Publications by authors named "Yongchen Cui"
Peripheral nerve injury (PNI), typically caused by traumatic accidents or medical events, is currently one of the most common diseases that leads to limb disability. After PNI, tetrodotoxin-resistant voltage-gated sodium channel Nav1.8 is upregulated at the lesion site.
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- Fospropofol disodium is a new sedation drug that may offer better effects than traditional propofol, specifically for elderly patients undergoing same-day bidirectional endoscopy.
- The study involves 256 elderly participants, split evenly between fospropofol and propofol groups, to compare sedation success rates, how quickly sedation is achieved, and patient recovery times.
- Researchers aim to determine if fospropofol is as effective and safe as propofol, with hopes of establishing it as a preferred option for sedation in these medical procedures.
Background: Continuous nerve block with ropivacaine is commonly performed after repair surgery for traumatic peripheral nerve injuries. After peripheral nerve injury, tetrodotoxin-resistant voltage-gated sodium channel Nav1.8 is upregulated and contributes to macrophage inflammation.
View Article and Find Full Text PDFSevoflurane preconditioning has been proved to possess therapeutic effects on stress. However, the mechanism by which sevoflurane preconditioning protects against stress remains unclear. In this study, an acute model of heat stress in C.
View Article and Find Full Text PDFBackground: Microglial polarization toward pro-inflammatory M1 phenotype are major contributors to the development of perioperative neurocognitive disorders (PNDs). Metabolic reprogramming plays an important role in regulating microglial polarization. We therefore hypothesized that surgical trauma can activate microglial M1 polarization by metabolic reprogramming to induce hippocampal neuroinflammation and subsequent postoperative cognitive impairment.
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