L. Oligo-Polysaccharides (CIO) Exerts Antianxiety and Antidepressant Effects on Mice Experiencing Behavioral Despair and Chronic Unpredicted Mild Stress.

L. oligo-polysaccharides (CIOs), obtained from L., is a mixture of oligosaccharides and polysaccharides.

Liver-specific gene PGRMC1 blocks c-Myc-induced hepatocarcinogenesis through ER stress-independent PERK activation.

Roles of liver-specific genes (LSGs) in tumor initiation and progression are rarely explored in hepatocellular carcinoma (HCC). Here we show that LSGs are generally downregulated in HCC tumor tissues compared to non-HCC liver tissues, and low-LSG HCCs show poor prognosis and the activated c-Myc pathway. Among the c-Myc- and patient prognosis-associated LSGs, PGRMC1 significantly blocks c-Myc-induced orthotopic HCC formation.

Topological Synthesis of 2D High-Entropy Multimetallic (Oxy)hydroxide for Enhanced Lattice Oxygen Oxidation Mechanism.

Owing to sluggish reaction kinetics and high potential, oxygen evolution reaction (OER) electrocatalysts face a trade-off between activity and stability. Herein, an innovative topological strategy is presented for preparing 2D multimetallic (oxy)hydroxide, including ternary CoFeZn, quaternary CoFeMnZn, and high-entropy CoFeMnCuZn. The key to the synthesis lies in using Ca-rich brownmillerite oxide as a precursor, which possesses inherent structural flexibility enabling tailored elemental adjustments and topologically transforms from a point-shared structure of metal-oxygen octahedrons into an edge-shared structure under alkaline conditions.

Membrane RRM2-positive cells represent a malignant population with cancer stem cell features in intrahepatic cholangiocarcinoma.

Background: Intrahepatic cholangiocarcinoma (iCCA) is one of the most lethal malignancies and highly heterogeneous. We thus aimed to identify and characterize iCCA cell subpopulations with severe malignant features.

Methods: Transcriptomic datasets from three independent iCCA cohorts (iCCA cohorts 1-3, n = 382) and formalin-fixed and paraffin-embedded tissues from iCCA cohort 4 (n = 31) were used.

Guided Design of Efficient Oxygen Evolution Catalysts Using Patent Analysis.

The facile and rapid design of efficient oxygen evolution reaction (OER) catalysts holds paramount significance for energy conversion devices, such as water electrolyzers and fuel cells. Despite substantial progress in catalyst synthesis and performance exploration, the design and selection processes remain inefficient. In this context, we integrate patent analysis with catalyst design, leveraging the scholarly research functionalities within patent analyses to aid in the design and synthesis of a NiFeRu-carbon catalyst as a high-performance OER catalyst.

Oncogenic Roles of Laminin Subunit Gamma-2 in Intrahepatic Cholangiocarcinoma via Promoting EGFR Translation.

Intrahepatic cholangiocarcinoma (iCCA) is a highly lethal biliary epithelial cancer in the liver. Here, Laminin subunit gamma-2 (LAMC2) with important oncogenic roles in iCCA is discovered. In a total of 231 cholangiocarcinoma patients (82% of iCCA patients) across four independent cohorts, LAMC2 is significantly more abundant in iCCA tumor tissue compared to normal bile duct and non-tumor liver.

Emotions, COVID-19 related thoughts and satisfaction with life during the critical period from control to relaxation.

Introduction: In the context of declining mortality rates and increasing infectivity, it has become unavoidable for the majority of individuals to experience a COVID-19 infection at some point. This study aimed to investigate the psychological well-being of the general population during China's transition period from strict control measures to relaxed policies in COVID-19 prevention and control, as well as the impact of COVID-19 related thoughts on emotion and life satisfaction during widespread infections.

Methods: A cross-sectional study was conducted involving a sample size of 1578 participants.

Facet Engineering and Pore Design Boost Dynamic Fe Exchange in Oxygen Evolution Catalysis to Break the Activity-Stability Trade-Off.

The oxygen evolution reaction (OER) plays a vital role in renewable energy technologies, including in fuel cells, metal-air batteries, and water splitting; however, the currently available catalysts still suffer from unsatisfactory performance due to the sluggish OER kinetics. Herein, we developed a new catalyst with high efficiency in which the dynamic exchange mechanism of active Fe sites in the OER was regulated by crystal plane engineering and pore structure design. High-density nanoholes were created on cobalt hydroxide as the catalyst host, and then Fe species were filled inside the nanoholes.

