Publications by authors named "Yong-Zhen Tan"
Article Synopsis
- Myocardial ischemia-reperfusion (I/R) injury contributes to significant cardiovascular issues, with ferroptosis being a key factor in this damage; the study focuses on Ilexgenin A's effects on this process.
- In vivo experiments used a mouse model to assess Ilexgenin A's protective abilities against cardiac dysfunction, while in vitro tests on neonatal rat cardiomyocytes explored its pharmacological mechanisms.
- Results indicated that Ilexgenin A effectively reduces myocardial ferroptosis and mitochondrial damage through the SIRT1 pathway, and knocking down SIRT1 diminishes its protective benefits.
Background: Sepsis-induced cardiac dysfunction (SICD) is a serious complication of sepsis that is associated with increased mortality. Ferroptosis has been reported in the SICD. TaoHe ChengQi decoction (THCQD), a classical traditional Chinese medicinal formula, has multiple beneficial pharmacological effects.
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- Myocardial fibrosis is a growing health issue linked to heart attacks (myocardial infarctions), prompting the need for effective treatments.
- This study explores the effects of a natural compound, ethyl ferulate (EF), on the TGF-receptor 1 (TGFBR1) signaling pathway in the context of myocardial fibrosis after a heart attack.
- Results showed that EF reduced fibrosis and improved heart function by inhibiting TGFBR1 signaling, both in live mice and in cell cultures, indicating its potential as a therapeutic agent for heart conditions.
Local anesthetics are frequently used by dentists to relieve localized discomfort of the patient and improve treatment conditions. The risk of paresthesia after local anesthesia is frequently encountered in dental clinics. The neurotoxicity of local anesthetics is a disregarded factor in paresthesia.
View Article and Find Full Text PDFMyocardial infarction (MI) is the leading cause of death worldwide, and oxidative stress is part of the process that causes MI. Calycosin, a naturally occurring substance with cardioprotective properties, is one of the major active constituents in Radix Astragali. In this study, effect of Calycosin was investigated in vivo and in vitro to determine whether it could alleviate oxidative stress and oxidative stress-induced cardiac apoptosis in neonatal cardiomyocytes (NCMs) via activation of aldehyde dehydrogenase 2 (ALDH2).
View Article and Find Full Text PDFObjective: To observe the influence of Qingxiang San (QS) on substance P (SP), somatostatin (SS) in rats model of spleen and stomach wet heat syndrome.
Methods: 24 rats were divided into 3 groups (each group 8 rats) randomly: the normal control group (NCG), wet heat group (WHG), QS group (QSG). We set up the spleen and stomach wet heat syndrome of rats model by the composite factors such as greasy and sweet food, wet and hot environment, pathogen and so on.