Inferring gene regulatory network from single-cell transcriptomic data by integrating multiple prior networks.

Gene regulatory network models the interactions between transcription factors and target genes. Reconstructing gene regulation network is critically important to understand gene function in a particular cellular context, providing key insights into complex biological systems. We develop a new computational method, named iMPRN, which integrates multiple prior networks to infer regulatory network.

TriPCE: A Novel Tri-Clustering Algorithm for Identifying Pan-Cancer Epigenetic Patterns.

Epigenetic alteration is a fundamental characteristic of nearly all human cancers. Tumor cells not only harbor genetic alterations, but also are regulated by diverse epigenetic modifications. Identification of epigenetic similarities across different cancer types is beneficial for the discovery of treatments that can be extended to different cancers.

Identification of cancer subtypes from single-cell RNA-seq data using a consensus clustering method.

Background: Human cancers are complex ecosystems composed of cells with distinct molecular signatures. Such intratumoral heterogeneity poses a major challenge to cancer diagnosis and treatment. Recent advancements of single-cell techniques such as scRNA-seq have brought unprecedented insights into cellular heterogeneity.