Global Patterns of Agricultural Investment and Food Security: Evidence from the fDi Markets Database.

The number of hungry people is on the rise and more efforts are needed to improve the global food security status. The Food and Agriculture Organization (FAO) proposes more investment in the agricultural sector to boost production and alleviate hunger. However, there are fewer papers that distinguish enterprises investment from public investment.

S and O Co-Coordinated Mo Single Sites in Hierarchically Porous Tubes from Sulfur-Enamine Copolymerization for Oxygen Reduction and Evolution.

The highly efficient bifunctional catalyst for the oxygen reduction reaction (ORR) and the oxygen evolution reaction (OER) is the key to achieving high-performance rechargeable Zn-air batteries. Non-precious-metal single-atom catalysts (SACs) have attracted intense interest due to their low cost and very high metal atomic utilization; however, high-activity bifunctional non-precious-metal SACs are still rare. Herein, we develop a new nanospace-confined sulfur-enamine copolymerization strategy to prepare a new type of bifunctional Mo SACs with O/S co-coordination (Mo-OS-C) supported on the multilayered, hierarchically porous hollow tubes.

Panoramic view of microRNAs in regulating cancer stem cells.

Cancer stem cells (CSCs) are a subgroup of tumor cells, possessing the abilities of self-renewal and generation of heterogeneous tumor cell lineages. They are believed to be responsible for tumor initiation, metastasis, as well as chemoresistance in human malignancies. MicroRNAs (miRNAs) are small noncoding RNAs that play essential roles in various cellular activities including CSC initiation and CSC-related properties.

Filler-Integrated Composite Polymer Electrolyte for Solid-State Lithium Batteries.

Composite polymer electrolytes (CPEs) utilizing fillers as the promoting component bridge the gap between solid polymer electrolytes and inorganic solid electrolytes. The integration of fillers into the polymer matrices is demonstrated as a prevailing strategy to enhance Li-ion transport and assist in constructing Li -conducting electrode-electrolyte interface layer, which addresses the two key barriers of solid-state lithium batteries (SSLBs): low ionic conductivity of electrolyte and high interfacial impedance. Recent review articles have largely focused on the performance of a broad spectrum of CPEs and the general effects of fillers on SSLBs device.

Mesoporous Single Crystals with Fe-Rich Skin for Ultralow Overpotential in Oxygen Evolution Catalysis.

The oxygen evolution reaction (OER) is a key reaction in water splitting and metal-air batteries, and transition metal hydroxides have demonstrated the most electrocatalytic efficiency. Making the hydroxides thinner for more surface commonly fails to increase the active site number, because the real active sites are the edges. Up to now, the overpotentials of most state-of-the-art OER electrocatalysts at a current density of 10 mA cm (η ) are still larger than 200 mV.

Single-Atom Co Doped in Ultrathin WO Arrays for the Enhanced Hydrogen Evolution Reaction in a Wide pH Range.

Owing to the scarcity of Pt, low-cost, stable, and efficient nonprecious metal-based electrocatalysts that can be applied in a wide pH range for the hydrogen evolution reaction (HER) are urgently required. Herein, a highly efficient and robust HER catalyst that is applicable at all pH values is fabricated, containing isolated Co-single atomic sites anchored in the self-supported WO arrays grown on Cu foam. At a current density of 10 mA cm, the HER overpotentials are 117, 105, and 149 mV at pH values of 0, 7, and 14, respectively, which are significantly lower than those of the undoped WO, suggesting superior electrocatalytic H-evolution activity at all pH values.

Prevalence and Related Factors of Depression, Anxiety, Acute Stress, and Insomnia Symptoms Among Medical Staffs Experiencing the Second Wave of COVID-19 Pandemic in Xinjiang, China.

The prevalence and related factors of mental health impact among medical staffs who experienced the second wave of the COVID-19 pandemic in China is unknown. Therefore, this survey was conducted to investigate the prevalence and related factors of depressive, anxiety, acute stress, and insomnia symptoms in medical staffs in Kashi, Xinjiang, China during the second wave of the COVID-19 pandemic. A cross-sectional online survey was conducted among medical staffs working in First People's Hospital of Kashi, Xinjiang.

