Bioinformatics Identification of angiogenesis-related biomarkers and therapeutic targets in cerebral ischemia-reperfusion.

Promoting vascular endothelial cell regeneration can enhance recovery from cerebral ischemia reperfusion injury (CIRI), but there is a lack of bioinformatic studies on angiogenesis-related biomarkers in CIRI. In this study, we utilized the GSE97537 and GSE61616 datasets from GEO to identify 181 angiogenesis-related genes (ARGs) and analyzed differentially expressed genes (DEGs) between CIRI and control groups. We converted ARGs to 169 rat homologues and intersected them with DEGs to find DE-ARGs.

Tanshinone IIA improves sepsis-induced acute lung injury through the ROCK2/NF-κB axis.

Background: This research sought to explore the effects of Tanshinone IIA (TIIA) and its potential mechanism in sepsis-induced acute lung injury.

Methods: Cecal ligation and puncture (CLP) was performed to construct a sepsis model in vivo. RLE-6TN cells were treated with lipopolysaccharide (LPS) to establish a sepsis model for in vitro experiments.

Microbial keystone taxa drive crop productivity through shifting aboveground-belowground mineral element flows.

Unbalanced fertilization of nutritional elements is a potential threat to environmental quality and agricultural productivity in acid soil. Harnessing keystone taxa in soil microbiome represents a promising strategy to enhance crop productivity as well as reducing the adverse environmental effects of fertilizers, with the goal of agricultural sustainability. However, there is a lack of information on which and how soil microbial keystone taxa contribute to sustainable crop productivity in acid soil.

Chinese Herbal Medicine Alleviates Myocardial Ischemia/Reperfusion Injury by Regulating Endoplasmic Reticulum Stress.

Myocardial ischemia/reperfusion injury is the main cause of increased mortality and disability in cardiovascular diseases. The injury involves many pathological processes, such as oxidative stress, calcium homeostasis imbalance, inflammation, and energy metabolism disorders, and these pathological stimuli can activate endoplasmic reticulum stress. In the early stage of ischemia, endoplasmic reticulum stress alleviates the injury as an adaptive survival response, but the long-term stress on endoplasmic reticulum amplifies oxidative stress, inflammation, and calcium overload to accelerate cell damage and apoptosis.

[Expression Level and Target Gene Prediction of miR-181b in Patients with Chronic Lymphocytic Leukemia].

Objective: To analyze the diagnostic value of multiple reverse transcription-polymerase chain reaction (RT-PCR) for detecting different fusion genes in children with primary acute lymphoblastic leukemia (ALL).

Methods: The clinical data of 80 children with ALL treated in the 2 affiliated hospital of Xi'an Medical College from September 2012 to September 2017 were collected and retrospectively analyzed. Immunophenotype, chromosome karyotype and fusion gene were analyzed.

Requirement of Rab21 in LPS-induced TLR4 signaling and pro-inflammatory responses in macrophages and monocytes.

Lipopolysaccharide (LPS) induces macrophage/monocyte activation and pro-inflammatory cytokines production by activating Toll-like receptor 4 (TLR-4) signaling. Rab GTPase 21 (Rab21) is a member of the Rab GTPase subfamily. In the present study, we show that LPS induced TLR4 and Rab21 association and endosomal translocation in murine bone marrow-derived macrophages (BMDMs) and primary human peripheral blood mononuclear cells (PBMCs).

GSK621 activates AMPK signaling to inhibit LPS-induced TNFα production.

LPS stimulation in macrophages/monocytes induces TNFα production. We here tested the potential effect of GSK621, a novel AMP-activated protein kinase (AMPK) activator, against the process. In RAW264.

Quantized stabilization of wireless networked control systems with packet losses.

This paper considers stabilization of discrete-time linear systems, where wireless networks exist for transmitting the sensor and controller information. Based on Markov jump systems, we show that the coarsest quantizer that stabilizes the WNCS is logarithmic in the sense of mean square quadratic stability and the stabilization of this system can be transformed into the robust stabilization of an equivalent uncertain system. Moreover, a method of optimal quantizer/controller design in terms of linear matrix inequality is presented.

[Distribution of Redox Zone at Different Water Layers in the Presence of Periphyton and the Responsible Microorganisms].

So far, many types of carriers (such as artificial mat, industrial soft carriers) have been widely used in removing pollutants, purifying water quality via the periphyton attached on the surface of these carriers. In the presence of periphyton, the distribution of redox zone at different water layers is directly or indirectly associated with the removal rate of pollutants. Therefore, it is more practically significant to study the distribution of redox zone at different water layers and the microbial diversity in the presence of periphyton.

Stop and restart of granular clock in a vibrated compartmentalized bidisperse granular system.

This paper studies a bidisperse granular mixture consisting of two species of stainless steel spheres in a vertically vibrated compartmentalized container. The experiments show that with proper vibration acceleration, the granular clock stops when horizontal segregation of the large spheres residing in the far end from the barrier wall occurs. When the segregation is broken, the granular clock restarts.

