Hybrid membrane based biomimetic nanodrug with high-efficient melanoma-homing and NIR-II laser-amplified peroxynitrite boost properties for enhancing antitumor therapy via effective immunoactivation.

Owing to the excellent stability, anticancer activity and immunogenicity, peroxynitrite (ONOO) has been gained enormous interests in cancer therapy. Nevertheless, precise delivery and control release of ONOO in tumors remains a big challenge. Herein, B16F10 cancer cell membrane/liposome hybrid membrane (CM-Lip) based biomimetic nanodrug with high-efficient tumor-homing and NIR-II laser controlled ONOO boost properties was designed for melanoma treatment.

Construction of lymph nodes-targeting tumor vaccines by using the principle of DNA base complementary pairing to enhance anti-tumor cellular immune response.

Tumor vaccines, a crucial immunotherapy, have gained growing interest because of their unique capability to initiate precise anti-tumor immune responses and establish enduring immune memory. Injected tumor vaccines passively diffuse to the adjacent draining lymph nodes, where the residing antigen-presenting cells capture and present tumor antigens to T cells. This process represents the initial phase of the immune response to the tumor vaccines and constitutes a pivotal determinant of their effectiveness.

Stimuli-responsive azobenzene-quantum dots for multi-sensing of dithionite, hypochlorite, and azoreductase.

A new fluorescence turn-on sensing platform has been developed applicable for sensitive profiling of multiple chemical and biological analytes, using azobenzene-quantum dot as a new stimuli-responsive optical nanoprobe. An azobenzene-carrying compound bis [4, 4'-(dithiophenyl azo)-1, 3-benzenediamine] (DTPABDA) is for the first time reported to be used for conjugation with CdSe/ZnS core/shell quantum dots (QDs) via the ligand exchange reaction. Due to the photo-induced electron-transfer (PET) effect, the electron-withdrawing azobenzene groups of DTPABDA can significantly cause the photoluminescence (PL) of QDs quenched.

π-π stacking-directed self-assembly of nanoplatelets into diversified three-dimensional superparticles for high surface-enhanced Raman scattering.

Ordered, hierarchical structures formed from nanoparticle (NP) self-assembly are of interest as they display the synergistic properties of the individual NP. Herein we report a one-pot approach to form and self-assemble gold (Au) nanoplatelets into brick-wall like (BWL) Au superparticles (AuSPs). We employ an aniline (ANI) derivative, N-(3-amidino)-aniline (NAAN) to reduce the Au precursor into Au nanoplatelets in the presence of Br.