients and animals, this study investigated whether EE-induced neuroprotection is associated with mitochondrial phenotypes, using a mouse model of PD induced by intraperitoneal administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).

Main Methods: SH-SY5Y cells were cultured with a neurotoxin MPP known to cause PD-like symptoms to examine if modifications of mitochondrial morphology are linked to etiology of PD.

Endurance Exercise Mediates Neuroprotection Against MPTP-mediated Parkinson's Disease via Enhanced Neurogenesis, Antioxidant Capacity, and Autophagy.

Parkinson's disease (PD) is a neurodegenerative disorder caused by loss of dopaminergic neurons in the substantia nigra, leading to motor dysfunction. Growing evidence has demonstrated that endurance exercise (EE) confers neuroprotection against PD. However, the exact molecular mechanisms responsible for exercise-induced protection of dopaminergic neurons in PD remain unclear.

Correction to: Potential signaling pathways of acute endurance exercise-induced cardiac autophagy and mitophagy and its possible role in cardioprotection.

The article Potential signaling pathways of acute endurance exercise-induced cardiac autophagy and mitophagy and its possible role in cardioprotection, written by Youngil Lee.

Potential signaling pathways of acute endurance exercise-induced cardiac autophagy and mitophagy and its possible role in cardioprotection.

Cardiac myocytes are terminally differentiated cells and possess extremely limited regenerative capacity; therefore, preservation of mature cardiac myocytes throughout the individual's entire life span contributes substantially to healthy living. Autophagy, a lysosome-dependent cellular catabolic process, is essential for normal cardiac function and mitochondria maintenance. Therefore, it may be reasonable to hypothesize that if endurance exercise promotes cardiac autophagy and mitochondrial autophagy or mitophagy, exercise-induced cardiac autophagy (EICA) or exercise-induced cardiac mitophagy (EICM) may confer propitious cellular environment and thus protect the heart against detrimental stresses, such as an ischemia-reperfusion (I/R) injury.

Treadmill exercise produces neuroprotective effects in a murine model of Parkinson's disease by regulating the TLR2/MyD88/NF-κB signaling pathway.

Parkinson's disease (PD) is characterized by progressive dopamine depletion and a loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc). Treadmill exercise is a promising non-pharmacological approach for reducing the risk of PD and other neuroinflammatory disorders, such as Alzheimer's disease. The goal of this study was to investigate the effects of treadmill exercise on α-synuclein-induced neuroinflammation and neuronal cell death in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mouse model of PD.

Long-term resistance exercise-induced muscular hypertrophy is associated with autophagy modulation in rats.

Elevation of anabolism and concurrent suppression of catabolism are critical metabolic adaptations for muscular hypertrophy in response to resistance exercise (RE). Here, we investigated if RE-induced muscular hypertrophy is acquired by modulating a critical catabolic process autophagy. Male Wistar Hannover rats (14 weeks old) were randomly assigned to either sedentary control (SC, n = 10) or resistance exercise (RE, n = 10).

Neuroprotective effects of endurance exercise against neuroinflammation in MPTP-induced Parkinson's disease mice.

Parkinson's disease (PD) is one of the main degenerative neurological disorders accompanying death of dopaminergic neurons prevalent in aged population. Endurance exercise (EE) has been suggested to confer neurogenesis and mitigate the degree of seriousness of PD. However, underlying molecular mechanisms responsible for exercise-mediated neuroprotection against PD remain largely unknown.

Substance flow analysis and environmental releases of PBDEs in life cycle of automobiles.

Polybrominated diphenyl ethers (PBDEs), a class of brominated flame retardants, have been widely used in many applications in industry such as automobiles, textiles, and electronics. This study focused on a quantitative substance flow analysis (SFA) of PBDEs in automobiles in order to identify their flow by life cycle and treatment pathways of PBDEs-containing materials in end-of-life vehicles (ELVs) in Korea. In addition, this study has estimated environmental releases of PBDEs in automobiles by life cycle in Korea.