Loss of miR-192-5p initiates a hyperglycolysis and stemness positive feedback in hepatocellular carcinoma.

Background: Emerging studies revealed that cancer stem cells (CSCs) possessed peculiar metabolic properties, which however remained largely unknown in hepatocellular carcinoma (HCC). Genetic silencing of liver-abundant miR-192-5p was a key feature for multiple groups of CSC-positive HCCs. We thus aimed to investigate essential metabolic features of hepatic CSCs via using HCCs with miR-192-5p silencing as a model.

Hollow Multihole Carbon Bowls: A Stress-Release Structure Design for High-Stability and High-Volumetric-Capacity Potassium-Ion Batteries.

Potassium-ion batteries are potential alternatives to lithium-ion batteries for large-scale energy storage considering the low cost and high abundance of potassium. However, it is challenging to obtain stable electrode materials capable of undergoing long-term potassiation/depotassiation due to the high accumulated stress associated with the huge volume variation of the electrode. Here, we simulate the von Mises stress distributions of four different carbon three-dimensional models under an isotropic initial stress by the finite element method and reveal the critical role of the structure of a hollow multihole bowl on the strain-relaxation behavior.

Occurrence, source, and risk assessment of atmospheric parent polycyclic aromatic hydrocarbons in the coastal cities of the Bohai and Yellow Seas, China.

Parent polycyclic aromatic hydrocarbons (PPAHs) in the ambient air of the coastal cities near the Bohai and Yellow Seas were measured over a full year. The range and geometric average of total PPAH (29 species) were 5.16-1.

Characteristics and human inhalation exposure of ionic per- and polyfluoroalkyl substances (PFASs) in PM of cities around the Bohai Sea: Diurnal variation and effects of heating activity.

Atmospheric PM (particulate matter with aerodynamic diameter <10 μm) samples were collected in the cities along the Bohai Sea Rim during heating and non-heating periods, and ionic per- and polyfluoroalkyl species (PFASs) in the PM were measured. The total concentration of ionic PFASs ranged from 21.8 to 87.

Diffusion of size bidisperse spheres in dense granular shear flow.

Diffusion is an important particle behavior in granular flow. Although granular diffusion has been studied for decades, the diffusion of size bidisperse particles has not been well understood. In this paper, discrete element method simulations with the Lees-Edwards boundary condition are performed to quantify the relation between the diffusion coefficient (D) and flow parameters for size bidisperse spheres in dense granular flow.

Characteristics of perfluoroalkyl acids in atmospheric PM from the coastal cities of the Bohai and Yellow Seas, Northern China.

The concentration distributions, compositional profiles and seasonal variations of 17 perfluoroalkyl acids (PFAAs) in PM (particles with aerodynamic diameters < 10 μm) were determined in seven coastal cities of the Bohai and Yellow Seas. The detection rates of perfluorooctanoic acid (PFOA) and short-chain components (perfluoroalkyl carboxylic acids (PFCAs) with ≤7 carbon atoms and perfluoroalkane sulfonic acids (PFSAs) with ≤5 carbon atoms) were much higher than those of other long-chain PFAA species. The annual average concentration of total PFAAs in PM ranged from 23.

A self-standing silver/crosslinked-poly(vinyl alcohol) network with microfibers, nanowires and nanoparticles and its linear aggregation.

Silver/polymer nanocomposites have made inroads into the fields of electronic devices, thermally conductive materials, antimicrobial agents and sensors. Here, we present the hydrothermal synthesis of a novel three-dimensional self-standing silver/crosslinked-poly(vinyl alcohol) (Ag/crosslinked-PVA) hybrid network constructed by linking three different subunits, namely, microfibers, nanowires and nanoparticles. One-dimensional crosslinked-PVA-based microfibers act as the skeleton of the sponge.

MeCP2 controls hippocampal brain-derived neurotrophic factor expression via homeostatic interactions with microRNA‑132 in rats with depression.

Major depressive disorder (MDD) is a considerable public health concern, which affects patients worldwide. MDD is associated with psychosocial impairment, poor quality of life, and significant disability, morbidity and mortality. Stress is a major factor in depression, which impairs the structural and functional plasticity of the hippocampus.