Publications by authors named "Yong-guo Huang"
Article Synopsis
- Hepatitis B virus (HBV) remains a significant public health issue, particularly in China, prompting a study to assess its epidemiological and clinical characteristics in children to help control its spread in Wuhan.
- A retrospective analysis of over 115,000 children aged 0-18 revealed overall low positive detection rates for various HBV serological markers, with notable differences in results between males and females.
- The study identified 22 distinct HBV serological expression patterns, with the majority being more common among neonatal patients, while the overall detection rate showed a decline over the analyzed four years.
[Preparation of anti HBs monoclonal antibody and its combination characterization to both wild-type HBsAg and immune escape mutant HBsAg].
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi
June 2008
Aim: To prepare monoclonal antibodies against HBsAg and estimate its binding capacity to both wild-type and varies of immune escape mutant-type HBsAg.
Methods: Using self-made the anti-HBs G6 mAb and HRP-labeled goat anti-HBs antibody, A sandwich ELISA for detection both wild-type and varies of immune escape mutant-type HBsAg has been developed. Applying this assay, to detect 17 species of whole gene wild-type and recombination expressed HBsAg which varied in "a" determinant.