Analysis of an extended chromosome locus 2p14-21 for replication of the 2p16.3 association with glaucoma susceptibility.

Purpose: Susceptibility to primary open-angle glaucoma (POAG) has recently associated with three intergenic single-nucleotide polymorphisms (SNPs) on human chromosome 2p16.3, just outside of the POAG-linkage locus GLC1H (2p15-16.2), in an Afro-Caribbean population.

Isolated abducens nerve palsy in a patient with scrub typhus.

Abducens nerve palsies associated with infectious diseases are infrequent. Scrub typhus is an acute, febrile, infectious illness caused by Orientia tsutsugamushi (formerly Rickettsia tsutsugamushi), an obligate-intracellular gram-negative bacterium. The organism has been reported to be capable of entering the nervous system, causing meningitis and focal neurologic abnormalities.

Changes in macular thickness after panretinal photocoagulation in patients with severe diabetic retinopathy and no macular edema.

Purpose: The purpose of this study was to investigate changes in macular thickness after panretinal photocoagulation (PRP) in patients with severe diabetic retinopathy (DR) without macular edema and to compare the visual acuity outcomes.

Methods: This prospective cohort study included 30 patients with severe nonproliferative DR or non-high-risk proliferative DR whose visual acuity was > or =0.8 before PRP.

Changes in corneal endothelial cells after Ahmed glaucoma valve implantation: 2-year follow-up.

Purpose: To evaluate changes in corneal endothelial cells after Ahmed glaucoma valve (AGV) implantation for the treatment of refractory glaucoma.

Design: Observational case series.

Methods: We prospectively evaluated the change in density and shape of the corneal endothelium in 41 patients (41 eyes) who had undergone AGV implantation for the treatment of refractory glaucoma.