Intravenous immunoglobulin treatment for patients with severe COVID-19: a retrospective multicentre study.

Objectives: Intravenous immunoglobulin (IVIG) is commonly used to treat severe COVID-19, although the clinical outcome of such treatment remains unclear. This study evaluated the effectiveness of IVIG treatment in severe COVID-19 patients.

Methods: This retrospective multicentre study evaluated 28-day mortality in severe COVID-19 patients with or without IVIG treatment.

Toxic mechanism of three azole fungicides and their mixture to green alga Chlorella pyrenoidosa.

Currently, few studies have investigated the joint toxicity mechanism of azole fungicides at different exposure times and mixed at the relevant environmental concentrations. In this study, three common azole fungicides, namely, myclobutanil (MYC), propiconazole (PRO), and tebuconazole (TCZ), were used in studying the toxic mechanisms of a single substance and its ternary mixture exposed to ambient concentrations of Chlorella pyrenoidosa. Superoxide dismutase (SOD), catalase (CAT), chlorophyll a (Chla), and total protein (TP), were used as physiological indexes.

First-trimester blood concentrations of drinking water trihalomethanes and neonatal neurobehavioral development in a Chinese birth cohort.

Toxicological evidence indicates that exposure to drinking water trihalomethanes (THMs) can impair neural development. However, no epidemiologic study to date has evaluated the relation of trihalomethanes exposure with neonatal neurobehavioral development. Here we aimed to evaluate if prenatal exposure to THMs during early pregnancy is associated with neonatal neurobehavioral development in 451 Chinese mother-child pairs.

The role of leptin in striped hamsters subjected to food restriction and refeeding.

Food restriction (FR) and refeeding (Re) have been suggested to impair body mass regulation and thereby making it easier to regain the lost weight and develop over-weight when FR ends. However, it is unclear if this is the case in small mammals showing seasonal forging behaviors. In the present study, energy budget, body fat and serum leptin level were measured in striped hamsters that were exposed to FR-Re.

Decreased circulating leptin and increased neuropeptide Y gene expression are implicated in food deprivation-induced hyperactivity in striped hamsters, Cricetulus barabensis.

Physiological and behavioral adjustments of small mammals are important strategies in response to variations in food availability. Although numerous of studies have been carried out in rodents, behavioral patterns in response to food deprivation and re-feeding (FD-RF) are still inconsistent. Here we examined effects of a 24h FD followed by RF on general activity, serum leptin concentrations and gene expression of orexigenic and anorexigenic hypothalamic neuropeptides in striped hamsters (Cricetulus barabensis) with/without leptin supplements.

The resolution estimation of wedge and strip anodes.

A new resolution estimation method for wedge and strip anode based on the single photon imaging configuration is provided. The limiting resolution estimation equation is deduced theoretically according to the threshold principle. The relation between the charge cloud and the covered electrodes is discussed, and the equivalent diameter number is calculated.

Repressor of GATA-3 can negatively regulate the expression of T cell cytokines through modulation on inducible costimulator.

Background: The transcription factor, repressor of GATA-3 (ROG), can simultaneously suppress the expression of T helper cells (Th1 and Th2) cytokines. Since the suppression of Th2 cytokines by GATA-3 is well understood, it is postulated that there are other molecular targets of ROG that can suppress the expression of the Th1 cytokines. We hypothesized that ROG might suppress the stimulators of T lymphocyte cytokines such as CD3, CD28, and inducible costimulator (ICOS), or indirectly enhance the expression of cytokine suppressors such as T lymphocyte-associated antigen-4 (CTLA-4) and CD45.

[Effects of drought stress and nitrogen fertilization rate on the accumulation of osmolytes in Jatropha curcas seedlings].

A pot experiment with controlled water supply was conducted to study the effects of different drought stress degree (80% FC, 60% FC, 40% FC, and 20% FC) and nitrogen fertilization rate (0 g x pot(-1), 1.2 g x pot(-1), 3.6 g x pot(-1), and 6.

Continuous measurement of the arrival times of x-ray photon sequence.

In order to record x-ray pulse profile for x-ray pulsar-based navigation and timing, this paper presents a continuous, high-precision method for measuring arrival times of photon sequence with a common starting point. In this method, a high stability atomic clock is counted to measure the coarse time of arrival photon. A high resolution time-to-digital converter is used to measure the fine time of arrival photon.

Ghosting phenomena in single photon counting imagers with Vernier anode.

We provide the ghosting theory of two-dimensional Vernier anode based imagers. The single photon counting detection system based on Vernier anode is constructed. The ghosting, which occurs during the decoding of two-dimensional Vernier anode, and its possible solutions are described in detail.

[Effect of drought on photosynthetic characteristics and growth of Jatropha curcas seedlings under different nitrogen levels].

A pot experiment with controlled water supply was conducted to study the effects of drought stress (continuous drought for 0 d, 5 d, 10 d, ...

The estimation of charge footprint size of ultraviolet photon counting imaging detector with induction readout.

The structure and work principle of an ultraviolet photon counting imaging detector based on wedge and strip anode with induction readout mode are introduced. Two methods of estimating the charge footprint size are presented. One way is theoretical calculation and simulation.