Therapeutic potential of farnesoid X receptor agonists for modulating inflammation and periodontal regeneration.

Objectives: Inflammation and osteoclast activity are important in various diseases, including periodontitis and osteoporosis. Farnesoid X receptor (FXR) has been identified as a promising target for modulating these processes. This study delved into the impact of FXR agonists on inflammation and periodontal regeneration using periodontitis models.

Photo-methanification of aquatic dissolved organic matters with different origins under aerobic conditions: Non-negligible role of hydroxyl radicals.

Lingering inconsistencies in the global methane (CH) budget and ambiguity in CH sources and sinks triggered efforts to identify new CH formation pathways in natural ecosystems. Herein, we reported a novel mechanism of light-induced generation of hydroxyl radicals (•OH) that drove the production of CH from aquatic dissolved organic matters (DOMs) under ambient conditions. A total of five DOM samples with different origins were applied to examine their potential in photo-methanification production under aerobic conditions, presenting a wide range of CH production rates from 3.

Storages and leaching losses of soil water dissolved CO and NO on typical land use hillslopes in southeastern hilly area of China.

The dynamics of soil water dissolved CO and NO are important in determining the fates of soil CO and NO. However, related mechanisms and processes have been rarely revealed. In this study, storages and leaching losses of soil water dissolved CO and NO were investigated on the tea garden (TG) and bamboo forest (BF) hillslopes.

HSP90AA1 promotes the inflammation in human gingival fibroblasts induced by Porphyromonas gingivalis lipopolysaccharide via regulating of autophagy.

Background: Peri-implantitis of tooth seriously affects the life quality of patients. This study aimed to investigate the role of HSP90AA1 in the inflammatory of human gingival fibroblasts (HGFs) induced by porphyromonas gingivalis lipopolysaccharide (Pg-LPS), and to provide a potential therapeutic target for clinical treatment of peri-implantitis.

Methods: Pg-LPS (0.

Prognosis and predictive value of heat-shock proteins expression in oral cancer: A PRISMA-compliant meta-analysis.

Background: Heat-shock proteins (HSP) is a key chaperone protein which maintains intracellular proteostasis and is expressed on the surface of solid and hematological malignancies. Several studies have reported paradoxical evidence of the association between HSP expression and prognosis of oral cancer. To address the discrepancy, we carried out the meta-analysis to assess the role of HSP such as: HSP70, HSP90, HSP27, HSP60, and HSP105 in susceptibility, progression, and prognosis of oral cancer.

A new type of aortic valved stent with good stability and no influence on coronary artery.

Background: To evaluated the feasibility and safety of new aortic valved stents in transcatheter aortic valve implantation (TAVI) using retrograde approach by in vitro testing and animal implantation.

Materials And Methods: The fluid passing test, expanding and releasing tests, static and releasing tests in tube were performed for new valved stents. Transvalvular pressure gradient, effective orifice area, pre-implantation and post-implantation regurgitant volume for the new stents were detected.

Primary results of chest wall reconstruction with polydioxanone mesh on animals.

Background: With the development of surgical techniques and biomedical material, increasing synthetic materials are applied to the chest wall reconstruction, such as autologous rib, muscle flap, bovine pericardium and sheet metal.

Aim: To detect the safety and efficiency of synthetic material Polydioxanone (PDO) in chest wall reconstruction.

Materials And Methods: Healthy adult mongrel dogs operated with PDO, and then some clinical data were collected.

[Clinical analysis of two-phase treatment of 35 cases with Angle Class II division 1 malocclusion].

Purpose: To evaluate the clinical value of the two-phase treatment of Angle Class II division 1 malocclusion.

Methods: Thirty five cases with Class II division 1 malocclusion were treated with two-phase treatment(Twin-block functional appliance and fixed appliance).Lateral cephalograms were taken before and after treatment for each patient.

Results of radiofrequency ablation for permanent atrial fibrillation in patients undergoing mitral valve surgery.

Objectives: The study aim was to evaluate the safety and feasibility of radiofrequency ablation for the surgical treatment of permanent atrial fibrillation in patients with degenerative mitral valve disease.

Design: From August 2000 to August 2003, 40 consecutive patients (mean age 69.0 +/- 9.

[Effect of the valved stent on closure of patent ductus arteriosus in a miniswine model].

Objective: To evaluate the feasibility of a valved stent on closure patent ductus arteriosus in a Chinese miniswine model.

Methods: Self-expandable nitinol stents were made of Ni-Ti shape memory alloy (9 mm in diameter). Bovine pericardium was shaped and sutured onto the stents.

[Coronary flow obstruction in percutaneous aortic valve replacement using self-expandable valved stent: an in vitro study].

Objective: To study the effects of self-expandable and orthotopically implanted percutaneous aortic valved stent on coronary artery flow in vitro.

Methods: Self-expandable valved stent was developed with nitinol stent and bovine pericardium. The ascending aorta of Chinese mini swine hearts was cut proximal to the brachiocephalic trunk.

PI3K/AKT mediated p53 down-regulation participates in CpG DNA inhibition of spontaneous B cell apoptosis.

The unmethylated CpG DNA can prevent spontaneous apoptosis of B cells. However, the precise mechanisms by which CpG DNA blocks apoptosis remain unclear. In this study, we showed B cell apoptosis was significantly inhibited by addition of CpG DNA.

Transcatheter closure of adult patent ductus arteriosus with severe pulmonary hypertension.

The purpose of this study was to investigate the application of trial balloon occlusion for permanent closure of patent ductus arteriosus (PDA) with severe pulmonary hypertension (PH) in adults, and to assess its immediate and short-term results. From September 1999 to September 2005, a total of ten adults (two males, ages ranging from 20 to 54 years) with PDA who met the criterion for severe PH (basal pulmonary vascular resistance >8 Wood units) received trial balloon occlusion via an embolectomy balloon catheter. Post-occlusion hemodynamics, along with an overall clinical and hemodynamic assessment, was used to consider the indication of closure of PDA.

[Survival after pulmonary metastasectomy: experience in 26 patients].

Background: Surgical resection becomes standard treatment for pulmonary metastatic tumor with operative indication. The aim of this study is to analyze the indication and surgical efficacy of pulmonary metastasectomy.

Methods: From November 1991 to May 2003, a total of 26 patients with pulmonary metastatic tumors were treated surgically in our hospital, 12 cases were males and 14 females, with an average age of 50 years old.

[Combined use of transmyocardial stents with gene therapy in the treatment of acute myocardial infarction].

Objectives: To determine the efficacy of combined use of transmyocardial stent with gene therapy to treat acute myocardial infarction in porcine model.

Methods: 24 Chinese mini swines have been divided into 4 groups randomly: group myocardial infarction (group MI n(1) = 6), group transmyocardial stent (group ST n(2) = 6), group vascular endothelial growth factor (group VEGF n(3) = 6), group transmyocardial stent and VEGF (group ST + VEGF n(4) = 6). In group MI, acute myocardial infarction animal model has been established by the ligation of the left descending coronary artery.