Static and dynamic flow analysis of PBDEs in plastics from used and end-of-life TVs and computer monitors by life cycle in Korea.

This study focused on a quantitative substance flow analysis (SFA) of polybrominated diphenyl ethers (PBDEs) in plastics from obsolete TVs and computer monitors that often contain large amounts of the flame retardants. According to the results of the static SFA study, 1.87 tons and 0.

Application of Delphi-AHP methods to select the priorities of WEEE for recycling in a waste management decision-making tool.

The management of waste electrical and electronic equipment (WEEE) or electronic waste (e-waste) has become a major issue of concern for solid waste communities due to the large volumes of waste being generated from the consumption of modern electrical and electronic products. In 2003, Korea introduced the extended producer responsibility (EPR) system to reduce the amount of electronic products to be disposed and to promote resource recovery from WEEE. The EPR currently regulates a total of 10 electrical and electronic products.

The behavior and long-term fate of metals in simulated landfill bioreactors under aerobic and anaerobic conditions.

The long-term behavior and fate of metals in leachate from four simulated bioreactor landfills were explored using lysimeters under both aerobic and anaerobic conditions for a maximum of 1650 days. Metal concentrations varied with time and stage of landfill activity. The behavior of selected metals (Al, As, Cr, Cu, Fe, Pb, and Zn) significantly differed between aerobic and anaerobic conditions.

Characterization of roadway stormwater system residuals for reuse and disposal options.

The chemical characterization of sediments accumulated in catch basins and stormwater ponds provides important information for assessing risks associated with management of these residuals upon removal of accumulated deposits in stormwater systems. In this study, over a period of 15 months, more than 150 residual samples were collected from 77 catch basin units and 22 stormwater ponds from 16 municipalities throughout the state of Florida. Concentrations (mg/kg) of metals and metalloids (arsenic, barium, cadmium, chromium, copper, lead, mercury, nickel, selenium, silver, and zinc) and trace organics (volatile organics, semi-volatile organics, herbicides, and pesticides) in the sediments were measured.

Characterization of pollutants in Florida street sweepings for management and reuse.

Disposal and beneficial-use options for street sweeping residuals collected as part of routine roadway maintenance activities in Florida, USA, were assessed by characterizing approximately 200 samples collected from 20 municipalities. Total concentrations (mg/kg or microg/kg) and leachable concentrations (mg/L or microg/L) of 11 metals and a number of organic pollutant groups (volatile organics, semi-volatile organics, pesticides, herbicides, carbamates) in the samples were measured. The synthetic precipitation leaching procedure (SPLP) was performed to evaluate the leachability of the pollutants.

Distribution and mobility of chromium, copper, and arsenic in soils collected near CCA-treated wood structures in Korea.

Chromated copper arsenate (CCA) is currently the most commonly used wood preservative in Korea. Questions, however, have been raised regarding the potential environmental impacts of metal leaching from CCA-treated wood to soil. Although a number of researchers from other countries have reported that chromium, copper, and arsenic do leach from CCA-treated wood over time, to date few field studies have been performed on those metals in soils adjacent to CCA-treated wood structures in Korea.

RCRA toxicity characterization of discarded electronic devices.

The potential for discarded electronic devices to be classified as toxicity characteristic (TC) hazardous waste under provisions of the Resource Conservation and Recovery Act (RCRA) using the toxicity characteristic leaching procedure (TCLP) was examined. The regulatory TCLP method and two modified TCLP methods (in which devices were disassembled and leached in or near entirety) were utilized. Lead was the only element found to leach at concentrations greater than its TC limit (5 mg/L).

Medical waste management in Korea.

The management of medical waste is of great importance due to its potential environmental hazards and public health risks. In the past medical waste was often mixed with municipal solid waste and disposed of in residential waste landfills or improper treatment facilities (e.g.