A Novel Inhibitor of Poly(-ibose) Polymerase-1 Inhibits Proliferation of a BRCA-Deficient Breast Cancer Cell Line the DNA amage-ctivated cGAS-STING Pathway.

Loss-of-function mutations in the Breast Cancer Susceptibility Gene (BRCA1 and BRCA2) are often detected in patients with breast cancer. Poly(ADP-ribose) polymerase-1 (PARP1) plays a key role in the repair of DNA strand breaks, and PARP inhibitors have been shown to induce highly selective killing of BRCA1/2-deficient tumor cells, a mechanism termed synthetic lethality. In our previous study, a novel PARP1 inhibitor─()-2-(2,3-dibromo-4,5-dimethoxybenzylidene)--(4-fluorophenyl) hydrazine-1-carbothioamide (4F-DDC)─was synthesized, which significantly inhibited PARP1 activity with an IC value of 82 ± 9 nM.

Proton therapy (PT) combined with concurrent chemotherapy for locally advanced non-small cell lung cancer with negative driver genes.

Purpose: To discuss the optimal treatment modality for inoperable locally advanced Non-Small Cell Lung Cancer patients with poor physical status, impaired cardio-pulmonary function, and negative driver genes, and provide clinical evidence.

Materials And Methods: Retrospective analysis of 62 cases of locally advanced non-small cell lung cancer patients with negative driver genes treated at Tsukuba University Hospital(Japan) and Qingdao University Affiliated Hospital(China).The former received proton therapy with concurrent chemotherapy, referred to as the proton group, with 25 cases included; while the latter underwent X-ray therapy with concurrent chemoradiotherapy followed by 1 year of sequential immunomodulatory maintenance therapy, referred to as the X-ray group, with 37 cases included.

Regulation of Eukaryotic Translation Initiation Factor 4E as a Potential Anticancer Strategy.

Eukaryotic translation initiation factors (eIFs) are highly expressed in cancer cells, especially eIF4E, the central regulatory node driving cancer cell growth and a potential target for anticancer drugs. eIF4E-targeting strategies primarily focus on inhibiting eIF4E synthesis, interfering with eIF4E/eIF4G interactions, and targeting eIF4E phosphorylation and peptide inhibitors. Although some small-molecule inhibitors are in clinical trials, no eIF4E inhibitors are available for clinical use.

Hepatic cavernous hemangioma developed in non-small cell lung cancer patients after receiving Camrelizumab treatment: two case reports.

Purpose: To report two cases of hepatic cavernous hemangioma, a rare complication, in patients with locally advanced and advanced non-squamous non-small cell lung cancer (NSCLC) treated with PD-1 inhibitors. Additionally, to share clinical experiences related to the management of this condition.

Methods: Two patients with locally advanced and advanced non-squamous non-small cell lung cancer (NSCLC) were enrolled in our hospital.

Wide color gamut white light-emitting diodes based on two-dimensional semiconductor nanoplatelets.

II-VI colloidal semiconductor nanoplatelets (NPLs) are a kind of two-dimensional nanomaterial with uniform thickness at the atomic scale, thus leading to the characteristics of tunable emission wavelength and narrow bandwidth. Here, we report wide color gamut white light-emitting diodes (WLEDs) based on high-performance CdSe-based heterostructure NPLs. The narrow-band CdSe/CdS core/crown and CdSe/ZnCdS core/shell NPLs are chosen as green (∼521 nm) and red (∼653 nm) luminescent materials, respectively.

SERS chip fabricated by the thermal effect in a double-metal-cladding waveguide.

Different from ordinary planar waveguide structure, we designed a double-metal-cladding waveguide (DMCW) for easier light coupling into the guiding layer from free space. In contrast to evanescent waves in a surface plasmon polariton waveguide, an oscillating wave is generated in the guiding layer. and a similar Fabry-Perot (FP) cavity can be formed by the DMCW.

Synergistic Combination Chemotherapy of Lung Cancer: Cisplatin and Doxorubicin Conjugated Prodrug Loaded, Glutathione and pH Sensitive Nanocarriers.

Purpose: Prodrug technology-based combination drug therapy has been exploited as a promising treatment strategy to achieve synergistic lung cancer therapy, reduce drug dose, and decrease side effects. In the present study, we synthesized a pH and glutathione (GSH) sensitive prodrug, cisplatin (CIS) and doxorubicin (DOX) conjugates (CIS-DOXp). CIS-DOXp was loaded by nanocarriers and delivered into the tumor site.

LncRNA TTN-AS1 Regulates miR-524-5p and RRM2 to Promote Breast Cancer Progression.

Background: Recent studies suggest many long non-coding RNAs (lncRNAs) are crucial oncogenes or tumor suppressors. This study intended to investigate the biological function and mechanism of lncRNA TTN antisense RNA 1 (TTN-AS1) in the progression of breast cancer (BC).

Materials And Methods: BC tissue samples were collected.

CircRNA_100876 sponges miR-136 to promote proliferation and metastasis of gastric cancer by upregulating MIEN1 expression.

