Publications by authors named "Yong-en Gu"
[Evidence-based study of chromate exposed workers' health surveillance indexes].
Zhonghua Yu Fang Yi Xue Za Zhi
September 2013
Objective: The health surveillance proposal for chromate exposed workers was provided and analyzed on the evidence-based study and then to be improved.
Method: Firstly, the related literatures were searched about liver damage, micronuclei, urinary chromium and hexavalent chromium exposure in Evidence Based Medicine Reviews such as Cochran library, OVID Medline, Web of knowledge in December 2011; and then, these literatures were reviewed in according to inclusion and exclusion criteria; 22 articles totally were retrieved, evaluated and classified in according to the grading standard by Oxford Centre for Evidence-based Medicine.Finally, field epidemiological investigation was further adopted to confirm the efficiency and feasibility of this proposal, combined with cost-effectiveness analysis:the ratio of total cost divided survival years was used to express the cost-effectiveness.
Both hexavalent chromium [Cr (VI)] exposure and folate deficiency have been associated with increased cancer risks. Our previous studies have found folate deficiency in Cr (VI) exposed population. Here the relationship between some tumor markers and folate status in long-term Cr (VI) exposure was investigated carefully to show the multiple aspects of Cr (VI) carcinogenesis.
View Article and Find Full Text PDF[Impact of specimen collection and storage consumable products on trace element quantitative analysis].
Zhonghua Yu Fang Yi Xue Za Zhi
July 2012
Article Synopsis
- The study investigated how different brands of specimen collection and storage products affect the accuracy of trace element analysis in samples.
- Various collection devices and consumables were tested for their potential contamination by elements like cadmium, copper, and zinc using advanced measurement techniques.
- Results showed varying levels of background element concentrations, with some brands exhibiting higher contamination, particularly in urine and blood sampling devices, which could impact the reliability of test results.
[Dynamic observation of pulmonary ventilation function in workers contacting chromate].
Beijing Da Xue Xue Bao Yi Xue Ban
June 2012
Article Synopsis
- The study aimed to investigate the impact of chronic chromate exposure on the pulmonary ventilation function of workers in a chromate manufacturing factory in Henan Province, comparing them to a control group without exposure.
- Results from 2010 and 2011 showed significant decreases in vital lung function measurements (like FVC and FEV1) among the chromate-exposed workers compared to the control group, indicating negative effects on respiratory health.
- Despite the observed declines, the classification of pulmonary dysfunction among both groups remained similar, primarily categorized as "limit type," suggesting that the extent of dysfunction didn't change significantly over the exposure period.
Article Synopsis
- - Exposure to hexavalent chromium [Cr (VI)] can lead to DNA damage and increase cancer risk, while folate deficiency affects DNA stability and methylation.
- - A study of 115 chromate workers found higher chromium levels in their blood and lower serum folate compared to 60 unexposed local residents.
- - The reduced folate levels in workers were linked to increased DNA damage, suggesting that folate supplements could help stabilize genetic material and lower cancer risk for those exposed to chromium.