Publications by authors named "Yong-xia Liu"
Background And Aims: Multiple studies have shown that hepatic fibrosis, a progressive condition that represents the endpoint of various chronic liver diseases, is primarily marked by the extensive activation of hepatic stellate cells (HSCs). However, the exact impact of cystic fibrosis transmembrane conductance regulator (CFTR) on HSCs during the development of hepatic fibrosis remains unclear.
Methods: In our study, we measured CFTR levels in tissue samples and in HSCs activated by TGF-β stimulation.
Genes associated with induced pluripotent stem cells (iPS genes) are several pivotal transcriptional factors, which are used to induce pluripotent stem cells from some adult somatic cells. The roles of these iPS genes and especially the signature for these iPS genes in colorectal cancer (CRC) are still unclear. Overexpressed Oct4 and Lin28 but down-regulated Nanog were found in tumor tissues compared with that in their paired normal counterparts of CRC patients.
View Article and Find Full Text PDFThe regulators of a key metastasis gene PRL-3 in colorectal cancer (CRC) are still largely unknown. We found three potential binding sites of Snail, a key transcriptional factor involved in the epithelial-mesenchymal transition (EMT), in the region of PRL-3 promoter (located at -642 to -383). Moreover, our results showed that one of the Snail binding sites (located at -624 to -619) was the key element to maintain promoter activity of human PRL-3 gene.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to identify and understand the role of microRNAs (miRNAs) in urothelial bladder cancer (BCa) among the Chinese population, extending the existing knowledge on tumorigenesis.
- Researchers used laser capture microdissection to extract tumor cells from 20 BCa samples and compared them with normal bladder epithelial controls, analyzing RNA through advanced sequencing technology.
- Findings revealed significant differences in miRNA expression between BCa and normal samples, identifying 74 differently expressed miRNAs and predicting 13 novel miRNAs, enhancing the understanding of miRNA involvement in bladder cancer.
To better understand the role of PRL-3 in progression and metastasis of colorectal cancer (CRC), we searched for PRL-3 associated proteins using proteomic methods. We identified 39 PRL-3 associated proteins based on proteomic strategy. Stathmin, a key oncoprotein, was proved to be a new PRL-3 associated protein.
View Article and Find Full Text PDF[Brain impairment induced by oral intake of lead and its effects on expression of Hoxa9 Gen in Rats].
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi
October 2006
Objective: To observe effects of oral intake of lead on the expression of Hoxa9 gen and the ability of learning and memory and explore the the toxic molecular mechanisms of lead.
Methods: Thirty male Wistar rats were chosen and randomly divided into the low lead dosage group, the high lead dosage group and the control group, 10 rats in each group. The low lead dosage group and the high lead dosage group were given respectively 0.