Previous reports have revealed that circRNA_100876 was extremely important in the progression of triple-negative breast cancer. Nevertheless, the mechanism towards the role of circRNA_100876 in Gastric cancer (GC) remains unknown. Here, we determined circRNA_100876 expression by quantitative real-time PCR (qRT-PCR) in twenty pairs of GC tissues and adjacent tissues.

miR-199a-5p is involved in doxorubicin resistance of non-small cell lung cancer (NSCLC) cells.

Non-small cell lung cancer (NSCLC) is one of the prevalent and deadly cancers worldwide. Chemotherapy resistance is one of the most challenging problems for NSCLC and other cancer treatment. Recent study suggested that miRNAs are involved in therapeutic functions of chemotherapy during cancer treatment.

Wigg. Attenuates Inflammatory Responses in Murine Microglia through the Nrf2/HO-1 and NF-B Signaling Pathways.

As a long-established medicinal and edible homologous plant, Wigg. is widely distributed in Asia, Europe, and other parts of the world. is reported to exert a variety of biological and pharmacological activities, including anticancer, hepatoprotective, and anti-obesity effects.

Targeting survivin sensitizes cervical cancer cells to radiation treatment.

Survivin is an inhibitor of apoptosis protein that functions to inhibit apoptosis, promote proliferation, and enhance invasion. It is selectively up-regulated in many human tumors and implicated in cellular radiation response through its role in apoptosis, cell division, and DNA damage response. This study aimed to investigate the effect and mechanisms of targeting survivin radiosensitivity in cervical cancer C33A cells.

FGF10 Enhances Peripheral Nerve Regeneration the Preactivation of the PI3K/Akt Signaling-Mediated Antioxidant Response.

The process of axonal regeneration after peripheral nerve injury (PNI) is slow and mostly incomplete. Previous studies have investigated the neuroprotective effects of fibroblast growth factor 10 (FGF10) against spinal cord injury and cerebral ischemia brain injury. However, the role of FGF10 in peripheral nerve regeneration remains unknown.

Butein inhibits IL-1β-induced inflammatory response in human osteoarthritis chondrocytes and slows the progression of osteoarthritis in mice.

Osteoarthritis (OA) is a progressive degenerative disease characterized by irreversible articular cartilage destruction. Butein, a polyphenolic compound isolated from the stem bark of cashews and Rhus verniciflua Stokes, has been reported to have anti-inflammatory effects. This study aimed to assess the effect of butein on human OA chondrocytes and mice OA models induced by destabilization of the medial meniscus (DMM).

Refractive index modulating Raman spectroscopy based on perovskite PMN-PT ceramics.

A three-layer planar waveguide structure comprising a perovskite (1-x)Pb(MgNbNb)OPbTiO (PMN-PT) ceramic sandwiched by two silver films is designed and called PMPW. Using the high sensitivity of ultrahigh-order modes, theoretical analysis is performed to calculate the effective refractive index (ERI) of the PMPW. A detailed analysis of the Raman spectrum of PMN-PT at 795  cm is performed.

Multifunctional Nanocomposite with Magnetism, Thermosensitivity and Surface Enhanced Raman Scattering Effect.

Multifunctional Fe3O4 @poly(N-isopropylacrylamide-co-acrylamide), Au (Fe3O4 @PNIPAM-AAM, Au) composite with magnetism, themosensitivity, surface enhanced Raman scattering (SERS) effect and drug delivery ability was successfully prepared. Transmittance measurements at 350 nm confirm the composite has a lower critical solution temperature (LCST) about 41 degrees C. Due to the network structure of PNIPAM-AAM, the composite is also an ideal drug carrier.

Study of circulating IgG antibodies to peptide antigens derived from BIRC5 and MYC in cervical cancer.

The present study was undertaken to detect circulating IgG antibodies to peptide antigens derived from baculoviral IAP repeat-containing protein 5 isoform 2 (BIRC5) and myc proto-oncogene protein (MYC) in cervical cancer. A total of 107 female patients with cervical cancer of stages I and II, and 130 healthy female subjects were recruited for analysis of circulating IgG antibodies to BIRC5 and MYC. Student's t-test showed significant differences in circulating levels of anti-BIRC5 IgG (t = -4.

Glucosamine protects nucleus pulposus cells and induces autophagy via the mTOR-dependent pathway.

Although glucosamine has been suggested to be effective in the treatment of osteoarthritis, its effect on disc degeneration remains unclear. We sought to explore whether glucosamine can activate autophagy in rat nucleus pulposus (NP) cells and protect cells treated with IL-1β or hydrogen peroxide (H2 O2 ). Autophagy in cells was examined by detecting for LC3, Beclin-1, m-TOR, and p70S6K, as well as by analyzing autophagosomes.

Anti-p16 autoantibodies may be a useful biomarker for early diagnosis of esophageal cancer.

Aim: Our recent work suggested that circulating IgG antibodies to a linear peptide derived from p16 protein were significantly increased in patients with lung cancer. The present study was then designed to test whether such autoantibodies were also altered in esophageal cancer.

Methods: An enzyme-linked immunosorbent assay was developed in-house to determine circulating IgA and IgG antibodies against p16 protein-derived antigens in 97 patients with esophageal squamous cell carcinoma (ESCC) and 226 healthy subjects.