Publications by authors named "Yong-hao Hu"
During our collecting trip to Guangxi in 2016, we collected ten specimens of the genus from the suburb of Guilin, northeastern Guangxi, South China, and found that they did not belong to any currently known species. Here, we described this new species, sp. nov.
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- Allograft rejection is a significant challenge in organ transplantation, and this study investigates the effects of recombinant human IL-37 (rhIL-37) in improving graft survival in a mouse model.
- The research found that rhIL-37 treatment led to long-term acceptance of transplanted hearts by reducing immune cell infiltration and modulating cytokine profiles, specifically increasing Treg cells and decreasing inflammatory cytokines like TNF-α.
- The findings suggest that IL-37 may be a promising therapeutic option for preventing organ rejection, highlighting its role in immune regulation through pathways like p-mTOR.
Article Synopsis
- * Researchers used gene data from RA patients to identify differentially expressed genes compared to healthy individuals, linking these to the potential effectiveness of the ointment's ingredients derived from Chinese medicine databases.
- * The findings suggest that the medicine targets various biological functions, particularly in immune responses, nervous system operations, and metabolism, with different ingredient groups addressing specific health concerns like inflammation and nerve agitation.
Article Synopsis
- Chicken colibacillosis poses a significant threat to the poultry industry, with ceftiofur sodium commonly used for treatment amidst lipopolysaccharide accumulation.
- Previous studies indicated that polysaccharides from charred Angelica sinensis (CASP) provide better liver protection than those from unprocessed sources (UASP), although the exact mechanisms remained unclear.
- This research utilized advanced techniques to identify 12 disrupted metabolic pathways and highlighted that CASP's protective effects are linked to the arachidonic acid metabolism and mTOR signaling pathways, while UASP mainly relates to the arachidonic acid metabolism pathway.
Oxymatrine protects cardiac allografts by regulating immunotolerant cells.
Int Immunopharmacol
November 2021
Organ transplantation is an effective treatment strategy for patients with irreversible organ failure or congenital organ dysfunction. Oxymatrine (OMT) is a quinolizidine alkaloid with protective and anti-inflammatory effects on tissues and organs. The objective of this study was to investigate whether OMT could exert protective effects in cardiac allografts by regulating immune cells.
View Article and Find Full Text PDFInfluenza is an acute respiratory infection caused by the influenza virus, and vaccination against influenza is considered the best way to prevent the onset and spread. MDCK (Madin-Darby canine kidney) cells are typically used to isolate the influenza virus, however, their high tumorigenicity is the main controversy in the production of influenza vaccines. Here, MDCK-C09 and MDCK-C35 monoclonal cell lines were established, which were proven to be low in tumorigenicity.
View Article and Find Full Text PDFTo evaluate and compare the short-term outcomes of robotic surgery and laparoscopic approach in distal pancreatectomy (DP). EMBASE, PubMed, the Cochrane Library, CNKI and Wan Fang database were retrieved from the inception of electronic databases to June 2019. All analyses were performed using Stata/SE 15.
View Article and Find Full Text PDFBackground: Echinococcus multilocularis causes alveolar echinococcosis (AE) and is widely prevalent in Qinghai Province, China, where a number of different species have been identified as hosts. However, limited information is available on the Qinghai vole (Lasiopodomys fuscus), which is hyper endemic to Qinghai Province and may represent a potential intermediate host of E. multilocularis.
View Article and Find Full Text PDFBackground: Plectasin might serve as a substitute for traditional antibiotics, but its yields and antimicrobial activities warrant further investigation.
Objective: To identify the influence of inducible versus constitutive expression of plectasin on yields and antimicrobial activities.
Methods: Through SOE-PCR, a recombinant plectasin gene was generated and inserted into inducible (pPICZαA) and constitutive (pGAPZαA) vectors in order to create Pichia pastoris GS115 strains.
Aim: To identify the gene (s) related to the antagonistic activity of Enterobacter cloacae B8 and to elucidate its antagonistic mechanism.
Methods: Transposon-mediated mutagenesis and tagging method and cassette PCR-based chromosomal walking method were adopted to isolate the mutant strain(s) of B8 that lost the antagonistic activity and to clone DNA fragments around Tn5 insertion site. Sequence compiling and open reading frame (ORF) finding were done with DNAStar program and homologous sequence and conserved domain searches were performed with BlastN or BlastP programs at www.