Preparation, Crystal Structure, and Properties of the Kagome Metal ThVSn.

Kagome lattice materials are anticipated to exhibit unique properties stemming from the intricate interplay among geometry, magnetism, electronic correlation, and band topology. Here, we report a new ternary compound, ThVSn, which contains double-layer kagome networks composed of vanadium atoms. The compound crystallizes in an HfFeGe-type structure with cell parameters of = = 5.

The dynamic patterns of metabolic-associated fatty liver disease and its severity and risk of cardiovascular disease.

Background: While metabolic-associated fatty liver disease (MAFLD) is widely recognized as a risk factor for cardiovascular disease (CVD), the connection between the dynamic patterns of severity of hepatic steatosis and the associated CVD risk remains uncertain.

Method: This study included 71,098 participants from the Kailuan Study without CVD or cancer who underwent two consecutive biennial health screenings between 2006 and 2008 and were followed up until 2022. MAFLD and its severity were assessed using ultrasound.

Optimized agricultural management reduces global cropland nitrogen losses to air and water.

Nitrogen (N) losses from croplands substantially contribute to global N pollution. Assessing the reduction in N losses through improved N management practices is complex due to varying site conditions, such as land use, climate, soil properties and local farming methods. In this Article, we conducted a meta-analysis to evaluate the effects of improved practices on N loss reduction, analysing data from 1,065 studies with 6,753 pairs of observations comparing standard and optimized practices.

Astragaloside Ⅳ mediates the effect and mechanism of KPNB1 on biological behavior and tumor growth in prostate cancer.

Background: and purpose Prostate cancer is an comparatively prevalent clinical malignant tumor in men, impacting the lives of millions of men globally. This study measured the expression of Karyopherin Subunit Beta 1 (KPNB1) in prostate cancer cells, and made an effort to investigate how astragaloside IV affects the biological behavior, tumor growth, and mechanism of action of prostate cancer through KPNB1.

Methods: Human prostate cancer and normal cells were obtained and KPNB1 expression levels in the two cells were determined using qPCR and WB.

RC48-Antibody-Drug Conjugate in Metastatic Urothelial Carcinoma: A Multicenter Real-World Study in China.

Objectives: RC48 is an antibody-drug conjugate (ADC) that targets HER2. In China, RC48 is approved for patients with HER-2-positive metastatic urothelial carcinoma (mUC) who have failed at least platinum-based chemotherapy. This study aimed to evaluate RC48 for mUC in a cohort of real-world patients.

Cryogenic Thermal Shock Effects on Optical Properties of Quantum Emitters in Hexagonal Boron Nitride.

Solid-state quantum emitters are vital building blocks for quantum information science and quantum technology. Among various types of solid-state emitters discovered to date, color centers in hexagonal boron nitride have garnered tremendous traction in recent years, thanks to their environmental robustness, high brightness, and room-temperature operation. Most recently, these quantum emitters have been employed for satellite-based quantum key distribution.

Paired-Related Homeobox 1-Positive Cells Are Needed for Osseointegration.

Purpose: To explore the contribution of paired-related homeobox 1-positive (Prrx1+) cells to the implant-induced osseointegration process in adult alveolar bone and the potential underlying mechanisms.

Materials And Methods: Crerecombinase-induced lineage tracing and cell ablation were conducted in a murine dental implant model. Scratch and transwell assays were used to assess MC3T3-E1 cell migration after paired-related homeobox 1 overexpression.

Superconductivity and Charge-Density-Wave-Like Transition in ThCuAs.

We report the synthesis, crystal structure, and physical properties of a novel ternary compound, ThCuAs. The material crystallizes in a tetragonal structure with lattice parameters = 4.0639(3) Å and = 24.

Leptin receptor (+) stromal cells respond to periodontitis and attenuate alveolar bone repair via CCRL2-mediated Wnt inhibition.

The impaired bone healing in tooth extraction sockets due to periodontitis presents a major obstacle to restoring oral health. The mechanisms regulating the osteogenic capacity of jawbone-derived stromal cells in the periodontitis microenvironment remain elusive. Leptin receptor (LepR) expressing stromal cells, which largely overlap with Cxcl12-abundant reticular (CAR) cells in bone tissue, rapidly proliferate and differentiate into bone-forming cells during extraction socket healing to support alveolar bone repair.

Wettability and Mechanical Properties of Red Mud-AlO Composites.

In 2023, the global production of new red mud is expected to reach nearly 200 million tons, but less than 10% of it is currently being utilized in an environmentally friendly manner. To reduce the sintering temperature of alumina ceramics, a sintering aid method is used, as high-purity alumina ceramics require a solid-phase sintering temperature of over 1700 °C. The metal oxides present in red mud are necessary components for high-performance composite alumina ceramics.

