Nobiletin regulates the proliferation and migration of ovarian cancer A2780 cells via DPP4 and TXNIP.

Nobiletin is an active compound extracted from citrus fruits. Research has indicated that nobiletin has a potential inhibitory effect on ovarian cancer (OV). However, the mechanism of action remains unclear.

polysaccharides attenuates pressure-overload-induced pathological cardiac hypertrophy.

Pathological cardiac hypertrophy is an important risk factor for cardiovascular disease. However, drug therapies that can reverse the maladaptive process and restore heart function are limited. polysaccharides (GLPs) are one of the main active components of (), and they have various pharmacological effects.

Syngas production and gas-N evolution over heterogeneously doped La-Fe-O perovskite-type oxygen carriers in chemical looping gasification of microalgae.

Chemical looping gasification (CLG) is a promising technology for syngas production with low pollutant emission. In this study, doped La-Fe-O perovskites including LaFeO (LF), LaFeNiO (LN5F5) and LaBaFeO (L3B7F) were developed for microalgae CLG. The as-prepared perovskites exhibited an outstanding performance in syngas production with accumulative syngas yield > 33 mol/kg.

A new environmentally-friendly route to form a high-corrosion-resistant nesquehonite film on pure magnesium.

Magnesium-based materials are promising lightweight structural materials due to their excellent properties. However, their extensive application has been severely limited due to their high corrosion susceptibility. The inadequate corrosion resistance of Mg is mainly attributed to the porous and unprotective native surface film formed on Mg in aggressive environments.

Synergistic effect of bone marrow-derived mesenchymal stem cells and platelet-rich plasma in streptozotocin-induced diabetic rats.

Background: Diabetic wounds are a major clinical challenge, because minor skin wounds can lead to chronic, unhealed ulcers and ultimately result in infection, gangrene, or even amputation. Studies on bone marrow derived mesenchymal stem cells (BMSCs) and a series of growth factors have revealed their many benefits for wound healing and regeneration. Platelet-rich plasma (PRP) may improve the environment for BMSC development and differentiation.

[Effect of bufalin on cellular proliferation and apoptosis in human esophageal squamous carcinoma EC9706 cells].

Objective: To investigate the effect of bufalin on nucleus-mitochondria localization of human telomerase reverse transcriptase(hTERT) by exploring its effect on proliferation and apoptosis in human esophageal squamous carcinoma EC9706 cells.

Methods: EC9706 cells were treated with bufalin at various concentrations, and then the cell growth inhibition of EC9706 cells was examined by CCK-8 assay and the 50% inhibitory concentration (IC(50)) was calculated.Cell cycle analysis was performed by flow cytometry with PI staining, and nucleus morphology of apoptosis were observed by fluorescence microscopy with Hoechst 33342 staining.

Attenuation of high-glucose-induced inflammatory response by a novel curcumin derivative B06 contributes to its protection from diabetic pathogenic changes in rat kidney and heart.

There is increasing evidence indicating that inflammatory processes are involved in the development and progression of diabetic complications. However, effective anti-inflammatory treatments for patients who have diabetic complications have yet been practically identified. Curcumin is a main component of Curcuma longa with numerous pharmacological activities.

bFGF inhibits ER stress induced by ischemic oxidative injury via activation of the PI3K/Akt and ERK1/2 pathways.

Extensive research has focused on finding effective strategies to prevent or improve recovery from brain ischemia and reperfusion (I/R) injury. The basic fibroblast growth factor (bFGF) has been shown to have therapeutic potential in some central nervous system (CNS) disorders, including ischemic injury. In this study, we demonstrate that bFGF administration can improve locomotor activity and inhibit the ER stress induced in the CA1 region of the hippocampus in a mouse model of I/R injury.