Effect of branchings on blood flow in the system of human coronary arteries.

In this work, we investigate the behavior of the pulsatile blood flow in the system of human coronary arteries. Blood is modeled as an incompressible non-Newtonian fluid. The transient phenomena of blood flow through the coronary system are simulated by solving the three dimensional unsteady state Navier-Stokes equations and continuity equation.

Effects of formoterol-budesonide on airway remodeling in patients with moderate asthma.

Aim: To evaluate the effect of inhaled formoterol-budesonide on airway remodeling in adult patients with moderate asthma.

Methods: Thirty asthmatic patients and thirty control subjects were enrolled. Asthmatic subjects used inhaled Symbicort 4.

[The clinical significance of noninvasive inflammatory markers in exhaled breath condensate and induced sputum in persistent asthmatic patients].

Objective: To assess the clinical significance of three different noninvasive airway inflammatory indices in induced sputum and exhaled breath condensate (EBC) from persistent asthmatic patients.

Methods: Moderate and severe asthmatic patients were prescribed inhaled corticosteroids combined with long-acting beta(2) agonists for a month. The symptom scores and percentage of predicted value of forced expiratory volume in one second (FEV(1)) (FEV(1)%pred) were measured while the concentrations of H(2)O(2), NO(3)(-)/NO(2)(-), and cysteinyl-leukotriene E(4) (LTE(4)) in induced sputum and EBC were detected before and after therapy.

Dynamical hysteresis phenomena in complex network traffic.

In this Brief Report, the dynamical hysteresis is investigated in constant-density traffic system of scale-free, small-world, and lattice networks. With the local-searching strategy, hysteresis persists for scale-free networks, while it disappears for small-world networks and lattice grids when the handling ability of nodes is higher than a certain threshold. With the shortest-path-routing strategy, hysteresis persists for all three networks investigated.

[The relevance of leukotriene C(4) synthase gene A (-444) C polymorphism to clinical responsiveness to montelukast in patients with asthma].

Objective: To investigate the frequency of leukotriene C(4) synthase gene A (LTC(4)S A) -444 C polymorphism in asthmatics of Chinese Han nationality in Southwest China and to evaluate its relevance to clinical responsiveness to leukotriene receptor antagonist.

Methods: A hundred and fifty asthmatics and 146 healthy blood donors were recruited. The genotype distribution of A/C polymorphism of LTC(4)S A(-444)C gene was analyzed by RELP (restriction fragment length polymorphism).

Spatial three-player prisoners' dilemma.

This paper extends traditional two-player prisoners' dilemma (PD) to three-player PD. We have studied spatial patterns of cooperation behaviors, growth patterns of cooperator clusters and defector clusters, and cooperation frequency of the players. It is found while three-player PD exhibits many properties similar to two-player PD, some new features arise.

Weak and strong coupling in a two-lane asymmetric exclusion process.

This paper studies a two-lane totally asymmetric simple exclusion process, in which particles could jump between the two lanes with asymmetric rates. In the weak coupling situation, the rates are inversely proportional to system size L . The appearance of localized shock in one lane and the discontinuous phase transition as revealed by Juhász [Phys.

Budesonide/formoterol decreases expression of vascular endothelial growth factor (VEGF) and VEGF receptor 1 within airway remodelling in asthma.

Introduction: Angiogenesis and microvascular remodelling may play a vital role in the chronic inflammatory process within asthma. One of the most important factors involved in angiogenesis is vascular endothelial growth factor (VEGF). In this study we hypothesised that an increased expression of VEGF may be involved in airway remodelling in asthma patients.

Phase transition and hysteresis in scale-free network traffic.

We model information traffic on scale-free networks by introducing the node queue length L proportional to the node degree and its delivering ability C proportional to L . The simulation gives the overall capacity of the traffic system, which is quantified by a phase transition from free flow to congestion. It is found that the maximal capacity of the system results from the case of the local routing coefficient phi slightly larger than zero, and we provide an analysis for the optimal value of phi.

[Chemical characteristics of nitrogen and phosphorus in the sediments of the typical bays in Dianchi Lake and calculation of their dredging layers].

The sediments of Haidong bay and Macun bay in Dianchi Lakes' experimental area were studied. The sediment column was cut in every 3cm, and the following items are tested, such as total phosphorus, phosphorus species, which include labile phosphate, Fe,Al-P, Ca-P and residual-P, total nitrogen, nitrate nitrogen, nitrite nitrogen, ammonium nitrogen. The results showed that the loads of nitrogen and phosphorus of these two bays increased quickly in recent years.

[Method of algae-bacterium biofilm to improve the water quality in eutrophic waters].

The quality of eutrophic waters was improved by the algae-bacterium biofilm, which covered over the artificial aquatic mat made from a kind of mend macromolecule material. Two series of experiments show that using the artificial aquatic mat technique, algae bloom was inhibited markedly. At the eleventh day, the transparency was increased from 6 cm to 62 cm; and the concentrations of COD(Mn), TP, TN and NH4(+) -N were decreased to 92.