One-time relieving of frozen shoulder motor dysfunction with pure acupotomy: A case report.

Background: Frozen shoulder (FS) is characterized by shoulder pain and restricted movement of the shoulder joint. While it tends to resolve on its own, it significantly affects an individual quality of daily life. The pure acupotomy technique employs needle-knife manipulation as the sole treatment, without the use of medications, such as steroids or vitamins, and local anesthesia if necessary.

Acupuncture and sleep disorders in Parkinson's disease: A systematic evaluation with meta-analysis.

Background: Parkinson's disease (PD) patients commonly suffer from sleep disorders, significantly impacting their quality of life. Western treatments often entail adverse effects, while acupuncture (ACU) presents a safe, nonaddictive alternative.

Methods: A thorough literature search was performed across PubMed, Cochrane Library, and Embase databases.

ThCrSiC: An Antiferromagnetic Metal with a CrC Square Lattice.

A quaternary compound, ThCrSiC, was synthesized by using the arc-melting technique. The compound adopts a tetragonal CeCrSiC-type crystal structure. The electronic resistivity and specific heat data exhibit metallic behavior, while the magnetic susceptibility displays a pronounced broad peak at around 370 K, indicating the antiferromagnetic phase transition.

Optimizing cropping systems to close the gap between economic profitability and environmental health.

Supporting food security while maintaining ecosystem sustainability is one of the most important global challenges for humanity. Optimization of cropping systems is expected to promote the ecosystem services of agroecosystems. Yet, how and why cropping system influences the trade-offs between economic profitability and multiple ecosystem services remain poorly understood.

Full substitution of chemical fertilizer by organic manure decreases soil N O emissions driven by ammonia oxidizers and gross nitrogen transformations.

Replacing synthetic fertilizer by organic manure has been shown to reduce emissions of nitrous oxide (N O), but the specific roles of ammonia oxidizing microorganisms and gross nitrogen (N) transformation in regulating N O remain unclear. Here, we examined the effect of completely replacing chemical fertilizer with organic manure on N O emissions, ammonia oxidizers, gross N transformation rates using a 13-year field manipulation experiment. Our results showed that organic manure reduced cumulative N O emissions by 16.

Global mean nitrogen recovery efficiency in croplands can be enhanced by optimal nutrient, crop and soil management practices.

An increase in nitrogen (N) recovery efficiency, also denoted as N use efficiency (NUEr), is crucial to reconcile food production and environmental health. This study assessed the effects of nutrient, crop and soil management on NUEr accounting for its dependency on site conditions, including mean annual temperature and precipitation, soil organic carbon, clay and pH, by meta-regression models using 2436 pairs of observations from 407 primary studies. Nutrient management increased NUEr by 3.

Spatial variation in actual and required nitrogen use efficiency and the potential to close the gap by management practices.

To boost crop production, China uses almost a third of the world's nitrogen (N) fertilizer. However, N losses due to enhanced application of N fertilizers has led to surface water and groundwater pollution. A reduction in N losses without reducing crop yields is possible by increasing nitrogen use efficiency (NUE), which is important for the effective management of local crop production and water quality.

Targeted inhibition of mTOR by BML-275 induces mitochondrial-mediated apoptosis and autophagy in prostate cancer.

Prostate cancer (PCa) is the most frequently diagnosed cancer among men and the second leading cause of death in Western countries. Clinically, screening drugs and develop developing new therapeutics to treat PCa is of great significance. In this study, BML-275 was demonstrated to exert potent antitumor effects in PCa by antagonizing mTOR activity.

SARS-CoV-2 Vaccine Uptake among Patients with Chronic Liver Disease: A Cross-Sectional Analysis in Hebei Province, China.

Chronic liver disease (CLD) patients have higher mortality and hospitalization rates after infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This study aimed to explore SARS-CoV-2 vaccine perceptions, side effects, factors associated with nonvaccination and attitudes toward fourth-dose vaccine among CLD patients. The differences between vaccinated and unvaccinated groups among 1491 CLD patients and the risk factors associated with nonvaccination status were analyzed.

Identification of crucial genes related to heart failure based on GEO database.

Background: The molecular biological mechanisms underlying heart failure (HF) remain poorly understood. Therefore, it is imperative to use innovative approaches, such as high-throughput sequencing and artificial intelligence, to investigate the pathogenesis, diagnosis, and potential treatment of HF.

Methods: First, we initially screened Two data sets (GSE3586 and GSE5406) from the GEO database containing HF and control samples from the GEO database to establish the Train group, and selected another dataset (GSE57345) to construct the Test group for verification.