Identification of macrophage driver genes in fibrosis caused by different heart diseases based on omics integration.

Background: Myocardial fibrosis, a hallmark of heart disease, is closely associated with macrophages, yet the genetic pathophysiology remains incompletely understood. In this study, we utilized integrated single-cell transcriptomics and bulk RNA-seq analysis to investigate the relationship between macrophages and myocardial fibrosis across omics integration.

Methods: We examined and curated existing single-cell data from dilated cardiomyopathy (DCM), ischemic cardiomyopathy (ICM), myocardial infarction (MI), and heart failure (HF), and analyzed the integrated data using cell communication, transcription factor identification, high dimensional weighted gene co-expression network analysis (hdWGCNA), and functional enrichment to elucidate the drivers of macrophage polarization and the macrophage-to-myofibroblast transition (MMT).

Construction of Coordination Spaces with Narrow Pore Windows in Co-Based Metal-Organic Frameworks toward CO/N Separation.

Carbon emission reduction is an important measure to mitigate the greenhouse effect, which has become a hotspot in global climate change research. To contribute to this, here, we fabricated two Co-based metal-organic frameworks (Co-MOFs), namely, {[Co(NTB)(bib)]·(DMA)·(HO)} (DZU-211) and {[Co(NTB)(bmip)]·(DMA)} (DZU-212) (HNTB = 4,4',4″-nitrilotribenzoic acid, bib = 1,4-bis(imidazol-1-yl)-butane, bmip = 1,3-bis(2-methyl-1-imidazol-1-yl)propane) to realize efficient CO/N separation by dividing coordination spaces into suitable pores with narrow windows. DZU-211 reveals a 3D open porous framework, while DZU-212 exhibits a 3D double-fold interpenetrated structure.

Pore Environment Optimization of Microporous Metal-Organic Frameworks with Huddled Pyrazine Pillars for CH/CO Separation.

Metal-organic frameworks (MOFs) have been proven promising in addressing many critical issues related to gas separation and purification. However, it remains a great challenge to optimize the pore environment of MOFs for purification of specific gas mixtures. Herein, we report the rational construction of three isostructural microporous MOFs with the 4,4',4"-tricarboxyltriphenylamine (HTCA) ligand, unusual hexaprismane NiO cluster, and functionalized pyrazine pillars [PYZ-x, x = -H (DZU-10), -NH (DZU-11), and -OH (DZU-12)], where the building blocks of NiO clusters and huddled pyrazine pillars are reported in porous MOFs for the first time.

Exploring the molecular mechanism of hepatitis virus inducing hepatocellular carcinoma by microarray data and immune infiltrates analysis.

The number of new cases of hepatocellular carcinoma (HCC) worldwide reached 910,000, ranking the sixth, 80% HCC is associated with viruses, so exploring the molecular mechanism of viral carcinogenicity is imperative. The study showed that both HBV and HCV associated HCC and non-viral HCC have the same molecular phenotype (low gene expression and inhibition of immune pathways), but in the tumor immune micro-environment, there is excessive M2-type macrophage polarization in virus-associated hepatocellular carcinoma. To address this phenomenon, the data sets were analyzed and identified five hub genes (POLR2A, POLR2B, RPL5, RPS6, RPL23A) involved in viral gene expression and associated with PI3K-Akt-mTOR pathway activation by six algorithms.

The Effect of Psoralen on Glioma Based on Network Pharmacology and Potential Target Research.

Glioma is an aggressive tumor, currently there is no satisfactory management available. Psoralen, as a natural product, has been found to have an effect of treating cancer in recent years, but its effect on glioma has not been explored. In this study, we investigated the in vitro inhibition effect and potential targets of psoralen on glioma through network pharmacology and in glioma treatment experiments.

Trace removal of benzene vapour using double-walled metal-dipyrazolate frameworks.

In principle, porous physisorbents are attractive candidates for the removal of volatile organic compounds such as benzene by virtue of their low energy for the capture and release of this pollutant. Unfortunately, many physisorbents exhibit weak sorbate-sorbent interactions, resulting in poor selectivity and low uptake when volatile organic compounds are present at trace concentrations. Herein, we report that a family of double-walled metal-dipyrazolate frameworks, BUT-53 to BUT-58, exhibit benzene uptakes at 298 K of 2.

Interpenetrated metal-organic frameworks with enhanced photoluminescence for selective recognition of -xylene from xylene isomers.

Two novel luminescent metal-organic frameworks (MOFs), [Zn(TCA)(BPB)] (DZU-101, where HTCA = 4,4',4''-tricarboxyltriphenylamine and BPB = 1,4-bis(pyrid-4-yl)benzene) and [Zn(TCA)(BPB)DMA] (DZU-102), based on the same ligands and metal ions were synthesized by regulating the amount of water in the solvothermal reaction system. Structural analyses show that the two MOFs have pillar-layered frameworks with Zn clusters connected by the TCA and BPB ligands. Interestingly, DZU-102 possessed a two-fold interpenetrated framework distinct from the individual network of DZU-101.

