Sex-biased regulatory changes in the placenta of native highlanders contribute to adaptive fetal development.

Compared with lowlander migrants, native Tibetans have a higher reproductive success at high altitude though the underlying mechanism remains unclear. Here, we compared the transcriptome and histology of full-term placentas between native Tibetans and Han migrants. We found that the placental trophoblast shows the largest expression divergence between Tibetans and Han, and Tibetans show decreased immune response and endoplasmic reticulum stress.

Polygenic adaptation leads to a higher reproductive fitness of native Tibetans at high altitude.

The adaptation of Tibetans to high-altitude environments has been studied extensively. However, the direct assessment of evolutionary adaptation, i.e.

Large-scale genome sequencing redefines the genetic footprints of high-altitude adaptation in Tibetans.

Background: Tibetans are genetically adapted to high-altitude environments. Though many studies have been conducted, the genetic basis of the adaptation remains elusive due to the poor reproducibility for detecting selective signatures in the Tibetan genomes.

Results: Here, we present whole-genome sequencing (WGS) data of 1001 indigenous Tibetans, covering the major populated areas of the Qinghai-Tibetan Plateau in China.

Effect of synovial fluid temperature on wear resistance of different polymer acetabular materials.

In order to investigate the effect of frictional heat on the wear resistance characteristics of polymeric acetabular materials, the tribological tests and wear numerical analysis of three common polymer acetabular materials were carried out under different synovial fluid temperatures. The study results show that XLPE and VE-XLPE exhibit superior wear resistance compared to UHMWPE in high-temperature, heavy load environments. The coefficient of friction of three materials gradually decreases as the temperature of the synovial fluid increases.

Seasonality and Sex-Biased Fluctuation of Birth Weight in Tibetan Populations.

Unlabelled: Birth weight (BW) is a key determinant of infant mortality. Previous studies have reported seasonal fluctuation of BW. However, the responsible environmental factors remain disputable.

A comparative analysis of differentially expressed mRNAs, miRNAs and circRNAs provides insights into the key genes involved in the high-altitude adaptation of yaks.

Background: Yaks that inhabit the Tibetan Plateau exhibit striking phenotypic and physiological differences from cattle and have adapted well to the extreme conditions on the plateau. However, the mechanisms used by these animals for the regulation of gene expression at high altitude are not fully understood.

Results: Here, we sequenced nine lung transcriptomes of yaks at altitudes of 3400, 4200 and 5000 m, and low-altitude Zaosheng cattle, which is a closely related species, served as controls.

Precise medicine of programmed cell death-1/programmed cell death 1 ligand 1 inhibitor immunotherapy combined radiotherapy for inoperable advanced lung cancer: A protocol for systematic review and meta-analysis.

Background: Programmed cell death-1/programmed cell death 1 ligand 1 (PD-1/PD-L1) inhibitors are a group of immune checkpoint inhibitors immunotherapy for cancer treatment. These immune checkpoint inhibitors are becoming first-line treatments for several types of cancer. Radiotherapy for cancer is a traditional treatment and the therapeutic effect is not satisfactory due to the side effect of chemotherapeutic drugs.

Molecular mechanisms detected in yak lung tissue via transcriptome-wide analysis provide insights into adaptation to high altitudes.

Due to their long-term colonization of and widespread distribution in plateau environments, yaks can serve as an ideal natural animal model for the adaptive evolution of other plateau species, including humans. Some studies reported that the lung and heart are two key organs that show adaptive transcriptional changes in response to high altitudes, and most of the genes that show differential expression in lung tissue across different altitudes display nonlinear regulation. To explore the molecular mechanisms that are activated in yak lung tissue in response to hypoxia, the mRNAs, lncRNAs and miRNAs of lung tissue from 9 yaks living at three different altitudes (3400 m, 4200 m and 5000 m), with three repetitions per altitude, were sequenced.

Explaining Positional Differences of Performance Profiles for the Elite Female Basketball Players.

The aim of the present study was to explore the differences in technical performances of players considering playing positions by controlling the effect of situational variables in each FIBA female continental basketball competition. Samples of 9,208 observations from 471 games in the America, Africa, Asia, and Europe Championships during 2013-2017 were collected and analyzed by generalized mixed linear modeling. The results showed that Centers from Europe had more 2-point made (ES = 0.

