Publications by authors named "Yong-Zhen Wang"
Article Synopsis
- Malignant ventricular arrhythmias (VA) following a myocardial infarction (MI) are linked to changes in heart electrical properties, and BRG1 plays a key role in this remodeling process.* -
- The study involved creating a mouse model of MI and using various techniques, including ECG monitoring and optical voltage mapping, to analyze the effects of BRG1 on ion channel behavior and cardiac function.* -
- Findings reveal that increased BRG1 expression after MI worsens the heart's electrical stability, while knocking down BRG1 improves conduction speed and heart rhythm, suggesting its potential as a therapeutic target for arrhythmias post-MI.*
Article Synopsis
- PFI-3 is a newly developed small-molecule inhibitor that selectively targets BRGs, showing potential as a therapeutic agent, though its effects on vascular function needed investigation.
- In experiments using a microvascular tension measurement device and fluorescence techniques, PFI-3 was found to cause relaxation in rat mesenteric arteries in response to various constrictors, without being influenced by certain blockers.
- The results indicated that PFI-3 reduces calcium influx and the activity of L-type voltage-dependent calcium channels in arterial smooth muscle cells, contributing to its vasodilatory effects.
[Expression of follicular helper T cells in peripheral blood of patients with hepatic echinococcosis].
Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi
December 2018
Objective: To detect the expression of follicuLar helper T cells (Tfh) and interleukin-21 (IL-21) in the peripheral blood of patients with hepatic echinococcosis and healthy controls, so as to explore the associations of Tfh and IL-21 expression with the progression of hepatic echinococcosis.
Methods: Fifty cases of hepatic echinococcosis and healthy controls were collected from Qinghai Provincial People's Hospital, respectively. Flow cytometry was used to detect the expression of Tfh cells in the peripheral blood of hepatic echinococcosis patients and healthy controls, and enzyme-linked immunosorbent assay (ELISA) was used to detect serum IL-21 expression in hepatic echinococcosis patients and healthy controls.
As is known, hepatic stellate cells (HSCs) activation contributes to liver cirrhosis. This study aims to find out the acting mechanisms of miR-454 inhibiting the activation and proliferation of hepatic stellate cells. The expression of Col1A1, α-smooth muscle actin (α-SMA) and Wnt10a were determined by western blot, and the miR-454 level was determined by quantitative real-time PCR in this study.
View Article and Find Full Text PDFAim: Recently, many reports showed that the pretransplant neutrophil-lymphocyte ratio (NLR) may be correlated with the prognosis of patients undergoing liver transplantation (LT) for hepatocellular cancer (HCC). However, their results still remained controversial. Thus we performed a meta-analysis of 13 studies to estimate the prognostic value of pretransplant NLR.
View Article and Find Full Text PDFObjective: To make an useful identification method for the molecule of DNA on 3 herbs of Artemisia genus and compare the differences of the genes of Korean and Chinese species of Artemisia.
Methods: Sequence of 3 herbs (Artemisia sacrorum Ledeb., Artemisia iwayomogi Kitam.