Pillar-Layered Metal-Organic Frameworks Based on a Hexaprismane [Co6(μ3-OH)6] Cluster: Structural Modulation and Catalytic Performance in Aerobic Oxidation Reaction.

Embedding a functional metal-oxo cluster within the matrix of metal-organic frameworks (MOFs) is a feasible approach for the development of advanced porous materials. Herein, three isoreticular pillar-layered MOFs (Co-MOF-1-3) based on a unique [Co(μ-OH)] cluster were designed, synthesized, and structurally characterized. For these Co-MOFs, tuning of the framework backbone was facilitated due to the existence of second ligands, which results in adjustable apertures (8.

A Green-Emission Metal-Organic Framework-Based Nanoprobe for Imaging Dual Tumor Biomarkers in Living Cells.

The modular nature of metal-organic frameworks (MOFs) permits their tunable structure and function for target application, such as in biomedicine. Herein, a green-emission Zr(IV)-MOF (BUT-88) was constructed from a customized luminescent carbazolyl ligand. BUT-88 represents the first bcu-type MOF with both organic linker and metal node in eight connections and shows medium-sized pores, rich accessible linking sites, and good water stability and biocompatibility.

Combining unsaturated metal sites and narrow pores within a Co(ii)-based MOF towards CO separation and transformation.

A Co(ii)-based MOF, {[Co(L)(bpb)(DMA)(HO)]·Solvents} (RH-1), with a unique interpenetrated framework has been solvothermally prepared. Because of its unsaturated metal sites and narrow pores inside the framework, RH-1 demonstrated excellent selective CO adsorption over N and CH and good performance in catalytic CO conversion to cyclic carbonates under mild conditions.

Two microporous Co-MOFs with dual active sites for highly selective adsorption of CO/CH and CO/N.

Simultaneously involving abundant [NH2(CH3)2]+ cations and uncoordinated carboxylate oxygen atoms as dual active sites, two microporous CoII-MOFs (LCU-105 and LCU-106, LCU = Liaocheng University) both exhibit highly selective adsorption of CO2/CH4 and CO2/N2. GCMC theoretical simulations provide good verification of the experimental results.

Ligand Rigidification for Enhancing the Stability of Metal-Organic Frameworks.

Metal-organic frameworks (MOFs) have been developing at an unexpected rate over the last two decades. However, the unsatisfactory chemical stability of most MOFs hinders some of the fundamental studies in this field and the implementation of these materials for practical applications. The stability in a MOF framework is mostly believed to rely upon the robustness of the M-L (M = metal ion, L = ligand) coordination bonds.

Nanocage-Based Porous Metal-Organic Frameworks Constructed from Icosahedrons and Tetrahedrons for Selective Gas Adsorption.

Two isostructural nanocage-based porous Ni/Co(II)-MOFs have been hydrothermally synthesized, which were interestingly composed of icosahedron and tetrahedron cages with a new (3,8)-connected 3D topology. Moreover, the stable Ni-MOF exhibits good selective CO/CH and CO/N adsorption owing to its exposed nitrogen active sites.

Constructing new metal-organic frameworks with complicated ligands from "One-Pot" reactions.

Metal-organic frameworks (MOFs) have emerged as one of the most fascinating libraries of porous materials. In spite of their myriad merits, practical application of most MOFs is restricted due to their high preparation cost because of the complicated organic ligands involved. To address this limitation, we propose to use simple and cheap organic precursors to synthesize MOFs with complicated ligands "one-pot" reactions of these precursors along with the formation of new MOFs.

Structure modulation from unstable to stable MOFs by regulating secondary N-donor ligands.

Four new Zn(ii)/Cd(ii)-based metal-organic frameworks (MOFs), namely {[Cd(tmdb)(bib)0.5]·solvents}n (YZ-7, YZ stands for the initials of the author Yong-Zheng Zhang), {[Cd(tmdb)(bmib)0.5]·solvents}n (YZ-8), {[Zn2(tmdb)2(bmib)]·solvents}n (YZ-9) and {[Zn2(tmdb)2(bmip)2]·solvents}n (YZ-10) have been solvothermally synthesized by using a semi-rigid ligand, 4,4'-(H-1,2,4-triazol-1-yl)methylene-dibenzoic acid (H2tmdb), and a series of secondary bis-imidazole ligands (bib = 1,4-bis(1H-imidazol-1-yl)benzene, bmib = 1,4-bis(2-methyl-1H-imidazol-1-yl)benzene, and bmip = 1,3-bis(2-methyl-1H-imidazol-1-yl)propane).

Tuning Water Sorption in Highly Stable Zr(IV)-Metal-Organic Frameworks through Local Functionalization of Metal Clusters.

Water adsorption of metal-organic frameworks (MOFs) is attracting intense interest because of their potential applications in atmospheric water harvesting, dehumidification, and adsorption-based heating and cooling. In this work, through using a hexacarboxylate ligand, four new isostructural Zr(IV)-MOFs (BUT-46F, -46A, -46W, and -46B) with rare low-symmetric 9-connected Zr clusters were synthesized and structurally characterized. These MOFs are highly stable in water, HCl aqueous solution (pH = 1), and NaOH aqueous solution (pH = 10) at room temperature, as well as in boiling water.

