RGD-modified endostatin fragments showed an antitumor effect through antiangiogenesis.

EDSM, an endostatin-derived synthetic polypeptide, contains the amino acids 6-48 of endostatin from its N-terminus, which could inhibit human umbilical vein endothelial cell (HUVEC) migration and tumor growth. To increase the targeted delivery of EDSM to tumors and further enhance its antiangiogenic activity, the RGD sequence (Arg-Gly-Asp) was introduced into EDSM and two peptides were obtained: EDSM-X with RGD on the N-terminus of EDSM and EDSM-Y with RGD on the C-terminus. Both modified peptides showed a significant antiangiogenic activity in the HUVEC migration assay, the HUVEC tube formation assay, and the murine aortic ring formation assay in vitro.

[Chemical components and their allelopathic effects of the volatiles from Larix principis-rupprechtii leaves and branches].

The chemical components of the volatiles from the leaves and branches of Larix principis-rupprechtii were analyzed by GC-MS, with their allelopathic effects on the seed germination and growth of L. principis-rupprechtii itself investigated. The results indicated that the volatiles contained 20 major components, and the main constituents were terpenes and their oxidized derivatives, in which, there were 5 monoterpenes and 12 sesquiterpenes.