Preparation and electrochemical treatment application of Ti/Sb-SnO-Eu&rGO electrode in the degradation of clothianidin wastewater.

This work investigated the preparation of Ti/Sb-SnO electrode co-doped with graphene and europium and the electrochemical degradation of clothianidin in aqueous solution with Ti/Sb-SnO-Eu&rGO electrode. The physicochemical properties of different electrodes were characterized by using the scanning electron microscopy, X-ray diffraction, oxygen evolution potential and cyclic voltammetry tests. The results indicated that the Ti/Sb-SnO-Eu&rGO electrodes have a compact structure and fine grain size and have a higher oxygen evolution overpotential than Ti/Sb-SnO-None, Ti/Sb-SnO-Eu and Ti/Sb-SnO-rGO electrodes.

Differential U2AF1 mutation sites, burden and co-mutation genes can predict prognosis in patients with myelodysplastic syndrome.

To investigate the U2AF1 gene mutation site, mutation load and co-mutations genes in patients with myelodysplastic syndrome (MDS) and their effects on prognosis. Gene mutation detection by next-generation sequence and related clinical data of 234 MDS patients were retrospectively collected and analyzed for the relationship between the clinical characteristics, treatment efficacy and prognosis of U2AF1 gene mutation. Among the 234 MDS patients, the U2AF1 gene mutation rate was 21.

Tunable dual-band terahertz absorber with all-dielectric configuration based on graphene.

In this paper, we theoretically design a dual-band graphene-based terahertz (THz) absorber combining the magnetic resonance with a THz cold mirror without any metallic loss. The absorption spectrum of the all-dielectric THz absorber can be actively manipulated after fabrication due to the tunable conductivity of graphene. After delicate optimization, two ultra-narrow absorption peaks are achieved with respective full width at half maximum (FWHM) of 0.

The Regional Differences in Game-Play Styles Considering Playing Position in the FIBA Female Continental Basketball Competitions.

The aim of this study was to identify regional differences based on playing position in terms of the technical performances among FIBA Female Continental Basketball Championships by controlling the influence of situational variables including the game outcome, game type, teams and opponent quality. The samples comprised of 9208 performance records from 471 games in the America, Africa, Asia and Europe Championships during 2013-2017 and were collected and analyzed by generalized mixed linear modeling. Our study highlighted that, although positional differences were clear among different continental championships, it is worth noting that African guards, forwards, and centers made more turnovers (TOV) compared with the corresponding positional players from other continental championships.

Effect of early enteral nutrition support for the management of acute severe pancreatitis: A protocol of systematic review.

Background: This study aims to assess the effect of early enteral nutrition support (EENS) for the management of acute severe pancreatitis (ASP).

Methods: This study will search Cochrane Library, PUBMED, EMBASE, Cumulative Index to Nursing and Allied Health Literature, Allied and Complementary Medicine Database, CNKI, and WANGFANG from their inception to the present without language limitations. In addition, this study will also search clinical trial registry and reference lists of included trials.

Atomistic Simulation Study of Nanoparticle Effect on Nano-Cutting Mechanisms of Single-Crystalline Materials.

Nanoparticle (NP), as a kind of hard-to-machine component in nanofabrication processes, dramatically affects the machined surface quality in nano-cutting. However, the surface/subsurface generation and the plastic deformation mechanisms of the workpiece still remain elusive. Here, the nano-cutting of a single-crystalline copper workpiece with a single spherical embedded nanoparticle is explored using molecular dynamics (MD) simulations.

Evaluating genetic diversity and identifying priority conservation for seven Tibetan pig populations in China based on the mtDNA D-loop.

Objective: Tibetan pigs, an excellent species unique to China, face serious threats, which in turn affects the development and utilization of the outstanding advantages of plateau hypoxia adaptability and reduces their genetic diversity. Therefore, a discussion of measures to conserve this genetic resource is necessary. The method, based on genetic diversity, genetic divergence and total genetic contribution rate of population, reflects the priority conservation order and varies depending on the three different purposes of conservation.