Zr(IV)-Based Metal-Organic Framework with T-Shaped Ligand: Unique Structure, High Stability, Selective Detection, and Rapid Adsorption of CrO in Water.

Dichromate is known for severe health impairments to organisms. New and valid strategies have been developed to rapidly detect and efficiently remove this pollutant. Constructing stable luminescent metal-organic frameworks (MOFs) for dichromate recognition and removal from aqueous solution could provide a feasible resolution to this problem.

Abnormal room temperature phosphorescence of purely organic boron-containing compounds: the relationship between the emissive behaviorand the molecular packing, and the potential related applications.

Purely organic materials with the characteristic of room-temperature phosphorescence (RTP) under ambient conditions demonstrate potential benefits in advanced optoelectronic applications. Exploration of versatile and efficient RTP compounds with low prices is full of challenges due to the slow intersystem crossing process and ultrafast deactivation of the active excited states of organic compounds. Here, a series of boron-containing phosphors were found to present RTP with long-lived lifetimes.

Functionalized Base-Stable Metal-Organic Frameworks for Selective CO Adsorption and Proton Conduction.

Metal-organic frameworks (MOFs) have shown great potential for application in various fields, including CO capture and proton conduction. For promoting their practical applications, both optimization of a given property and enhancement of chemical stability are crucial. In this work, three base-stable isostructural MOFs, [Ni (OH) (H O) (BDP-X) ] (Ni-BDP-X; H BDP=1,4-bis(4-pyrazolyl)benzene, X=CHO, CN, COOH) with different functional groups, are designed, synthesized, and used in CO capture and proton conduction experiments.

Water-Stable In(III)-Based Metal-Organic Frameworks with Rod-Shaped Secondary Building Units: Single-Crystal to Single-Crystal Transformation and Selective Sorption of CH over CO and CH.

Three new water-stable In(III)-based metal-organic frameworks, namely, [In(TTTA)(OH)(HO)]·(DMA) (BUT-70, DMA = N,N-dimethylacetamide), [In(TTTA)(CHO)] (BUT-70A), and [In(TTTA)(OH)] (BUT-70B), with rod-shaped secondary building units (SBUs) and an new acrylate-based ligand, (2E,2'E,2″E)-3,3',3″-(2,4,6-trimethylbenzene-1,3,5-triyl)-triacrylate (TTTA) were obtained and structurally characterized. BUT-70A and -70B were generated in a single-crystal to single-crystal transformation fashion from BUT-70 through guest exchange followed by their removal. The solvents used for guest exchange were methanol and dichloromethane, respectively.

A Base-Resistant Zn -Based Metal-Organic Framework: Synthesis, Structure, Postsynthetic Modification, and Gas Adsorption.

A Zn -based metal-organic framework (MOF), [Zn (bdp-CHO) ]⋅(DMF)(CH CN)(H O) (BUT-31) is reported that was synthesized by the reaction between a newly designed aldehyde-tagged polypyrazole ligand 2,5-di(1H-pyrazol-4-yl)benzaldehyde (H bdp-CHO) and a zinc salt. BUT-31 has a unique pillared layered framework structure with 3D intersecting channels approximately 3.4-5.

A hydrothermally stable Zn(ii)-based metal-organic framework: structural modulation and gas adsorption.

By the solvothermal reaction of a triangular ligand, 2,4,6-tris-(4-carboxyphenoxy)-1,3,5-triazine (H3tcpt) with Zn(NO3)2·6H2O in N,N'-dimethylacetamide/acetonitrile/H2O (v/v/v = 1 : 1 : 1) mixed solvents, a two-fold, interpenetrated, three-dimensional (3D), porous metal-organic framework, [Zn2(tcpt)OH]·solvents (1·solvents), with a rare, paddlewheel secondary building unit (SBU), Zn2(COO)3, was synthesized and characterized. It was found that a single 3D structure of 1 forms when two-dimensional layers, which are constructed by tcpt(3-) bonding with the paddlewheel SBUs, are linked by -OH groups along the axial sites of the SBUs. Compared with the reported Zn(ii)-based partners with this ligand, synthesis conditions, particularly the solvents used, clearly played a key role in the formation of different SBUs, thereby resulting in distinct MOFs with the same ligand.

[Role of water-water circulation in excessive light energy dissipation of ginger leaves].

To investigate the photo-protection of water-water circulation in ginger leaves, the effects of different treatments such as natural light + water control (T1), shading 50% + water control (T2), natural light + 10 mmol x L(-1) IA (T3), shading 50% + 10 mmol x L(-1) IA (T4) on leaf chlorophyll fluorescence parameters, Mehler reaction and the activities of SOD, APX of potted ginger were studied. The results showed that the Pn and Fv/Fm of ginger leaves in T3 and T4 reduced constantly, but that of T1 and T2 had no significant change during treatment. For example, at the ninth day after treatment, the Pn of T3 and T4 decreased by 64% and 33.